Metagenics Institute Podcast

Lara Briden is a naturopathic doctor and bestselling author of the book Period Repair Manual - a practical guide for treating period problems with nutrition, supplements, and bioidentical hormones. This year, Lara has released her new book, The Hormone Repair Manual, which explains how to navigate the change of perimenopause and relieve symptoms with natural treatments. In this episode, she explains the ins and outs of ‘second puberty’ and her favourite nutrients to support this time of life, as well as a fascinating evolutionary perspective on menopause. Tune in for a host of clinical gems! Highlights What motivated Lara to write The Hormone Repair Manual? (1:30) The perimenopausal years, aka ‘second puberty’ (4:00) Novel insights into nutrients for hormonal support (15:00) The recalibration process (19:00) Why you shouldn’t drink alcohol during perimenopause (25:30) Debunking the controversy surrounding phytoestrogens (29:00) The evolutionary take on menopause (33:00) Nutrients for perimenopause and menopause (43:00) Discussion regarding hormonal therapy (50:00) *Useful Links and Resources * https://www.larabriden.com/ https://www.larabriden.com/hormone-repair-manual/ Lara Briden on Instagram - https://www.instagram.com/larabriden/ Metagenics on Instagram - https://www.instagram.com/metagenics_anz/

Kara Fitzgerald and her research team were the first to demonstrate potential reversal of biological age in humans by targeting methylation. In their study, the prescribed program included multiple components with documented mechanistic activity on epigenetic pathways. Tune in to hear the details of her research and learn how to influence your epigenetics. Dr. Kara Fitzgerald has a doctorate of naturopathic medicine, and has been published in numerous peer-reviewed journals. She is on faculty at the Institute for Functional Medicine, and is an Institute for Functional Medicine Certified Practitioner. She regularly lectures internationally for several organizations and is in private practice in Sandy Hook, Connecticut. Highlights What motivated Kara to move into epigenetic research? (2:30) Introduction to epigenetic clocks (9:00) What positively impacts our epigenetics? (24:00) Kara details her research (30:00) Methylation adaptogens (35:00) Kara’s hopes for future research (45:00) *Useful Links and Resources * https://www.drkarafitzgerald.com/ For Kara’s list of methylation adaptogens and links to her books: https://www.drkarafitzgerald.com/professionals/methylation-diet-lifestyle/ Kara’s research - https://www.researchgate.net/publication/342929824_Reversal_of_Epigenetic_Age_with_Diet_and_Lifestyle_in_a_Pilot_Randomized_Clinical_Trial Research links: https://www.drkarafitzgerald.com/professionals/research-news-ideas/ My DNA age - https://www.mydnage.com/ HK Epitherapeutics - http://www.hkgepitherapeutics.com/ About Moshe Szyf - http://www.hkgepitherapeutics.com/about/moshe-szyf/ Metagenics Congress - https://metagenicsinstitute.com.au/congress-2021

As an expert in mast cell activation syndrome (MCAS), Dr Tania Dempsey, imparts priceless information regarding the nature and treatment of this insidious condition. Among many insights, Dr Dempsey explains how to distinguish histamine intolerance from MCAS, the impact of this condition on gastrointestinal health, as well as views on the connection between COVID-19 and MCAS. Importantly, Dr Dempsey draws on years of experience to provide advice on the identification and management of MCAS. Dr. Dempsey is Board Certified in Internal Medicine and a Diplomate of the American Board of Integrative and Holistic Medicine. She has served as an attending physician at a large multi-specialty medical practice in White Plains, NY, and since opened AIM Centre for Personalised Medicine. *Highlights * What is MCAS and how prevalent is it? (6:30) Examining the connection between gut health and MCAS (13:00) Histamine intolerance versus MCAS (21:30) Why a personalised diet is important (27:00) MCAS and COVID-19 (38:20) How to spot MCAS (47:20) Stabilising mast cells and avoiding triggers (53:00) **Useful links and resources: Follow Metagenics on Instagram here - https://www.instagram.com/metagenics_anz/ Or on Facebook - https://www.facebook.com/metagenics Website: https://www.drtaniadempsey.com/ LinkedIn: AIM Centre for Personalised Medicine - https://www.linkedin.com/company/armonk-integrative-medicine#:~:text=Tania%20Tyles%20Dempsey%2C%20MD%2C%20founder,Dr. Twitter account: https://twitter.com/drtaniadempsey?lang=en Paper Tania mentions: Afrin LB, Weinstock LB, Molderings GJ. Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome. Int J Infect Dis. 2020;100:327-332. doi:10.1016/j.ijid.2020.09.016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529115/

