JAMA Network

Interview with Ann Brunson, MS, and Theresa H. M. Keegan, PhD, MS, authors of Metastatic Recurrence Among Adolescents and Young Adults With Cancer. Hosted by Vivek Subbiah, MD. Related Content: Metastatic Recurrence Among Adolescents and Young Adults With Cancer Metastatic Recurrence in Adolescent and Young Adult Cancer—Key Drivers of Early Mortality

Join John P. Ney, MD, MPH, an expert in neurology and health economics, as he explores the staggering impact of nervous system disorders in the U.S. He reveals that 180 million Americans are affected, with tension headaches and stroke leading the charge. Dive into the Global Burden of Disease Study and discover the alarming 16.6 million disability-adjusted life years lost. Ney advocates for increased research funding and policy reforms to address these challenges, urging a shift in focus from individual to population health.

Interview with Kristine A. Smith, MD, author of Evaluation of Practice Patterns for 6-Sinus Balloon Sinus Dilation; Jay F. Piccirillo, MD, author of Balloon Sinus Dilation Use; and Donald C. Lanza, MD, MS, author of Balloon Sinus Dilation—To Inflate or Not to Inflate. Hosted by Paul C. Bryson, MD, MBA. Related Content: Evaluation of Practice Patterns for 6-Sinus Balloon Sinus Dilation Balloon Sinus Dilation—To Inflate or Not to Inflate Balloon Sinus Dilation Use

Interview with Darren Shu Jeng Ting, MBChB, PhD, author of Performance of Foundation Models vs Physicians in Textual and Multimodal Ophthalmological Questions. Hosted by Neil Bressler, MD. Related Content: Performance of Foundation Models vs Physicians in Textual and Multimodal Ophthalmological Questions Mastering Ophthalmology in the Digital Age

Interview with Elizabeth J. Phillips, MD, author of Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Hosted by Adewole S. Adamson, MD. Related Content: Recovering From Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Interview with Giselle Corbie, MD, MSc, Associate Editor of JAMA Internal Medicine, and Lynda H. Powell, PhD, author of Lifestyle Intervention for Sustained Remission of Metabolic Syndrome: A Randomized Clinical Trial. Hosted by Eve Rittenberg, MD. Related Content: Lifestyle Intervention for Sustained Remission of Metabolic Syndrome

Edward L. Giovannucci, a seasoned nutritional epidemiologist from Harvard, and Yiwen Zhang, an emerging researcher in epidemiology and nutrition, delve into the critical relationship between physical activity and digestive system cancers. They discuss surprising findings, highlighting that consistent moderate activity may be more beneficial than intense workouts. The pair also emphasize practical advice for sustainable routines, like daily walking, as pivotal for long-term health. Their insights point to the importance of continuous activity over mere intensity in preventing cancer.

Noemi Lois, a Professor of Ophthalmology at Queen's University Belfast, dives into her groundbreaking study on retinal sensitivity and perfusion in diabetic retinopathy. She discusses how retinal sensitivity is mapped using advanced perimetry techniques. Lois highlights the importance of focusing on functional outcomes and the correlation between ischemic and perfused areas. Over time, sensitivity in non-perfused zones showed modest declines, while some perfused areas retained normal sensitivity, raising hope for early interventions.

Declan M. McLoughlin, an MD and PhD psychiatrist from Trinity College Dublin, shares insights from the KARMA-Dep2 trial on ketamine's role in treating depression. He discusses the differences between esketamine nasal spray and IV ketamine, diving into how sub-anesthetic doses can cause dissociation. The conversation explores the challenges of blinding in trials and the study’s design involving 66 participants. McLoughlin also reveals the mixed outcomes regarding ketamine's antidepressant effects compared to ECT, emphasizing the need for cautious expectations.

Interview with Katharine Yao, MD, MS, and Lorraine Tafra, MD, authors of American Society of Breast Surgeons and Society of Breast Imaging 2025 Guidelines for the Management of Benign Breast Fibroepithelial Lesions. Hosted by Jamie Coleman, MD. Related Content: American Society of Breast Surgeons and Society of Breast Imaging 2025 Guidelines for the Management of Benign Breast Fibroepithelial Lesions