The Proof with Simon Hill

Episode #331. Are you getting the right balance of omega-3 and omega-6 fats in your diet? Join me as I sit down with leading scientists to explore the role these essential fatty acids play in your health. From brain development and cognitive function to heart health and inflammation, we unpack how these fats impact your well-being and address common misconceptions about omega-6 fats.You’ll hear from top voices in nutrition, including Dr Bill Harris, Dr Joel Fuhrman, Dr Ayesha Sherzai, Dr Dean Sherzai, Dr Gary Fraser, Dr Phillip Calder, and Dr Kristina Harris. Each expert shares valuable insights into how omega-3s and omega-6s influence everything from cognitive function to heart disease.We cover: Introduction to Omega-3 and Omega-6 Fatty Acids (00:00) What is Omega-6 and Why the Body Needs It (01:06) What is Omega-3 and Do We Really Need It? (12:29) The Importance of Optimising Omega-3 Consumption (42:50) Understanding DHA and EPA: Why Are They Essential? (50:01) Are Omega-3s the Most Important Fatty Acids for Brain Health? (55:44) APOE4 and Omega-3 Supplementation: What You Need to Know (1:08:50) Low Omega-3 Index and Neurological Problems in Seventh-day Adventist Church Members (1:15:00) Omega-3 Supplementation vs Fatty Fish: What Does Research Indicate? (1:21:53) Understanding Essential Fats: Benefits and Sources (1:27:25) Low Conversion Rates: From ALA to EPA & DHA Explained (1:31:39) The Importance of Monitoring Omega-6 Intake (1:37:03) The Link Between Omega-6 Fatty Acids and Inflammation (1:40:55) Major Omega-6 Food Sources and Healthier Alternatives (1:45:45) Balancing Omega-3 & Omega-6 to Reduce Inflammation (1:50:25) The Health Implications of Replacing Saturated Fat with Linoleic Acid (1:53:48) Polyunsaturated Fats and Cardiometabolic Health (1:58:19) How Omega-3 & Omega-6 Influence Insulin Resistance and Blood Pressure (2:01:44) The Long-Term Impact of Consuming Polyunsaturated Fats (2:06:32) Why You Should Measure Your Omega-3 Levels (2:10:07) DHA and EPA: Food Sources and Effective Supplementation (2:14:20) What Forms of DHA and EPA Supplementation Are Most Effective? (2:18:37) How to Properly Store DHA and EPA Supplements (2:20:27) Pregnancy and Omega-3s: Essential Benefits (2:21:33) Supplementing Omega-3s During Pregnancy: Guidelines (2:29:55) Omega-3 Supplementation Protocol: A Comprehensive Guide (2:38:16) Outro (2:52:15) Thank you for tuning in, and for your ongoing commitment to your health. If you found this episode helpful, please share it with someone who could benefit from it.This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.LMNTStay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the Plants

Episode #330. Uncover the key foundations of a healthy diet and learn how to reduce your risk of chronic disease. What does it take to truly eat well? How do you stay healthy in a food system that prioritises profit? In this episode, originally recorded for Sigma Nutrition Radio, I answer these questions and more.Learn practical, science-based strategies for building healthier eating habits that can have a lasting impact on your well-being. Tune in to explore topics like nutrition, chronic disease prevention, and how to make informed dietary choices for better long-term health.Specifically, we discuss: Introduction (00:00) Simon’s Background and Journey into Nutrition Science (01:26) The Importance of Science and Objectivity in Nutrition Advice (08:38) Barriers to Healthy Eating and Population-Level Solutions (16:06) Challenges of Adopting Plant-Based Diets and Solutions (30:38) Omega-3 Fatty Acids: Health Benefits and Plant-Based Sources (38:17) Conclusion and Final Thoughts on Nutrition and Health (47:21) This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.WHOOPWhoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.MomentousMy go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com.Want to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #329. Boost metabolic health and prevent disease with expert insights from an all-star lineup of scientists. Learn key strategies for improving metabolic health, including metabolic flexibility, muscle health, and the critical roles of diet and exercise in preventing type 2 diabetes and fatty liver disease.In this episode, you’ll hear from a distinguished panel of specialists including applied exercise physiologist Inigo San Millan, PhD; skeletal muscle expert Don Layman, PhD; type 2 diabetes authority Roy Taylor, PhD; dietitian and researcher Andrea Glenn, PhD, RD; nutrition scientist Alan Flanagan, PhD; nutrition scientist and endocrinologist Christos Mantzoros MD, DSc, PhD; and physician and researcher Richard Johnson, MD.Specifically, we discuss: Intro (00:00) What is Metabolic Health (01:35) Metabolic Health, Mitochondria, Defining 'Metabolise', Metabolic