Breathe Easy

Guest: Dr. Alpa Patel, MD. Associate Professor of Pediatrics, The Ohio State College of Medicine. Director, Cardiopulmonary Rehabilitation Program, Nationwide Children's Hospital, Columbus, OH.Host: Dr. Andres Herrera-Camino, MD. Assistant Professor/Clinical Scholar, Department of Child Health, The University of Arizona College of Medicine in Phoenix. Divisions of Pediatric Critical Care and Pulmonary Medicine, Phoenix Children's Hospital, Phoenix, AZ.

Guests:Dr. Rod Rahimi, Instructor in Medicine, Massachusetts General Hospital; Chair of the AII Early Career Working GroupDr. Rachel Scheraga, Assistant Professor of Medicine, Cleveland Clinic; former Chair of the AII Early Career Working GroupDr. Fernando Holguin, Professor of Medicine, University of Colorado; AII Programming Committee ChairDr. Jay Kolls, Professor of Medicine, Tulane University, AII Assembly Chair Host:  Dr. Marc Gauthier, Assistant Professor of Medicine, University of Pittsburgh Medical Center

In this “Breathe Easy Critical Perspective” podcast, Dr. Dominique Pepper interviews Dr. Dharshi Karalapillai. They discuss the trial published in JAMA (September 2020) that investigated the effect of low versus conventional tidal volumes during operative procedures. Dr. Karalapillai is a dual-trained anesthetist and Intensive care physician. He is a Staff Intensivist and a Visiting Anesthetist at Austin Health, Australia.

Contact Information: Ryan Thomas, MD:  @MSUPedsPulmRobert Quinn, PhD:  @Quinn_LabsATS Peds:  @ATSPedsSelected Relevant References: Lindsay Caverly: Caverly LJ et al. Measures of Cystic Fibrosis Airway Microbiota During Periods of Clinical Stability. Ann Am Thorac Soc. 2019 Dec;16(12):1534-1542.Caverly LJ, Zhao J, LiPuma JJ. Cystic fibrosis lung microbiome: Opportunities to reconsider management of airway infection. Pediatr Pulmonol . 2015 Oct;50 Suppl 40:S31-8.Caverly LJ, Huang YJ, Sze MA. Past, Present, and Future Research on the Lung Microbiome in Inflammatory Airway Disease. Chest . 2019 Aug;156(2):376-382.Caverly LJ, LiPuma JJ. Cystic fibrosis respiratory microbiota: unraveling complexity to inform clinical practice. Expert Rev Respir Med. 2018 Oct;12(10):857-865.Carmody et al. Fluctuations in airway bacterial communities associated with clinical states and disease stages in cystic fibrosis. PLoS One. 2018 Mar 9;13(3):e0194060.Robert Quinn: Quinn RA et al. Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome. ISME J. 2016 Jun; 10(6): 1483–1498. Quinn RA et al. A Winogradsky-based culture system shows an association between microbial fermentation and cystic fibrosis exacerbation. The ISME Journal volume 9, pages1024–1038. ISME J. 2015 Mar 17;9(4):1024-38.Quinn RA et al. Metabolomics of pulmonary exacerbations reveals the personalized nature of cystic fibrosis disease. PeerJ. 2016 Aug 11;4:e2174.Raghunashi R et al. High-Resolution Longitudinal Dynamics of the Cystic Fibrosis Sputum Microbiome and Metabolome through Antibiotic Therapy. mSystems. 2020 Jun 23;5(3):e00292-20.Quinn RA et al. Ecological networking of cystic fibrosis lung infections. NPJ Biofilms Microbiomes. 2016 Dec 2;2:4.Other Referenced Works: Muhlebach MS et al. Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children. PLoS Pathog. 2018 Jan 18;14(1):e1006798.Sly PD et al. Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening. Am J Respir Crit Care Med 2009; 180: pp. 146-152JM Flynn et al. Disruption of Cross-Feeding Inhibits Pathogen Growth in the Sputa of Patients with Cystic Fibrosis. Muhlebach MS et al.  Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study. Eur Respir J. 2018 Jul 11;52(1):1800242. mSphere. 2020 Apr 29;5(2):e00343-20.Pittman JE et al. Association of Antibiotics, Airway Microbiome, and Inflammation in Infants with Cystic Fibrosis. Ann Am Thorac Soc. 2017 Oct;14(10):1548-1555.Nelso MT et al. Maintenance tobramycin primarily affects untargeted bacteria in the CF sputum microbiome. Thorax. 2020 Jul 6Cowley SC et al. Pediatric Cystic Fibrosis Sputum Can Be Chemically Dynamic, Anoxic, and Extremely Reduced Due to Hydrogen Sulfide Formation. mBio. 2015 Jul 28;6(4):e00767.Heltshe SL et al. Pseudomonas aeruginosa in cystic fibrosis patients with G551D-CFTR treated with ivacaftor. Clin Infect Dis. 2015 Mar 1;60(5):703-12.Singh SB. Pathogen acquisition in patients with cystic fibrosis receiving ivacaftor or lumacaftor/ivacaftor. Pediatr Pulmonol. 2019 Aug;54(8):1200-1208.Hisert KB et al. Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1617-1628.

Host Lauren Castro, APNGuestsLinda Chlan, RN, PhD Annie Heiderscheit, PhD, MT-BC, LMFTResourcesFeatured articles from Pubmed:Music and six-minute walk-distance- one step at a time: Commentary on "Rhythmic auditory stimulation increases 6-minute walk distance in individuals with COPD: A repeated measures study"Economic Evaluation of a Patient-Directed Music Intervention for ICU Patients Receiving Mechanical Ventilatory SupportEffects of patient-directed music intervention on anxiety and sedative exposure in critically ill patients receiving mechanical ventilatory support: a randomized clinical trial

Guest: Dr. Sarah Train, Pulmonary and Critical Care Medicine Fellow at the Brigham and Women's Hospital and Dr. Jeremy Richards, Assistant Professor of Medicine at the Beth Israel Deaconess Medical CenterHosts: Dr. Stephanie Maximous, Assistant Professor of Medicine at the University of Pittsburgh Medical Center

More Information: ATS COVID-19 Resource Center

Moderators: Kevin Smith, PhD and David Ingram, MDSupplemental Material

Guest: Dr Mona Sarfaty (Executive Director, Medical Society Consortium on Climate and Health, Center for Climate Change Communication, George Mason University)Host: Dr Claire Nolan (PR Assembly Web Director, Harefield Respiratory Research Group, UK)Health Benefits of Air Pollution Reduction

More Information: ATS COVID-19 Resource Center