Longevity by Design

In this insightful episode of Longevity by Design, hosts Dr. Gil Blander and Ashley Reaver welcome Dr. Tony Wyss-Coray, a distinguished expert in neurology and brain aging. Dr. Wyss-Coray shares his journey from a childhood fascination with nature to becoming a leading figure in neuroscience and immunology. His initial interest in farming evolved into a passion for understanding the complexities of the human brain, particularly in the context of aging and neurodegenerative diseases.Dr. Wyss-Coray discusses his groundbreaking research on Alzheimer's disease and the aging brain. He dives into the intriguing discovery that factors in young blood can rejuvenate older brains, offering potential pathways for treating age-related cognitive decline. This revelation has significant implications for understanding and potentially mitigating the effects of aging on the brain.The episode also explores Dr. Wyss-Coray's transition from Switzerland to the U.S., highlighting the cultural and scientific opportunities that influenced his career. His journey underscores the importance of interdisciplinary research and collaboration in advancing our understanding of complex medical challenges like Alzheimer's disease. This conversation provides a fascinating glimpse into the intersection of immunology, neurology, and the quest to unlock the secrets of longevity.Listen to all episodes of Longevity by Design at https://info.insidetracker.com/longevitybydesign Episode timestamps:Introduction: 0:00-2:12Why Dr. Tony Wyss-Coray became a scientist: 02:13-03:35Dr. Tony Wyss-Coray’s career journey studying immunology, neuroscience, and aging: 03:36-07:02Dr. Tony Wyss-Coray’s personal story on why he decided to stay in the US: 07:03-11:20Dr. Tony Wyss-Coray’s story on becoming the founder of three biotech companies and what they do: 11:21-15:12Introduction to Dr. Wyss-Coray’s research on proteomics and organ-specific aging: 15:13-15:52What is proteomics: 15:53-16:39What are the SomaLogic and Olink technologies for measuring proteins: 16:40-19:37What are the links between blood-based proteins, organ-specific biological aging, and chronic disease risk: 19:38-28:35Is aging a disease: 28:36-31:01The three waves of aging based on proteomic analysis: 31:02-37:29Are changes in blood proteins the cause or effect of aging: 37:30-43:46What are the effects of parabiosis and blood transfusion on gene expression and aging: 43:47-50:58The future of blood transfusions and synthetic drugs for improving healthspan and preventing neurodegenerative diseases: 50:59-55:07Are the effects of parabiosis or blood transfusions short-term, mid-term, or long-term: 55:08-59:17Proteomics for understanding organ aging, identifying potential drug targets, and young blood transfusions for rejuvenation: 59:18-01:01:58Biological aging of organs: 01:01:59-01:10:29What are the effects of fat tissue or obesity on metabolic health and mortality: 01:10:30-01:12:06What is the effect of accelerated brain aging on cognition and neurodegeneration: 01:12:17-01:15:52What can people do themselves to identify if they have accelerated brain aging: 01:15:53-01:18:27Sleep improves blood biomarkers: 01:18:28-01:19:09Top tip for healthspan: 01:19:10-01:21:44

How can you increase NAD+ levels? And do higher NAD+ levels really lead to better metabolic health? What does the research say on their benefits for longevity? These topics and more are discussed in the latest episode of Longevity by Design with Dr. Joe Baur. Dr. Baur, Professor at the Perelman School of Medicine of the University of Pennsylvania, has made key contributions to the understanding of how metabolism and dietary factors influence longevity, for example, resveratrol’s effect on insulin sensitivity. His lab looks at small molecules like NAD+ to understand how they can mimic the health-promoting effects of caloric restriction in rodents. Listen to all episodes of Longevity by Design at https://info.insidetracker.com/longevitybydesign Episode highlights8:08-10:13: What are the Potential Benefits of Resveratrol Supplements? 17:36-19:53: How Does NAD Affect Metabolism?22:49-25:13: Do NAD+ levels decline with age?  25:14- 31:27: How to Combat Declining NAD Levels as You Age  43:54- 49:12: How do NAD Analogs Affect Target Tissues? 50:11-51:06: What are the potential health benefits of taking NMN?  54:17- 1:04:21: Safety, Dosage, and Benefits of NMN + NR Supplements 1:04:22-1:04:31: Should you take NMN supplements? 

Dr. Eric Verdin, CEO of The Buck Institute, discusses the latest updates in longevity research including the future of anti-aging drugs, the question of whether aging is a disease, and the potential for a maximum lifespan. He also shares insights on senescence and senolytics, the impact of genetics and lifestyle on longevity, and the importance of optimizing lifestyle factors for a longer and healthier lifespan.

