Talking Precision Medicine

Genialis
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Apr 2, 2019 • 29min

Building trust in rare disease with Julie Walters | Talking Precision Medicine #09

In Talking Precision Medicine podcast we sit down with experts on the application of AI and big data analytics in the drug discovery space. Our guests are innovators, business decision makers and thought leaders at the intersection of data and therapeutics. We discuss the promise, practice, challenges, and myths of AI in precision medicine. This show is brought to you by Genialis, and Rafael, our CEO, is your host.  Genialis is focused on data integration and predictive modeling of disease biology to help accelerate the discovery and de-risk the development of novel therapeutics.  Today we speak with Julie Walters. Julie is the founder of Raremark, an information hub about rare disease for patients and their families. She has a degree in molecular genetics and a background in popular journalism… and is an entrepreneur by nature. In fact, she was a Female Entrepreneur of the Year at the UK’s 2017 Enterprise Awards.  Julie believes in harnessing the power of families affected by a rare disease, and our discussion covers many of the ways Raremark aims to do just that. 
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Mar 5, 2019 • 37min

Standing up the Alliance for AI in Healthcare with Annastasiah Mhaka | Talking Precision Medicine #08

In Talking Precision Medicine podcast we sit down with experts on the application of AI and big data analytics in the drug discovery space. Our guests are innovators, business decision makers and thought leaders at the intersection of data and therapeutics. We discuss the promise, practice, challenges, and myths of AI in precision medicine. This show is brought to you by Genialis, and Rafael, our CEO, is your host. Genialis is focused on data integration and predictive modeling of disease biology… to help accelerate the discovery and de-risk the development of novel therapeutics. Today’s podcast is a special episode of Talking Precision Medicine, dedicated to the Alliance for Artificial Intelligence in Healthcare. The A-A-I-H saw its official hard launch at JP Morgan this past January, with a standing-room-only panel discussion at the Biotech Showcase. Our guest today is Dr. Annastasiah Mhaka, a Senior Advisor at Adjuvant Partners and the muscle behind standing up the AAIH. The Alliance is a global organization that aims to improve patient quality of life by creating more effective, sustainable, and accessible healthcare. Through its work on education, regulatory issues, technology standards, and more, the AAIH will foster the responsible development of emerging industry segments poised to have a tremendous impact across the healthcare spectrum. At the end of our conversation with Annastasiah, we include some bonus material recorded at The Future of AI-Powered Healthcare panel discussion at JPM. Full disclosure— Genialis is a founding member of the AAIH, and its CEO, Rafael Rosengarten, is a board director.
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Feb 19, 2019 • 39min

Modeling systems from organoids to EHRs with Olivier Elemento | Talking Precision Medicine #07

In Talking Precision Medicine podcast we sit down with experts on the application of AI and big data analytics in the drug discovery space. Our guests are innovators, business decision makers and thought leaders at the intersection of data and therapeutics. We discuss the promise, practice, challenges, and myths of AI in precision medicine. This show is brought to you by Genialis, and Rafael, our CEO, is your host. Genialis is focused on data integration and predictive modeling of disease biology… to help accelerate the discovery and de-risk the development of novel therapeutics. Today we speak with Olivier Elemento. Olivier is the Director of the Englander Institute for Precision Medicine, as well as Associate Director of the Institute for Computational Biomedicine, both at Weill Cornell Medicine. He is also co-founder of OneThree Biotech. Olivier is a practitioner par excellence, in applying advanced analytics to large genomic and patient datasets.  Our conversation covered a lot of ground, including curated knowledge bases, patient consent, breakthroughs in preclinical models, and even AR/VR.
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Feb 5, 2019 • 31min

Where were you when the FDA approved CAR-T? with Patrick Hanley | Talking Precision Medicine #06

In Talking Precision Medicine podcast we sit down with experts on the application of AI and big data analytics in the drug discovery space. Our guests are innovators, business decision makers and thought leaders at the intersection of data and therapeutics. We discuss the promise, practice, challenges, and myths of AI in precision medicine. This show is brought to you by Genialis, and Rafael, our CEO, is your host. Genialis is focused on data integration and predictive modeling of disease biology… to help accelerate the discovery and de-risk the development of novel therapeutics. Today we speak with Patrick Hanley. Patrick works at the Children’s National Hospital in Washington DC, where he serves as the director of Good Manufacturing Practices for Immunotherapy. He is also a co-founder and vice president at Mana Therapeutics — a cell therapy company harnessing our immune cells to combat cancer. He is an expert in designing and manufacturing cell therapies... and was once a fierce competitor on the Houston indoor soccer circuit.  We talk about the leaps and bounds of progress in cell therapy, and the challenges—including discovery, manufacturing, and distribution—that lay ahead.
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Jan 22, 2019 • 40min

Long on evidence, strong on science with Matthew Michelson | Talking Precision Medicine #05