Flexibility (07:02) The Importance of Skeletal Muscle for Metabolic Health (20:03) Exercise for metabolic health ****Zone 2 (28:36) Twin Cycle Hypothesis (56:45) Understanding the Personal Fat Threshold (01:08:15) Summary of the DiRECT Trial: Examining the Twin Cycle Hypothesis with Roy Taylor (01:17:08) Are DASH, Nordic, Mediterranean, and Portfolio diets good for preventing and managing diabetes? (01:36:46) Understanding Non-Alcoholic Fatty Liver Disease and Its Development (01:42:39) The Science of Hepatic Fat Oxidation (01:49:37) Consequences and Effects of Fatty Liver Disease (01:55:14) Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes (02:00:42) Combination of Fructose and Saturated fat on Metabolic Health (02:13:21) Type of fat and its effect on Metabolic Health (02:17:35) What cause Metabolic Health: fat or fructose (02:24:01) New Fat Storage Mechanisms - Personal Fat Threshold (02:27:50) Modern Techniques for Accurate Body Fat Measurement (02:31:52) Health metabolic biomarkers (02:36:51) Ectopic fat (02:38:19) Fat storage and metabolic health (02:39:10) Evolutionary Insights into Human Fat Storage (02:42:02) Fatty Liver Disease (02:45:46) Outro (2:57:46) Connect with today’s guests and listen to their previous episodes at the links above.This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.WHOOPWhoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.LMNTStay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon.Want to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary Two-Week Meal Plan and high-protein Plant Performance recipe book

Episode #328. Are eggs a superfood or a ticking time bomb? The answer is in your genes. Join me to unpack the surprising science of how eggs affect your health depending on your genetic makeup, helping you understand if they’re safe for you.Discover the two tests you can take to find out if you’re among the 30% of people who are cholesterol hyper-absorbers. You’ll also learn the difference between dietary and blood cholesterol, why cholesterol absorption varies, and what steps to take based on your test results.Specifically, we discuss: Introduction: Are Eggs Superfoods or Cholesterol Bombs? (00:00) Understanding Cholesterol: Dietary vs. Blood Levels (01:25) The Genetic Factors Influencing Cholesterol Absorption (04:31) Identifying Cholesterol Hyperabsorbers: Are You One? (09:20) Testing Methods for Cholesterol Sensitivity (12:41) Dietary Tips for Cholesterol Hyperabsorbers (13:59) Key Insights: 5 Critical Facts About Eggs and Heart Health (18:06) Concluding Thoughts (21:23) Head to the full show notes for supporting studies and phytosterol testing options.This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.WHOOPWhoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.ShopifyShopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof.Want to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #327. Butter, bone broth, and eating like our ancestors: join me on The Ellen Fisher Podcast to bust some prolific nutrition myths.Tune in to unpack my core nutrition philosophy, evaluate how popular diets can impact your health, and examine some key foods that are either idolised as superfoods or condemned as dangerous. If you have questions about keto, carnivore, antinutrients, or other hot nutrition topics, this episode is for you.Specifically, we discuss: Introduction (00:00) Exploring Personal Nutritional Philosophy (02:31) Science's Role in Nutritional Understanding (06:33) Integrating Science and Nature in Dietary Patterns (10:55) Ancestral Diets Explained (14:40) Saturated Fats and ApoB: Their Crucial Role in Diet (21:03) Strategies for Reducing Saturated Fat and ApoB Levels (26:49) Analyzing Evidence Against Saturated Fat Claims (30:16) Polyunsaturated Fats: Health Impacts Unveiled (40:13) Processed Foods and Overconsumption Risks (47:33) Butter and Saturated Fats: Revealing the True Health Effects (49:26) Comparative Analysis of Various Diets and Health Outcomes (53:30) Debunking Anti-Nutrient Myths (01:04:36) Debating Contrasting Nutritional Perspectives with Paul Saladino (01:16:07) Saturated Fats Comparison: Coconut vs. Red Meat (01:22:26) The Importance of Personal Health Metrics (01:25:15) Evaluating Plant Milks and Processed Food Alternatives (01:29:26) Beef Liver Consumption and Nutrient Toxicity Risks (01:31:15) Critiquing Vegan Diets and Low-Fat Diet Misconceptions (01:36:54) Holistic Health and Longevity: Defining the Ultimate Goal (01:45:32) Conclusion and Key Takeaways (01:48:07) Discover more of the Ellen Fisher podcast at https://www.ellenfisher.com/podcast, or listen to her previous appearance on The Proof.Visit the full show notes for more insights and supporting studies.This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.WHOOPWhoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.LMNTStay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon.Want