Scientific Sense ®

Decision Options ® by Gill Eapen: Dr. Julio Guerrero who is CEO and founder of Cambridge Research and Technology L.L.C., which provides consulting services and actionable innovations in engineering and scientific fields at any stage of product development. Industries in which he has focused lately include Energy and Biomedical, with concentration in most domains inside Mechanical, Electronics, and Civil engineering. Hydrogen, electrolyzers, fuel cells in O&G field operation Off grid thermal without PVC or wind, and with rocks only Residential geothermal without deep wells Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1

Scientific Sense ® by Gill Eapen: Prof. Julia Lane is a Professor at the NYU Wagner Graduate School of Public Service. She served in the National AI Research Resources task force and also on the advisory committee on data for evidence building. Her book democratizing our data a manifesto was published in 2020 and she was one of the early guests on this podcast.  Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1

Scientific Sense ® by Gill Eapen: Ayelet Fishbach is Professor of Behavioral Science and Marketing at the University of Chicago Booth School of Business, and the past president of the Society for the Science of Motivation and the International Social Cognition Network (ISCON).   You think failure is hard? So is learning from it Motivating personal growth by seeking discomfort Social exploration: When people deviate from options explored by others. Surprised elaboration: When White men get longer sentences. Can’t wait or won’t wait? The two barriers to patient decisions The structure of intrinsic motivation  Get it Done: Surprising Lessons from the Science of Motivation.    Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1

Scientific Sense ® by Gill Eapen: Prof. Holden Thorp is Editor-in-Chief of Science family of journals. Before he was provost at Washington University where he holds appointments in both chemistry and medicine.  https://www.science.org/doi/10.1126/science.abq8460 It ain’t over ’til it’s over   The Biden administration is sheepishly waving a checkered flag on the pandemic.   h ttps://www.science.org/doi/full/10.1126/science.adf3072 Remember, do no harm? When the advocacy group America’s Frontline Doctors appeared on the steps of the United States Supreme Court in 2020, falsely stating that hydroxychloroquine was a cure for COVID-19, their pronouncement was virally shared by right-wing media and soundly debunked by medical academicians.    https://www.science.org/doi/10.1126/science.adg2577 Hard, not easy Science’s Breakthrough of the Year is the successful launch and deployment of the James Webb Space Telescope (JWST).   https://www.science.org/doi/10.1126/science.abo3934 Science needs affirmative action As science struggles to correct systemic racism in the laboratory and throughout academia in the United States, external forces press on, making it even more difficult to achieve equity on all fronts—including among scientists. The latest example is the decision by the US Supreme Court to hear cases brought against Harvard University and the University of North Carolina (UNC) at Chapel Hill challenging their right to use race as a factor in undergraduate admissions.

Scientific Sense ® by Gill Eapen: Prof. Leah Krubitzer is professor in the Department of Psychology and Center for Neuroscience at the University of California, Davis.   Her current research focuses on the impact of early experience on the cortical phenotype, and she specifically examines the effects of the sensory environment on the development of connections, functional organization and behavior and seeks to understand how culture impacts brain development.    The Combinatorial Creature: Cortical Phenotypes within and across Lifetimes.    Not all cortical expansions are the same: The coevolution of the neocortex and the dorsal thalamus in mammals  Future of the Brain: Essays by the World’s Leading Neuroscientists   Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1

Scientific Sense ® by Gill Eapen: Prof Trey Ideker is Professor of Medicine, Bioengineering and Computer Science at the University of California, San Diego. He directs the National Resource for Network Biology, and the Cancer Cell Map and Psychiatric Cell Map Initiatives.   A multi-scale map of cell structure fusing protein images and interactions. Nature. 2021 Nov 24. doi: 10.1038/s41586-021-04115   “We Might Not Know Half of What’s in Our Cells, New AI Technique Reveals  Interpretation of cancer mutations using a multiscale map of protein systems. Science. 2021   A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.   A protein interaction landscape of breast cancer. Science. 2021 Oct;374(6563):eabf3066  “Studies Delve Deep into the Protein Machinery of Cancer Cells.” NCI (4 Nov 2021) “From COVID to cancer, gene-mapping tool could ‘revolutionize’ treatment“. SF Chronicle (2 Oc  “Moonshot Project Aims to Understand and Beat Cancer Using Protein Maps“. Singularity Hub (5 Oct 2021)  “Looking Beyond DNA to See Cancer with New Clarity,”   Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells. Cancer Cell (2020), https://doi.org/10.1016/j.ccell.2020.09.014. PMID: 33096023. [PDF] [PubMed] Related Press: UCSD Health, AZoLifeSciences, Med India, Health IT Analytics and ScienceDaily.   Quantitative Translation of Dog-to-Human Aging by Conserved Remodeling of the DNA Methylome. Cell Systems. 2020 Aug 26;11(2):176-185.e6. doi: 10.1016/j.cels.2020.06.006. Epub 2020 Jul 2. PMID: 32619550 [PDF] [PubMed] *Cover Article  Related Press: Here’s a better way to convert dog years to human years, scientists say. Science Magazine (15 Nov 2019).  See also: Scientific American, BBC, NPR, Washington Post, Discover Magazine, Smithsonian, New York Post, (and more)   Identifying Epistasis in Cancer Genomes: A Delicate Affair. Cell. 2019 May 30;177(6):1375-1383. doi: 10.1016/j.cell.2019.05.005. Review. PMID: 31150618 [PDF] [PubMed]    Using deep learning to model the hierarchical structure and function of a cell.* Nat Methods. 2018 Mar 5. doi: 10.1038/nmeth.4627. PMID: 29505029 [PDF] [PubMed] [Cover Art] *Cover article   Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1

Scientific Sense ® by Gill Eapen: Alessandro Gavazza is Professor of Economics at the London School of Economics and Research Fellow of the Centre for Economic Policy Research. He is an applied economist, with main interests in industrial organization. His research focuses on the role of frictions in markets.  Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1

The Persistent Effects of Decreasing Labor-Market Discrimination, Do Youth Employment Programs Work? Evidence from the New Deal, The association between educational attainment and longevity using individual-level data from the 1940 census, Discrimination and Racial Disparities in Labor Market Outcomes, and The Incentive Effects of Cash Transfers to the Poor   Scientific Sense ® by Gill Eapen: Adriana Lleras-Muney is a Professor of Economics at UCLA. Her research examines the relationships between socio-economic status and health, with a particular focus on education and income.   Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1

Deep History and the Rhythm of Catastrophe and Merleau-Ponty and the Eco-Literary Imaginary,    Scientific Sense ® by Gill Eapen: Prof. Louise Westling is Professor Emerita of English and Environmental Studies at the University of Oregon. Her research focuses on ecophenomenology and literature, animality, and embodiment in language. A related activity is herding sheep with Australian Kelpies, a good way to learn and develop cross-species communication.   Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1

What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion? Evidence for the Involvement of TNF and NF-kB in Hippocampal Synaptic Plasticity, NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus, Early Growth Response 2 (Egr-2) Expression is Triggered by NF-κB Activation, and Chronic dietary creatine enhances hippocampaldependent spatial memory, bioenergetics, and levels of plasticity-related proteins associated with NF-κB    Scientific Sense ® by Gill Eapen: Prof. Benedict C. Albensi is a Professor and Chair of the Department of Pharmaceutical Sciences and the co-director of the BRAIN Center at Nova SouthEastern University. His research interests include factors involved in ageing, cognition, and Alzheimer's disease (AD), such as nuclear factor kappa B (NF-kB), a mediator of inflammation but also a required molecule for memory.    Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1