Emmanuel Dzotsi, a producer, brings a poignant piece from the 'Black Lives Matter' mural demolition. Aviva DeKornfeld shares Ranjani Srinivasan's harrowing journey navigating ICE after her visa was revoked, capturing the panic of international students. Laura Starecheski recounts a gripping court hearing against the Trump administration's transgender military ban, revealing the stakes for those involved. This insightful discussion highlights the emotional and political turbulence defining our current moment.

Ryan Knighton, a blind author, shares humorous stories about his experiences navigating blindness and connecting with his daughter. Comedian Tig Notaro recounts her hilarious and unexpected encounters with pop star Taylor Dayne, adding a surprise twist. David Rakoff reflects on the invisible bodily processes he faced during cancer treatment, presenting a poignant view of health struggles. Lastly, David Sedaris offers witty observations about his coffee-buying experience, revealing the humor in everyday life.

Comedian Daniel Sloss, known for his jigsaw puzzle analogy that has led to many breakups, discusses how comedy can inspire self-reflection in relationships. Former nurse Kwaneta Harris shares her unique experience of offering medical advice to inmates, illustrating resilience and the complexities of access to healthcare behind bars. Together, they explore how unconventional perspectives can change lives and the power of humor and shared struggles in understanding love and health.

Join Sarah Koenig, the producer behind Serial, as she delves into the legacy of her father, a trailblazing advertising copywriter known for iconic slogans. She uncovers surprising family stories about creativity and industry rivalries. Also, hear from reporter Mary Wiltenburg as she poignantly narrates the struggles of two Tanzanian brothers navigating identity and belonging, emphasizing the complex questions of where we come from. Both stories reflect the deep ties between legacy, memory, and the search for self.

Liz Flock, a reporter known for her investigation into the A Gay Girl in Damascus hoax, joins producer Dana Chivvis to discuss the strange world of online deception. M. Gessen, an author and journalist, sheds light on 'bully lies' in politics, while Ike Sriskandarajah humorously defends the case for lying in certain contexts. The conversation weaves through personal anecdotes and the bizarre motivations behind unnecessary lies, leaving listeners to ponder the complexities of truth in our increasingly digital lives.

Zach Mack, a reporter, shares a candid journey of attempting to mend his strained relationship with his father through an unusual bet on political predictions. They confront radical beliefs inspired by conspiracy theories and navigate the emotional tensions that arise from differing ideologies. Family dynamics come to the forefront as Zach's mother and sister offer their perspectives. The story reflects humor, disappointment, and the complexities of acceptance, showcasing the fragile yet vital bonds of family amidst challenging times.

Valerie Kipnis, a producer known for her engaging storytelling, shares insights on managing street parking chaos in a New York neighborhood. She highlights the struggles and humorous dynamics between long-time residents and newcomers as community tensions rise over limited parking. The discussion offers a unique lens on urban life, revealing how one man's efforts to ease frustrations can foster a sense of connection among neighbors. Kipnis' anecdotes provide a poignant yet entertaining look at the everyday challenges that bind communities together.

Armando Ianucci, the British comedy maestro behind hits like Veep, dives into dark humor's role in navigating existential dread, reflecting on how laughter can provide fresh perspectives at turbulent times. Susan Burton, an editor, opens up about her journey through perimenopause, giving voice to the emotional upheavals many face during this transition. Valerie Kipnis engages with Ukrainian soldiers, sharing their vulnerabilities and hopes amidst ongoing conflict, highlighting the personal impact of war in the face of political uncertainty.

Josh Johnson, a comedian, dives into the thorny topic of spanking, reflecting on his own childhood and its implications. Etgar Keret, a celebrated writer, shares a whimsical yet thought-provoking tale about a bus driver who won't open the doors for late passengers, exploring themes of fairness and human connection. John Mulaney, a renowned actor and comedian, brings his storytelling flair, leaving listeners chuckling while tackling the intricacies of everyday life with humor and heart.

Lilly Sullivan, a producer on the show, shares a humorous family tale about her parents' first meeting, revealing surprising twists that reshape her understanding of family narratives. Musician Mike Comite reflects on a critical moment at the Bonnaroo festival, where a unique connection with Weezer's frontman changed the course of his career, highlighting the impact of vulnerability in artistic growth. Both guests explore how seemingly small events can dramatically alter lives and perspectives.