to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #326. Could the oils you’re using in the kitchen be increasing your risk of chronic disease? Explore the essential facts about dietary fats and how they affect your health markers in this focused deep dive.Learn which oils to eat and avoid, how to adjust your diet for optimal intake, and how fats can make the difference between health and chronic disease.Specifically, I cover: Introduction to Dietary Fats (00:00) Types of Fats Explained (02:27) Essential vs. Non-Essential Fats - What's the Difference? (07:54) Fats and Cardiovascular Health - Unveiling the Connection (10:32) How Dietary Fats Influence Blood Pressure (17:47) The Fat-Inflammation Link (20:29) Exploring the Relationship Between Fats and Insulin Resistance (26:03) Long-Term Health Outcomes of Dietary Fat Consumption (29:51) Optimising Fat Intake: Practical Dietary Recommendations (36:22) Wrapping up and Final Thoughts (41:25) Head to the full show notes for additional resources and supporting studies.This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.WHOOPWhoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.MomentousMy go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com.Want to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #325. Fish oil supplements: harmful or heart-healthy? Learn about the risks and benefits of omega-3 supplementation, including an analysis of a new study that’s been making waves.Discover how to test your omega-3 levels, how to achieve the optimal index, and my supplement recommendations for a healthy heart and planet.Specifically, I cover: Introduction to Omega-3 Fatty Acids and Fish Oil Supplements (00:00) New Research Reveals Fish Oil's Impact on Cardiovascular Health (01:03) Challenging Assumptions - A Different Take on the Fish Oil Study Results (05:14) Dr. Bill Harris Weighs In - Expert Opinions on Omega-3 Benefits (09:03) How Can I Increase My Omega-3 Levels? Practical Advice for Everyday Life (17:26) Omega-3 Supplement Strategy (18:50) Comparing Sustainable Omega-3 Sources: Algae Oil vs. Fish Oil (24:05) How much omega-3 is too much (25:58) Does the form of DHA and EPA matter? (28:00) Does EPA DHA ratio matter? (28:44) Omega-3 Supplementation for Vegans and Vegetarians (31:50) Key Takeaways and Recommendations for Omega-3 Supplementation (35:55) Head to the full show notes for additional insights and supporting resources.This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.WHOOPWhoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.LMNTStay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon.Want to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #324. A crash course for carnivores: let’s talk saturated fat, heart disease, and protein as I’m interviewed on Mark Bell’s Power Project.Do you need to change your diet if you’re feeling good? Can you be overweight and healthy? What simple changes can meat eaters make to improve their long-term health? Hear my answers to these questions and more in this episode.We cover: Introduction and Podcast Overview (0:00) Finding Common Ground in Nutritional Science (02:15) Genetic Testing and Personalised Nutrition (06:48) Heart Health Unveiled: The Saturated Fat and ApoB Connection (10:40) Nutritional Strategies vs Medication for Lowering ApoB (18:39) Understanding Epidemiology Studies on Red Meat (27:07) Practical Tips for Transitioning from Animal to Plant Protein (42:05) A Personal Journey with Nutrition (48:53) Weight Loss and Metabolic Health Insights (53:41) Exploring Health Impacts of an All-Meat Diet (01:02:59) Comparing Plant and Animal Protein Bioavailability (01:12:13) The Role of Protein in Satiety (01:16:44) Addressing Seed Oils (01:20:16) Incorporating Vegetables and Plant Proteins for Optimal Health(01:27:30) Carnivore Diet vs Plant-Based Diet Discussion (01:33:34) The Undeniable Importance of Resistance Training (01:39:13) Ensuring Adequate Intake for Thyroid Health (01:47:23) Final Thoughts and Farewell (01:50:12) In this episode, we discuss the importance of getting regular blood tests. Download my free blood test guide to get started.Connect with Mark Bell, Nsima Inyang, and Andrew Zaragoza on Instagram. If you’re interested in hearing more of Mark Bell’s Power Project, head to https://powerproject.live/.This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.WHOOPWhoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.Cozy EarthSleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off.ShopifyShopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof.Want to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #323. Oreo cookies or statins – which is more effective in reducing LDL cholesterol? The results from one study