In Talking Precision Medicine podcast we sit down with experts on the application of AI and big data analytics in the drug discovery space. Our guests are innovators, business decision makers and thought leaders at the intersection of data and therapeutics. We discuss the promise, practice, challenges, and myths of AI in precision medicine. This show is brought to you by Genialis, and Rafael, our CEO, is your host. Genialis is focused on data integration and predictive modeling of disease biology… to help accelerate the discovery and de-risk the development of novel therapeutics. Today we speak with Matthew Michelson. Matthew is CEO of Evid Science — a technology company using AI to make access to medical evidence as simple and seamless as possible. He is an expert in machine learning and natural language processing and an enthusiastic company builder.  We talk about how Evid supports evidence-based medicine, the value of well curated information, and the importance of doing the work to validate your science.
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Jan 8, 2019 • 30min

The organic intelligence of families in need with Ethan Perlstein | Talking Precision Medicine #04

In Talking Precision Medicine podcast we sit down with experts on the application of AI and big data analytics in the drug discovery space. Our guests are innovators, business decision makers and thought leaders at the intersection of data and therapeutics. We discuss the promise, practice, challenges, and myths of AI in precision medicine. This show is brought to you by Genialis, and Rafael, our CEO, is your host. Genialis is focused on data integration and predictive modeling of disease biology… to help accelerate the discovery and de-risk the development of novel therapeutics. Today we speak with Ethan Perlstein. Ethan is CEO at Perlara — a scientific discovery public benefit corporation that works with families, advocacy groups and BioPharma companies to develop cures for rare diseases. Perlara challenges the conventional approach to drug discovery through its scientific platform for evolutionary pharmacology. We talk about Perlara’s approach to rare disease drug discovery; The power of working with families and foundations; as well as “Organic intelligence,” and what we can learn from biology. 
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Dec 19, 2018 • 33min

The data-driven storyteller with Elia Stupka | Talking Precision Medicine #03

In Talking Precision Medicine podcast we sit down with experts on the application of AI and big data analytics in the drug discovery space. Our guests are innovators, business decision makers and thought leaders at the intersection of data and therapeutics. We discuss the promise, practice, challenges, and myths of AI in precision medicine. This show is brought to you by Genialis, and Rafael, our CEO, is your host. Genialis is focused on data integration and predictive modeling of disease biology… to help accelerate the discovery and de-risk the development of novel therapeutics. Today we speak with Elia Stupka. Elia is the Chief Analytics Officer and Senior Vice President of the Life Sciences Business at Health Catalyst — a next-generation data, analytics, and decision-support company. He has deep experience leading interdisciplinary teams in academia and industry encompassing fields such as genomics, computational biology, data science, AI and NLP and is a true visionary leader with a passion for innovation in health and life sciences. At Health Catalyst Elia is leveraging company's data to advance the life sciences—from drug discovery to understanding the patient impact of specific medications. The conversation covers a lot of ground, including Elia’s take on: using data at the point of care; key challenges in making therapeutic innovation accessible to the population at large; and the importance of storytelling in work and in life. 
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Dec 12, 2018 • 31min

AI could be made illegal tomorrow with Jonny Wray | Talking Precision Medicine #02

In Talking Precision Medicine podcast we sit down with experts on the application of AI and big data analytics in the drug discovery space. Our guests are innovators, business decision makers and thought leaders at the intersection of data and therapeutics. We discuss the promise, practice, challenges and myths of AI in precision medicine. This show is brought to you by Genialis, and Rafael, our CEO, is your host. Genialis is focused on data integration and predictive modeling in precision medicine. We help accelerate the discovery and de-risk the development of novel therapeutics. From heterogeneous data and diverse information stores, we predict with confidence drug targets and biomarkers of tolerance, efficacy and outcome. Today we speak with Jonny Wray. Jonny is the Head of Discovery Informatics at e-therapeutics—a network-driven drug discovery company. He has extensive experience in applying mathematical and computational techniques to the modeling and analysis of biological systems, and is responsible for the conceptual formulation of the network-driven drug discovery approach pioneered at e-Therapeutics. We talk about everything from appreciating the complexity of biology to mechanistic modeling to discovering an entirely new chemical compound.
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Nov 28, 2018 • 33min

AI, it’s all about the drugs with Asim Siddiqui | Talking Precision Medicine #01

In Talking Precision Medicine podcast we sit down with experts on the application of AI and big data analytics in the drug discovery space. Our guests are innovators, business decision makers and thought leaders at the intersection of data and therapeutics. We discuss the promise, practice, challenges and myths of AI in precision medicine. This show is brought to you by Genialis, and Rafael, our CEO, is your host. Genialis is focused on data integration and predictive modeling in precision medicine. We help accelerate the discovery and de-risk the development of novel therapeutics. From heterogeneous data and diverse information stores, we predict with confidence drug targets and biomarkers of tolerance, efficacy and outcome. In this episode we speak with Asim Siddiqui. Asim is the CTO at NuMedii—a data driven drug discovery company. He has deep experience in computational biology, software engineering, next-generation sequencing, and cancer informatics, and is responsible for architecting and applying NuMedii’s AIDD (Artificial Intelligence for Drug Discovery) technology. We talk about leveraging public data for discovery, communicating between data scientists, bench scientists and other stakeholders, and the potential and challenges of using AI to advance drug development.

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