Science educator, Jason Wilson is the host of The Curious About Cannabis Podcast which answers questions about the world’s most controversial plant – Cannabis. In this episode, Wilson provides an in-depth history lesson on Cannabinoid science, as well as the use of Cannabis extracts for medicinal purposes and the future of Cannabis research. Highlights: Jason’s journey to Cannabinoid research (1:30) A history lesson on Cannabinoid science (14:00) Examining endocannabinoid derangement and supplementation with phytocannabinoids (36:00) The entourage effect (45:00) Lesser known and emerging cannabinoids (55:00) Medicinal cannabis (1:02:00) Directions for future research (1:14:00) Useful links and resources: Follow Metagenics on Instagram here - https://www.instagram.com/metagenics_anz/ Or on Facebook - https://www.facebook.com/metagenics If you are a Healthcare Practitioner in Australia or New Zealand, keep up latest industry news and events by joining our private Practitioner Only Facebook Group - https://www.facebook.com/groups/MetagenicsAU Jason Wilson’s book – Curious About Cannabis: A Scientific Introduction to the World's Most Controversial Plant - https://www.cacpodcast.com/book.html#/

Daniele Piomelli joins us from the University of California, Irvine, where he is the Louise Turner Arnold Chair in Neurosciences and Distinguished Professor of Anatomy and Neurobiology, Pharmacology and Biological Chemistry. Piomelli is the author of over 400 peer-reviewed articles in journals such as Nature, Science, Nature Medicine, PNAS and Nature Neuroscience, three books, and 34 patents. He is also the Director of the Centre for the Study of Cannabis and Editor-in-Chief of Cannabis and Cannabinoid Research, the first peer-reviewed journal entirely dedicated to the study of cannabis, its derivatives, and their endogenous counterparts in the human body. In this episode, he shares a wealth of information regarding the endocannabinoid system and the acylethanolamides, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). Highlights The endocannabinoid system (3:30) The fascinating history of PEA (25:50) The role of OEA in fat digestion (34:00) Zoning in on PEA (42:00) PEA dosage and time to benefit (56:00) Synergism for pain management (59:00) Useful links and resources: Follow Metagenics on Instagram here - https://www.instagram.com/metagenics_anz/ Or on Facebook - https://www.facebook.com/metagenics If you are a Healthcare Practitioner in Australia or New Zealand, keep up latest industry news and events by joining our private Practitioner Only Facebook Group - https://www.facebook.com/groups/MetagenicsAU Daniele Piomelli Google Scholar citations - https://scholar.google.com/citations?user=c0v1zcoAAAAJ&hl=en

Dr Tommy Wood earned his medical degree at the University of Oxford, and subsequently completed PhD in physiology and neuroscience at the University of Oslo. Currently, he holds academic positions at the University of Washington and Institute for Human and Machine Cognition. One of Dr Wood’s research interests is developing easily-accessible methods with which to track human health, performance, and longevity. In this episode, Dr Wood shares a plethora of information regarding the science of longevity, including patterns in ageing, determining biological age, and importantly, whether specific ingredients can increase longevity. *Highlights * The fascination with extending the lifespan (5:00) Looking to the Blue Zones (8:30) The biomarkers of ageing (15:50) Determining your biological age (21:00) Biological drivers of ageing (31:40) Diving into caloric restriction (38:00) Macronutrients for health and longevity (55:00) Ingredients to improve longevity (75:00) Useful links and resources: e.g: For more Metagenics follow us on Instagram https://www.instagram.com/metagenics_anz/ If you're a Healthcare Practitioner in Australia or New Zealand, join our private Facebook group https://www.facebook.com/groups/MetagenicsAU Follow Dr Tommy Wood on Instagram here - https://www.instagram.com/drtommywood/ Genetic testing providers Tommy Wood mentions: Elysium - https://www.elysiumhealth.com/en-us/index Chronomics - https://www.chronomics.com/dna Paper – Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242. PMID: 28336669 Link: https://pubmed.ncbi.nlm.nih.gov/28336669/ Paper – Newman S. Supercentenarians and the oldest old are concentrated into regions with no birth certificates and short lifespans. 2019 Jul. doi: 10.1101/704080 Link - https://www.researchgate.net/publication/334497888_Supercentenarians_and_the_oldest-old_are_concentrated_into_regions_with_no_birth_certificates_and_short_lifespans

