Mayo Clinic Talks

To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline Guest: Saad J. Kenderian, M.B., Ch.B. (@kenderian_ss) Host: Darryl S. Chutka, M.D. (@ChutkaMD) Regenerative immunotherapy is a treatment that uses the power of our own immune system to fight malignancy. It can include targeted antibodies, cancer vaccines, or tumor infecting viruses to name a few. Some immunotherapy treatments use genetic engineering to enhance our immune cell’s cancer fighting properties and can be used in combination with more traditional treatments including surgery, chemotherapy, or radiation. It’s FDA-approved as a first line treatment of multiple cancers and may also be effective in the management of malignancies that have been resistant to more traditional therapy. This podcast will address regenerative immunotherapy with Dr. Saad Kenderian, a hematologist at the Mayo Clinic. We’ll review the relationship between cancer and our immune system, how we can use our immune system to treat malignancy and which malignancies which have shown the best responses to regenerative immunotherapy.  Specific topics discussed: Relationship between cancer and our immune system How we can use our body’s immune system to fight malignancy Malignancies which can be currently be effectively treated with regenerative immunotherapy Malignancies which have had the best responses to regenerative immunotherapy Limitations in regenerative immunotherapy  Additional educational opportunities from Mayo Clinic: https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/ Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.  

Guest: Kathryn J. Ruddy, M.D. (@KathrynRuddyMD) Host: Darryl S. Chutka, M.D. (@ChutkaMD) Breast cancer in men is very uncommon, about 1/100th as common as in women. It’s expected that this year, just under 3000 men are likely to be diagnosed with it, and just over 500 men will die from breast cancer. Because it’s so uncommon, there are very few good studies which have been completed to educate us about this disease. Kathryn Ruddy, M.D., an oncologist at Mayo Clinic’s Rochester campus joins us to discuss breast cancer in men and what we should do as primary care clinicians to care for our male patients who may be at increased risk to develop it. We’ll cover how breast cancer in males differs from that in females, its risk factors, how it’s diagnosed, and the survival rates of men with a diagnosis of breast cancer. Specific topics: Prevalence of breast cancer How most breast cancers in men are found The recommended evaluation of a male patient with suspected breast cancer Risk factors for breast cancer in men Treatment for male breast cancer Survival rates for breast cancer in men Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline Guest: Richard E. Hayden, M.D. Host: Darryl S. Chutka, M.D. (@ChutkaMD) Currently reconstructive surgery involves taking the patient’s tissue from one area of their body and using it elsewhere to rebuild diseased or damaged tissue. Regenerative reconstructive surgery will allow the patient to grow their own replacement tissue from stem cells. This has incredible potential for allowing significantly better reconstructive surgical results. Currently regenerative reconstructive surgery is in its infancy, however in the next several years this should develop into a new standard of care for patients who need reconstructive surgery. This podcast features Dr. Richard Hayden, a reconstructive surgeon/otolaryngologist. We discuss the future of reconstructive surgery using regenerative medicine techniques, the difficulties in enabling patient access to regenerative therapies, the education that’s needed for not only providers but also for patients, and the future of regenerative reconstructive surgery. Specific topics discussed: Role regenerative medicine plays and reconstructive surgery Importance in adopting and delivering regenerative care Challenges in current standard of care approaches in reconstructive surgery Difficulties enabling patient access to regenerative therapies Educational needs in regenerative reconstructive surgery The future of regenerative reconstructive surgery Additional educational opportunities from Mayo Clinic: https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/ Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

Guest: Laura J. Orvidas, M.D. Host: Darryl S. Chutka, M.D. (@ChutkaMD) Tonsils and eustachian tubes often get taken for granted until they cause problems. Eustachian tube dysfunction is quite common and usually resolves on its own, however some patients will develop recurrent eustachian tube dysfunction and it can result in recurrent episodes of otitis media, especially in children. Although recurrent tonsillitis used to be the most common indication for tonsillectomy, more children are having this procedure for disordered breathing conditions, such as obstructive sleep apnea. In this episode, we’ll discuss disorders of the eustachian tube and tonsils with Laura J. Orvidas, M.D., an otolaryngologist at the Mayo Clinic. Specific topics discussed: Purpose of the eustachian tube Definition of eustachian tube dysfunction Physical exam findings of eustachian tube dysfunction Recurrent eustachian tube dysfunction in children and potential for recurrent episodes of otitis media When pressure equalization tubes are indicated Relationship between pharyngitis and tonsillitis Viral versus bacterial causes of tonsillitis How to suspect a peritonsillar abscess Indications for tonsillectomy Management of tonsil stones Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