might surprise you. Join me as I sit down with Oxford PhD graduate and Harvard Medical student Dr Nick Norwitz to discuss the lipid energy model, what it has to do with Oreos, and how different diets affect your health.You’ll learn about Dr Norwtiz’s health journey, including his experience with inflammatory bowel disease and the ketogenic diet. We discuss cholesterol management and cardiovascular disease risk, lean mass hyper-responders, and statins. This episode is an important and informative reflection on scientific curiosity and misinformation.Specifically, we discuss: Introduction (00:00:00) The Importance of Curiosity in Scientific Progress (04:39) Exploring the Oreo vs. Statin Experiment on Lean Mass Hyper Responders (08:52) Scientific and Clinical Impact of the Oreo Study (25:03) Addressing Criticisms and Misinterpretations of the Study (34:47) Navigating Statin Discussions on Social Media (40:27) Debunking Claims About PCSK9 Inhibitors (53:18) Challenging Misinformation in Health Communities (59:15) The Lipid Energy Model and Lean Mass Hyper Responders Explained (01:06:59) Defining Lean Mass Hyper Responders: Key Terminology (01:14:19) Practical Advice for Lean Mass Hyper Responders (01:30:35) The Carnivore Kid: An Intriguing Case Study (01:41:48) Personal Struggles with Ulcerative Colitis and Starting Keto (01:45:24) Balancing Medication and Personal Health Choices (01:50:31) Debating Dietary Interventions for Inflammatory Bowel Disease (02:11:09) Challenges in Dietary Research and Medical Interventions (02:25:55) Introducing the Lipid Energy Model and Its Mechanisms (02:34:49) Debating the Validity of the Lipid Energy Model (02:44:29) Long-Term Effects of Ketosis and Carb Restriction (02:52:31) Critiques and Limitations of the Lipid Energy Model (02:57:17) ApoB-Containing Lipoproteins and Atherosclerosis (03:03:50) Current Research and Future Directions on LMHR (03:06:41) Exploring Inflammatory Responses to Fibre (03:16:12) The Link Between Saturated Fats and Heart Disease (03:20:49) Closing Thoughts on Effective Scientific Communication (03:25:29) The Lean Mass Hyper Responders Debate: Addressing Frustrations (03:32:32) Understanding Carbohydrate Reintroduction Physiology (03:46:58) Diet-Specific Strategies to Lower ApoB (03:55:16) Examining Claims About ApoB and Cardiovascular Disease (04:01:50) Trade-offs in Lowering ApoB Levels (04:12:54) Exploring the Link Between All-Cause Mortality and ApoB (04:22:42) Lean Mass Hyper Responders and ApoB: A Unique Profile (04:44:54) Concluding Thoughts and Future Discussion Topics (04:48:10) Connect with Nick Norwitz, PhD on Twitter/X, Instagram, and YouTube. Make sure to check out the full show notes for additional resources and supporting studies.This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.LMNTStay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon Hill

Episode #322. Did you know that 30% of cancers are related to obesity? Join me as I sit down with Harvard Professor and endocrinologist Dr Christos Mantzoroz to discuss fatty liver disease, metabolic health, and hormones.You’ll learn about why so many people are obese and whether you can be overweight and healthy. Dr Mantzoroz breaks down budget-friendly ways to evaluate your metabolic health, explains how hormones affect your weight, and offers his insight on how to treat obesity. Overall, this episode is a masterclass in metabolic health and fatty liver disease.Specifically, we discuss: Introduction to The Latest Obesity Research Findings (00:00) The Evolving Understanding of Obesity Science (03:49) Uncovering New Fat Storage Mechanisms (10:57) Modern Techniques for Accurate Body Fat Measurement (15:02) Why Maintaining Weight Loss Is So Challenging (20:01) Evolutionary Insights into Human Fat Storage (25:12) How Leptin Regulates Energy Balance and Health (29:17) New Approaches to Break Through Weight Set Points (39:27) Environment's Role in Weight Gain Beyond Diet (45:49) Decoding the Genetics of Fat Storage and Metabolism (52:59) Non-Alcoholic Fatty Liver Disease Explained (55:40) Evidence-Based Nutrition for Optimal Liver Health (01:05:25) Promising Advances in Non-Invasive Liver Tests (01:10:49) Oestrogen's Impact on Metabolism (01:20:14) The Link Between Liver Fat and Insulin Resistance (01:22:04) Addressing America's Growing Metabolic Health Crisis (01:26:11) Outro (01:27:11) Connect with Christos Mantzoros, MD DSc PhD h.c. mult. on LinkedIn, and discover his work here.This episode is brought to you by:38TERAConsider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.EimeleEimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.WHOOPWhoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.Cozy EarthSleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off.Want to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book