In this episode, Nathan had the honour of discussing intestinal permeability and ‘leaky gut’ with renowned gastroenterologist, Dr Eamonn Quigley. He is internationally known for his research on gastrointestinal motility disorders, neurogastroenterology and the gut microbiome and has published more than 800 peer-reviewed articles, reviews, editorials, book chapters and case reports. Quigley is past president of the American College of Gastroenterology and the World Gastroenterology Organisation. His current responsibilities include, but are not limited to, the David M. Underwood Chair of Medicine in Digestive Disorders, Head of Gastroenterology and Hepatology at Houston Methodist Hospital, and Professor of Medicine at both the Institute of Academic Medicine and Weill Cornwell Medical College. *Highlights * Debunking the gut barrier (6:00) Evaluating tests to assess gut permeability (12:40) Does targeting paracellular permeability improve disease? (22:00) The role of the gut microbiome (29:20) Maintaining the gut barrier (33:10) Useful links and resources: e.g: Follow Metagenics on Instagram here - https://www.instagram.com/metagenics_anz/ Or on Facebook - https://www.facebook.com/metagenics Keep up withthe latest industry news and events by joining our private Practitioner Only Facebook Group - https://www.facebook.com/groups/MetagenicsAU Article: Quigley EMM, 2016 – ‘Leaky gut - concept or clinical entity?’ - https://pubmed.ncbi.nlm.nih.gov/26760399/ Article: Camilleri M, 2019 – ‘Leaky gut: mechanisms, measurement and clinical implications in humans’ - https://pubmed.ncbi.nlm.nih.gov/31076401/ Article: Zuo L, Kuo WT, Turner JR - Tight Junctions as Targets and Effectors of Mucosal Immune Homeostasis - https://pubmed.ncbi.nlm.nih.gov/32304780/

For anyone fascinated by the gut-brain connection, this episode is sure to pique your interest. Scott C Anderson is a scientist, science journalist and co-author of the book, The Psychobiotic Revolution. With great enthusiasm, he brings us up to speed on gut-brain axis centred research – from the relationship between gut health and depression, to the role psychobiotics and diet in the management of mental health conditions. ** Highlights ** Origins of research on the gut-brain axis (5:20) Chronic inflammation at the root of mood disorders (11:00) Markers used to assess gut health (14:30) The role of the vagus nerve in gut-brain cross-talk (21:20) Does poor gut health cause depression? (23:40) The relationship between gut health and ASD (28:00) Drawing our focus to cognitive health (33:00) What role does the small intestine play in disease? (37:00) Exploring the use of psychobiotics (42:30) Therapies to keep an eye on (57:25) Useful links and resources: e.g: Book –The Psychobiotic Revolution: Mood, Food, and the New Science of the Gut-Brain Connection Amazon link to purchase book - https://www.amazon.com.au/Psychobiotic-Revolution-Scott-C-Anderson/dp/142621846X Website - http://psychobiotic-revolution.com/ Twitter - https://twitter.com/Psychobiotic Psychology today link: https://www.psychologytoday.com/au/blog/mood-microbe

Looking for a novel approach to exercise for chronic disease populations? You’ve come to the right place. Nathan’s guest, Dr Brendan Scott provides a comprehensive review on blood flow restriction (BFR) training, a technique used to enhance muscular strength and hypertrophy through resistance and aerobic exercise. Dr Scott is a Senior lecturer in Strength and Conditioning at Murdoch University and has a keen interest in hypoxic and blood flow restriction training strategies. *Highlights * The origins of BFR training (6:05) What happens when you change blood flow characteristics (11:20) Benefits of BFR training (16:55) Using BFR in aerobic exercise (27:30) Safety concerns for this form of exercise (31:50) The equipment requirements (40:20) The future of BFR research (50:20) *Useful links and resources: * Dr Brendan Scott’s Murdoch University profile, and list of publications - http://profiles.murdoch.edu.au/myprofile/brendan-scott/ Join the Metagenics Practitioner Only Facebook Group here - https://www.facebook.com/groups/MetagenicsAU/permalink/1250761761953759/?comment_id=1251570225206246 Follow Metagenics on Instagram - https://www.instagram.com/metagenics_anz/ or Like us on Facebook - https://www.facebook.com/metagenics

Following his ME/CFS diagnosis 20 years ago, Ashok Gupta went on a journey to reclaim his health. His road to recovery emphasised the importance of retraining his brain and he subsequently created a 7-step program to promote neuroplasticity and support healing from chronic illness. In this episode, Gupta explains the basis for his hypothesis and shares an overview of the steps involved in the brain retraining process. A truly fascinating episode, you shan’t be disappointed! *Highlights * • Looking to the brain (2:55) • Gupta’s hypothesis - “we are survival machines” (4:30) • Why we need to address the cause of complaints (15:00) • Honing in on the amygdala and insular (17:00) • Fear extinction (27:00) • Retraining the brain (30:00) • Research results from amygdala and insular retraining (39:00) • Who would benefit from this program? (44:40) • How to sign up (53:20) Useful links and resources: e.g: https://www.guptaprogram.com/