Possible The power of AI, from curing cancer to ballot boxes
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Dec 17, 2025 
Siddhartha Mukherjee, a Pulitzer Prize-winning oncologist and the mind behind Manas AI, dives deep into the transformative role of AI in medicine. He highlights breakthroughs in cancer immunotherapy, including engineered T-cells that tackle previously unsolvable cases. The conversation extends to AI's potential in drug discovery, creating a 'molecular oracle' for new treatments. They also explore Silicon Valley's evolving culture, advocating for technology that prioritizes humanity and truth, especially as AI influences public discourse and political opinion.
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Book Born From A Trainee's Journal
- Siddhartha Mukherjee began Emperor of All Maladies as a personal journal while training in oncology.
- A patient's question, "How did we get here?", sparked the book's creation and long expansion.
Four Domains Reshape Cancer Understanding
- Cancer progress clusters into prevention, early detection, immunotherapy, and a new physiology lens.
- These four arenas redefine how we imagine and treat cancer today.
Nonmutational Carcinogens Matter
- New carcinogens may drive cancer by altering tissue environments rather than causing mutations.
- Air pollution and possibly 'forever chemicals' exemplify this emerging class.