This episode is shared from Mayo Clinic Q&A and was recorded in May 2021. To claim credit visit: https://ce.mayo.edu/covid19podcast Guest:  Gregory A. Poland, M.D. (@drgregpoland) Host: DeeDee Stiepan (@deedeestiepan) COVID-19 cases are falling in the U.S. because 245 million doses of one of the available COVID-19 vaccines have been administered, according to Dr. Gregory Poland, an infectious diseases expert and head of Mayo Clinic's Vaccine Research Group. "But at the same time, there are still people who need more information about the safety and the value of getting a COVID-19 vaccine," says Dr. Poland. While still hopeful, Dr. Poland says he's concerned herd immunity won't be reached in the U.S. through vaccination. And that will mean more tragic deaths due to COVID-19 infection. "My guess is, because we're such an interconnected global community until everybody's safe, none of us are safe. And we're going to likely see continued circulation of the virus, and that virus will seek out whoever is not immune," says Dr. Poland. In this Mayo Clinic Q&A podcast, Dr. Poland also addresses when we will need COVID-19 vaccine boosters will be needed and the latest on masking guidelines from the Center for Disease Control and Prevention. Plus, he will provide an update on COVID-19 treatments and how to handle those who want to visit a newborn baby. AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19 Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline Guest: Dennis Wigle, M.D., Ph.D. (@DrWigle) Host: Darryl S. Chutka, M.D. (@ChutkaMD) Regenerative Medicine has some amazing capabilities and in the near future, it’s likely to significantly change how we practice medicine. It faces some challenges in educating both the medical community as well as the general public regarding its current realistic capabilities. There are many unsubstantiated claims made by practitioners to the public regarding the benefits of regenerative medicine therapy. We’ll discuss how the true potential of regenerative medicine is conveyed to both clinicians and the public with Dr. Dennis Wigle, a thoracic surgeon and chair of the Division of General Thoracic Surgery at the Mayo Clinic. We’ll discuss some of the common misperceptions of regenerative medicine and how a consultation service can educate both the public and medical community regarding the benefits of regenerative medicine. Specific topics discussed: How to provide education to the public and the medical community When and why the regenerative consultation service was formed How the regenerative medicine consultation service works Common misperceptions community regarding the realistic benefits of regenerative medicine  Additional resources: For more information about Mayo Clinic’s Regenerative Medicine Consult Service, visit: https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/regenerative-medicine-consult-service  Additional educational opportunities from Mayo Clinic: https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/ Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

To claim credit for this episode, visit: www.ce.mayo.edu/regmedonline Guest: Fredric B. Meyer, M.D.; Andre Terzic, M.D., Ph.D. Host: Darryl S. Chutka, M.D. (@ChutkaMD) Imagine a patient who has suffered a massive myocardial infarction leaving a significant amount of damaged and non-functioning ventricular myocardium. Treatment for this patient’s subsequent congestive failure does not involve diuretics and beta blockers but rather an injection of the patient’s modified stem cells into surrounding viable ventricular myocardium resulting in the regeneration of new, functioning myocardial cells restoring the cardiac output. This is not science fiction but represents ongoing work by investigators in Regenerative Medicine. This week’s podcast will explore this amazing field of medicine which has the potential to change how medicine is practiced. We’ll discuss the origins of regenerative medicine, what currently be done in regenerative medicine as well as the potential for the future. Our guests today are Andre Terzic, M.D., Ph.D., director of the Mayo Clinic Center for Regenerative Medicine and Fredric B. Meyer, M.D., a neurosurgeon and the Executive Dean for Education at the Mayo Clinic.  Specific topics discussed: When the field of regenerative medicine began Which current medical conditions can currently be managed with regenerative medicine How to determine which patients have potential for regenerative medicine therapies Additional educational opportunities from Mayo Clinic: https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/education https://college.mayo.edu/academics/biomedical-research-training/phd-program/tracks/regenerative-sciences/ Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

