Possible
Reid Hoffman
What if, in the future, everything breaks humanity's way? Possible is an award-winning, weekly podcast that sketches out the brightest version of the future—and what it will take to get there. Hosts Reid Hoffman and Aria Finger explore what’s possible with forward-thinking leaders, deep thinkers, and ambitious builders across many fields, such as technology, art, education and healthcare. These conversations center on the ways technology—and, in particular, AI—is shaping the future. In episodes, AI tools such as OpenAI’s GPT-4 and Inflection’s Pi are at work, offering informational asides, prompting guests, or demoing what they can do. Lastly, between guest episodes, Aria interviews her co-host Reid on his latest takes on what’s possible if we use technology—and our collective effort—effectively.
Episodes
Mentioned books
Feb 4, 2026 • 49min
CryptoPunks creators: from art experiment to cultural movement
John Watkinson, co-founder of Larva Labs and digital art/software maker, and Matt Hall, technologist-artist behind CryptoPunks, discuss their 10,000-character experiment that became a cultural movement. They talk about on-chain permanence, decentralization as design, how digital identity found value, museums embracing pixel art, and the tradeoffs of immutable smart contracts.
92 snips
Jan 28, 2026 • 35min
Reid Riffs with Parth Patil on AI-Native Startups (Part 3 of 3)
Parth Patil, an AI specialist building AI-native workflows and tools, shares practical demos and technical examples. He discusses decomposing work into modular pieces, orchestrating fleets of agents in parallel, and coding agents that let small teams tackle big engineering tasks. He also explores automated localization pipelines, voice cloning across languages, and how AI can quietly amplify creativity.
140 snips
Jan 21, 2026 • 40min
Reid Riffs with Parth Patil on Enterprise AI Integration (Part 2 of 3)
In this engaging discussion, AI engineer Parth Patil delves into the practical integration of AI into enterprises. He highlights the concept of 'AI theater,' where organizations buzz about AI without real implementation. Parth emphasizes the importance of language models to streamline communication and reimagine meetings. He discusses how AI can enhance decision-making and transform workflows from task execution to orchestration. By fostering an open mindset, teams can leverage AI's potential, making it a foundational tool for innovation and leadership.
217 snips
Jan 14, 2026 • 45min
Reid Riffs with Parth Patil on Individual AI Mastery (Part 1 of 3)
In this engaging discussion, Parth Patil, an AI engineer known for his innovative workflows and creative tools, shares insights on individual AI mastery. He explores how AI can shift from a mere productivity tool to a meta-tool that enhances daily tasks. Parth dives into role-based and meta-prompting techniques, emphasizing humility in interacting with AI. He advocates for voice as a preferred interface and discusses how to orchestrate fleets of specialized agents, revealing both the potential and pitfalls of using AI in everyday scenarios.
100 snips
Jan 7, 2026 • 1h 19min
Amjad Masad on vibe coding, AI agents, and the end of boilerplate
Amjad Masad, founder and CEO of Replit, shares his journey from teaching himself to code in Jordan to democratizing programming through his platform. He discusses the influence of gaming on product design and champions 'vibe coding' as the future of literacy. The conversation touches on AI's role in enhancing creativity and human agency, arguing for a shift towards computational thinking over syntax mastery. Masad envisions a world where anyone can build using natural language, reshaping societal norms around jobs and entrepreneurial potential.
44 snips
Dec 31, 2025 • 1h 8min
BONUS: Conversations with Coleman: Big Tech, Politics, and Trust in Institutions
In a gripping conversation, Reid Hoffman, entrepreneur and LinkedIn co-founder, tackles the troubling rise of politically motivated prosecutions and the erosion of trust in institutions. He discusses the impact of misinformation on vaccine skepticism and emphasizes the need for platforms to promote truth. Hoffman shares insights on deepfakes, advocating for verification solutions, and examines the philosophical debate surrounding billionaires and inequality. The risks of Trump's authoritarian threats and the politicization within the DOJ are also highlighted, painting a complex picture of today's political landscape.
44 snips
Dec 24, 2025 • 59min
Stephen Colbert on connection, discovery, and human nature
Join comedian and political satirist Stephen Colbert as he explores the transformative nature of live performance and its role in building genuine connections. He delves into the complexities of creativity in the age of AI, questioning whether machines can replicate the richness of human emotion. Colbert discusses the insights from J.R.R. Tolkien that shape his worldview and reflects on the vital imperfections of human interaction. He also shares hopes for the future, from advancements in medicine to deeper explorations of space.
41 snips
Dec 17, 2025 • 32min
The power of AI, from curing cancer to ballot boxes
Siddhartha Mukherjee, a Pulitzer Prize-winning oncologist and the mind behind Manas AI, dives deep into the transformative role of AI in medicine. He highlights breakthroughs in cancer immunotherapy, including engineered T-cells that tackle previously unsolvable cases. The conversation extends to AI's potential in drug discovery, creating a 'molecular oracle' for new treatments. They also explore Silicon Valley's evolving culture, advocating for technology that prioritizes humanity and truth, especially as AI influences public discourse and political opinion.
62 snips
Dec 10, 2025 • 18min
The AI energy war is here
Explore why compute is now considered the new oil fueling the cognitive industrial revolution. Discover how data centers are driving wage growth for blue-collar workers and reshaping local economies. Address common myths about their energy costs and learn how China's aggressive energy expansion poses a competitive threat. Hear calls for a comprehensive U.S. energy strategy that includes nuclear, solar, and wind to secure jobs and intellectual property. Understand the importance of keeping AI infrastructure on American soil for national security and prosperity.
134 snips
Dec 3, 2025 • 45min
R.I.P. Computer Keyboard (1964 – 2025)
Tanay Kothari, Founder and CEO of Wispr Flow, shares insights on a future where voice replaces keyboards as the primary interface. As a child, Tanay built one of the first voice assistants, paving the way for his innovative AI product used by many Fortune 500 companies today. He discusses how voice enhances accessibility, emotional connection, and user engagement while showcasing a thrilling live demo comparing voice typing to traditional typing. Tanay envisions a world where technology encourages human presence and interaction, transforming how we communicate.