Dr. Nick Burd, a skeletal muscle physiologist, discusses the importance of muscle mass, protein intake, and exercise. He explains the optimal timing of protein consumption after exercise, the benefits of whole food protein over powders, and the significance of distributing protein throughout the day.

Dr. Sara Gottfried, MD from Harvard Medical School and completed residency at UCSF, talks about tracking data for precision medicine, impacts of birth control pills on women's health, erectile dysfunction as a warning sign, hormone replacement therapy for women, tracking cortisol levels, consequences of early menopause, sleep tracking with wearables, challenges of ketogenic diet, significance of testing for improved health outcomes, and the balance of weightlifting and cardio.

Cholesterol expert Ashley Reaver discusses dietary cholesterol's impact on blood cholesterol levels and navigating high cholesterol family history. Dr. Blander explains the importance of VO2max for heart health, quality sleep, and NAD+ precursors.

Dr. Bartek Nogal discusses genetic predispositions to conditions of aging with Dr. Gil Blander, focusing on improving healthspan using DNA insights. They cover bone mineral density, epigenetic age acceleration, cognitive decline, risk of elevated ApoB, grip strength, and more. Understanding genetic predispositions helps fine tune wellness plans.

Dr. Joseph Maroon, Neurosurgery professor at the University of Pittsburgh Medical Center and longtime team neurosurgeon to the Pittsburgh Steelers, shares interesting science on Alzheimer's disease, oxidative stress, and brain health. He discusses sleep's role in preventing Alzheimer's and gives lifestyle advice. He also talks about concussions, new concussion-detection technology, VO2max, and how triathlons saved his life.

GLP-1 agonist medications have been a popular topic of discussion recently. While this weight loss drug was designed for obesity, GLP-1 agonists like Ozempic have made their way into Hollywood. This has people questioning their safety and possible health risks, especially in the long run. Are GLP-1 agonists a quick fix for weight loss or a lifetime prescription? Who should be prescribed this medication, and what are the possible side effects? This Longevity by Design episode features an interview with Dr. Spencer Nadolsky—An obesity and lipid specialist physician. Dr. Nadolsky explains how GLP-1 medications cause weight loss, answers questions about safety concerns, and discusses interesting patient stories about how people react to this medication. Dr. Nadolsky has a lot of patient experience with GLP-1 agonist drugs and is very knowledgeable about their current use and future potential. Timestamps:Introduction: (0:00–2:00)Why Dr. Nadolsky became a physician: (2:00–4:13) What is cardiometabolic medicine?: (4:13–5:17)What is a “healthy” metabolism?: (5:17–7:37)How does diet impact glucose regulation: (7:37–10:20)Why has insulin resistance increased in the past decade?: (10:20–11:45)Ethnicity impacts BMI cutoffs: (11:45–12:57)Is obesity a choice?: (12:57–17:40) How socioeconomic status impacts obesity: (17:40–21:30)What's better: A BMI score or a DEXA scan?: (21:30–25:33)How strength training improves healthspan: (25:33–32:32) What a fasting insulin blood test tells you: (32:32–36:58)Health risks of insulin resistance: (35:15–38:08)How insulin resistance can increase ApoB: (38:08–39:25)How does ApoB predict heart disease risk?: (39:25–42:50)Why isn't ApoB included in typical lipid panels?: (42:50–44:25)Behavioral science and clinical practice: (44:25–50:06)How do GLP-1 agonists cause weight loss? (50:06–56:03)Negative side effects of GLP-1 medications: (56:03–57:36)Price of GLP-1s: (57:36–58:53)GLP-1: A short term quick fix or a lifetime prescription?: (58:53–1:02:19)Biggest health myths on social media: (1:02:19–1:08:45)Top tip for healthspan: (1:08:45–end) Longevity By Design is produced by InsideTracker. InsideTracker provides a personalized health analysis and data-driven wellness guide to help you add years to your life—and life to your years. Choose a plan that best fits your needs to get your comprehensive biomarker analysis, customized action plan, and customer-exclusive healthspan resources. Listen to all episodes of Longevity By Design at https://info.insidetracker.com/longevitybydesign

Dr. Mitch Roslin, an expert in insulin resistance and weight management, discusses the causes and prevention of insulin resistance through diet and lifestyle. He shares insights on managing weight and eating optimally for metabolic health, including the ketogenic diet and intermittent fasting. Topics include the role of insulin in the body, preventing insulin resistance, the ideal diet for preventing obesity, and the benefits of walking after meals.