This episode is shared from Mayo Clinic Q&A and was recorded in April, 2021 Guest:  Gregory A. Poland, M.D. (@drgregpoland)  Host: Halena M. Gazelka, M.D. (@hmgazelkamd)  While the number of people being vaccinated for COVID-19 is dropping, the Centers for Disease Control and Prevention and other medical experts continue to strongly encourage people to get vaccinated for COVID-19. And that means that those who are being vaccinated with the Moderna and Pfizer COVID-19 vaccine should get their first and second doses on schedule. “About 8% of people who got their first dose have not returned for the second dose and this is concerning when you're getting close to 1 in 10," says Dr. Gregory Poland, an infectious diseases expert and head of Mayo Clinic's Vaccine Research Group. "When you measure in the short term, one dose in a healthy person offers about 80% protection. But that's not 95% protection, like you get after two doses." In this Mayo Clinic Q&A podcast, Dr. Poland expands on why people need that second COVID-19 vaccine dose and he talks about whether people should mix and match the different COVID-19 vaccines for their second dose. He also speaks about the status of COVID-19 vaccines for young people, and he addresses listener questions about traveling, being together after vaccination, and the latest rise of additional COVID-19 variants. AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19 Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

Guest: Tobias S. Kohler, M.D., M.P.H. Host: Darryl S. Chutka, M.D. (@ChutkaMD) Erectile dysfunction not only causes lifestyle changes, but it may also be the first symptom of peripheral vascular disease. Since many men are reluctant to mention erectile dysfunction to their healthcare provider, it’s important for us to ask our patients whether it is a problem and be knowledgeable in the appropriate evaluation of patients who have it. This reluctance may cause many to seek out readily available but ineffective treatments from questionable sources, even though there are a variety of proven, effective treatments that can be prescribed. Tobias S. Kohler, M.D., M.P.H., a Mayo Clinic Urologist, joins us to discuss the impact of erectile dysfunction, the currently available effective treatments, as well as the unproven, ineffective products currently being used. Specific topics discussed: The first historical appearance of treatments for erectile dysfunction Most common causes of dysfunction Appropriate evaluation of patients who present with erectile dysfunction Review of the currently available effective treatment options Reasons men are reluctant to mention the topic of erectile dysfunction to their provider Review of some ineffective treatments currently being promoted Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

This episode is shared from Mayo Clinic Q&A and was recorded on April 19, 2021. To claim credit visit: https://ce.mayo.edu/covid19podcast Guest:  Gregory A. Poland, M.D. (@drgregpoland) Host: Halena M. Gazelka, M.D. (@hmgazelkamd)  Dr. Gregory Poland, an infectious diseases expert and head of Mayo Clinic's Vaccine Research Group says COVID-19mutations and the virus spread are happening because of people who don't wear masks, who don't get vaccinated and who don't adhere to safety recommendations. "I believe that we should be radically transparent and honest," says Dr. Poland. "The more time this virus passes through one person after another, the more likely it continues to mutate. As a result of those mutations, two things are happening. Some of the mutations are making vaccines and plasma monoclonal antibodies less effective. The other thing is that the virus will likely become something that we have to live with for the rest of our lives." Dr. Poland reminds people that vaccine protection is not 100%. Breakthrough infections can occur. "Remember that in the clinical trials, 95% means that compared to unvaccinated people, your risk is reduced by 95% — not 100%," he says. "You might have a mild case of COVID-19,but you can still spread it to others, including those who are immune compromised, such as cancer patients. That's why we continue to wear masks until we get very widespread immunization." In this Mayo Clinic Q&A podcast, Dr. Poland talks more about breakthrough infections and the Johnson & Johnson COVID-19 vaccine pause, and he answers listeners' questions. AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19 Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.