JAMA Network

In this insightful discussion, David Hui, a leading authority in palliative care from the University of Texas MD Anderson Cancer Center, and Eduardo Bruera, a renowned expert in delirium management, delve into their groundbreaking study on agitated delirium in cancer patients. They discuss innovative sedation strategies tailored for terminal patients, the emotional toll of delirium on families, and the need for personalized care. Their findings emphasize the importance of teamwork in palliative care and call for future research to enhance patient outcomes and support.

In this insightful discussion, Roxana Mehran, a leading cardiologist and vice president of the American College of Cardiology, shares her expertise on the importance of clinical trial representativeness. She discusses the challenges of recruiting diverse populations and suggests actionable strategies for enhancing inclusivity in trials. Mehran emphasizes how community engagement and demographic considerations can improve outcomes and trust in clinical research. The conversation highlights the growing role of industry in ensuring that clinical trials reflect the populations they aim to serve.

Jennifer Rose-Nussbaumer, an associate professor of ophthalmology at Stanford University, dives into groundbreaking research on treating bacterial keratitis. She discusses the pivotal SCUT II trial, revealing the benefits of adjunctive corticosteroids and corneal cross-linking. Controversies surrounding diagnosis and treatment timing are explored, along with the importance of prioritizing clinical outcomes beyond just visual acuity. Rose-Nussbaumer emphasizes the ongoing challenges and the need for further trials to refine effective treatment strategies.

Interview with Eric L. Simpson, MD, MCR, author of Emollients to Prevent Pediatric Eczema: A Randomized Clinical Trial. Hosted by Adewole S. Adamson, MD. Related Content: Emollients to Prevent Pediatric Eczema Emollients to Prevent Atopic Dermatitis—Is New Evidence a Game Changer?

Dennis J. Rivet II, a neurosurgery professor at Virginia Commonwealth University, discusses the promising role of GLP-1 receptor agonists in managing idiopathic intracranial hypertension. He outlines how obesity influences this condition and examines various treatment strategies, including medication and surgery. Rivet also sheds light on the neurological benefits of GLP-1 agonists that extend beyond weight management. The conversation emphasizes the need for further research and collaboration in this evolving field.

Interview with Alphonsus Matovu, MD and Jenny Löfgren, MD, PhD authors of Open Anterior Mesh Repair vs Modified Open Anterior Mesh Repair for Groin Hernia in Women: A Randomized Clinical Trial. Hosted byAmalia Cochran, MD Related Content: Open Anterior Mesh Repair vs Modified Open Anterior Mesh Repair for Groin Hernia in Women Repairing Groin Hernias in Women—Another Reason to Democratize Laparoscopy

In this enlightening discussion, Dennis J. Rivet II, an esteemed neurosurgeon and researcher from Virginia Commonwealth University, dives into the intriguing world of idiopathic intracranial hypertension (IIH) and the promising role of GLP-1 receptor agonists in its treatment. He highlights the complexities surrounding IIH, including its connection to obesity and the innovative use of GLP-1s in managing symptoms while potentially reducing the need for surgeries. Rivet also emphasizes the necessity of considering BMI and metabolic health for comprehensive patient care.

Sameer Jauhar, a researcher at Imperial College London, dives into the complexities of antidepressant discontinuation symptoms. He outlines a comprehensive review that highlights the often-overlooked withdrawal challenges, like electric shocks and dizziness. The conversation delves into the history of research on these symptoms and critiques previous studies for their limitations. Jauhar emphasizes the crucial need for clinicians to differentiate between withdrawal and relapse, offering vital insights to improve patient care in mental health.

Interview with Adrian D. Haimovich, MD, PhD, author of National Trends in Prolonged Emergency Department Length of Stay Among Older Adults: 2017-2024 and Maura Kennedy, MD, MPH author of Addressing the Hospital Boarding Crisis in the US—Time to Act: Addressing the Hospital Boarding Crisis in the US. Hosted by Eve Rittenberg, MD. Related Content: Addressing the Hospital Boarding Crisis in the US—Time to Act Prolonged Emergency Department Stays for Older US Adults

Interview with Aaron Alexander-Bloch, MD, PhD, and Kevin Y. Sun, BA, authors of Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence. Hosted by John Torous, MD. Related Content: Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence