The Peter Attia Drive

Dr. Iñigo San Millán, an expert in exercise and metabolism from the University of Colorado, dives deep into the critical role of mitochondria in metabolic health. He explains how different energy systems and the often-misunderstood lactate fuel our workouts. Iñigo emphasizes the significance of zone 2 training for both health diagnostics and treatment of metabolic dysfunction. Discussions on the physiological differences between elite athletes and those with metabolic issues offer fascinating insights into the future of exercise science and nutrition.

Scott Harrison, Founder of charity: water, shares his journey from nightclub promoter to social entrepreneur, championing global clean water access. He discusses the innovative strategies his nonprofit employs, focusing on transparent donations and positive branding that fosters hope rather than guilt. Harrison also tackles the stigma surrounding nonprofits, emphasizing the need for effective messaging that inspires engagement. Finally, he highlights the importance of community-led projects to ensure sustainable access to clean drinking water.

In this engaging AMA session, the discussion dives into testosterone supplementation and its potential impacts on longevity. Find out how low testosterone is diagnosed and what risks come with replacement therapy. The conversation also covers hypothyroidism treatment and the balance of building muscle while fasting. Can you simultaneously lose fat and gain muscle? Explore the intricacies of these health topics and learn strategies for effective muscle preservation during time-restricted feeding.

The podcast dives into the challenges of overhauling a food system dominated by just ten companies controlling 90% of calories. It highlights the unhealthy additives common in processed foods and suggests public education and legal actions as potential reform strategies. The discussion also uncovers how food subsidies skew pricing, making junk food cheap, while healthier options remain expensive. Lastly, it critiques food marketing practices, drawing parallels with smoking regulations, and underscores the need for stricter controls to protect public health.

Bill Harris, an internationally recognized omega-3 expert and professor, shares his extensive knowledge on fatty acids. He dives into the health benefits of omega-3s, particularly EPA and DHA, emphasizing their significance for heart health. Harris discusses the history of dietary fats, clarifying misconceptions surrounding omega-6 and omega-3 ratios. He highlights the differences between prescribed fish oil drugs and OTC supplements, while explaining the impact of various oils on cholesterol. Insights on the Inuit diet bring added context to omega-3 intake and its effects.

Dr. Robert Lustig, a renowned expert on fructose and metabolic health, shares invaluable insights tailored for parents and kids. He highlights the hidden sugars lurking in everyday foods and their impact on children's health. Discussing dietary challenges, he emphasizes the importance of whole, unprocessed foods over processed alternatives. Lustig also introduces innovative communal breakfast meetings aimed at educating families about healthier food choices, while tackling the obstacles of time and cost in adopting better eating habits.

Mark Messier, a six-time Stanley Cup champion with over 25 years in the NHL, shares his journey from hockey great to leader off the ice. He discusses the importance of humble leadership and teamwork, how he learned from legends like Wayne Gretzky, and the pressure of performing in high-stakes situations. Messier reflects on pivotal moments, his transition to family life, and the challenges of youth sports today. His insights on resilience and personal growth provide a fascinating look at what it takes to thrive under pressure.

Dive into the intriguing concept of how strong intuition can outweigh unreliable medical tests. Historical context and prior knowledge emerge as vital tools for effective decision-making in medicine. The discussion emphasizes the profound impact of intuition on patient care, blending personal stories with professional insights. Preparing for the unexpected becomes crucial as listeners are reminded of the lesser-known yet powerful aspects of medical practice.

Dr. Debra Kimless, an anesthesiologist and Chief Medical Officer at Pure Green Cannabis, and Steve Goldner, the company's Founder and CEO, dive deep into the science of cannabis. They clarify the differences between THC and CBD, discussing their unique interactions with the body and brain. The duo addresses the safety concerns surrounding vaping and the importance of regulation, aiming to shift public perception of cannabis. Moreover, they share insights on the evolving legal landscape for medicinal cannabis and its potential benefits for chronic conditions.

Delve into the fascinating world of rapamycin and its potential in cancer treatment. Discover how this compound interacts with immune function and affects cancer progression differently based on dosage and gender. Learn about the exciting possibilities of combining rapamycin with immune therapies to boost CD8 responses. The discussion also highlights the rising incidence of cancer with age and the decline of immune function, offering hope for interventions that could enhance our defenses against cancer.