Applied Physics Laboratory engineer (and Andy's old college roommate) Dipak Srinivasan returns to the podcast to talk about his work on the Mercury MESSENGER mission, the Pluto New Horizons flyby (that'll also soon be visiting Kuiper belt object 2014 MU69), and most importantly, the upcoming Parker Solar Probe and a mission to Jupiter's moon Europa, the most likely place in our solar system to find extraterrestrial life.

Comedy's Kara Klenk (@karaklenk) joins Matt and Andy to talk about why Trump isn't good for comedy, bad forensics, hungry thinky worms, penis biting, bleach enemas to cure autism, slugs, Canaanites who just won’t die and The Goldwater Rule.

Comedian Heather Thomson (@CasualVelvet) joins Andy and Matt to discuss early email addresses, Woodboys, laws of mathematics that don’t apply in Australia, why chimps are pussies, how humans can out-jog horses, antibiotic lies, reversing brain damage with oxygen, Moon water, and the avocado hand epidemic.

Comedian Jim Hegarty (@jimhegarty) joins Matt and Andy to talk about good and bad TV, the Up Series, fireworks contamination, dog domestication, junk DNA, the crazy fly book price, Brewster’s Millions rules, egg shapes and egg refrigeration.

Jason Reich (@jasonmreich), the head writer of The Jim Jefferies Show, joins Matt and Andy to discuss eating street apples and syringes, Vegas strategy, an HIV cure, why job interviews are bullshit, old dads with geeky sons follow-up, gonorrhea vaccines, vaquitas, fireworks technology, Alex Jones before and (redder) after and what Goop has in common with Infowars.

Cognitive behavior therapist Dr. Jane Gregory joins Matt and Andy to talk about her work and how she helps people suffering from anxiety, post-traumatic stress disorder, obsessive-compulsive disorder and more, along with her fantastic blog Cognitive Behave Yourself in which she puts her money where her mouth is and subjects herself to some of the techniques that she asks her patients to use.

Comedy's Maggie Maye (@Maggiemayehaha) joins Matt and Andy to discuss first TV bed-sharers, rival Amarillo songs, coconut oil, why it's too hot to fly, heat-based reptile sex swapping, older dads and geeky sons, neutron decay, lying chatbots and wobbling suitcases.

Writer and comedic actor Lucas Kavner (@lucaskavner) joins Andy and Matt to talk about rebooted shows, reporting on robots, dog and wolf sharing, how breakfast affects benevolence, Einstein's impossible experiment finally performed, gut bacteria and dinosaur sex.

Comedian Curtis Cook (@Curtis_Cook) writes with Matt on The Jim Jefferies Show, and he sits down to discuss fancy premiere parties and imposter syndrome, catapult-making, how depressing the first Peanuts comic strip is, how AI will beat humans at everything by 2060, Moravec’s paradox, dino feathers and scales, getting re-upped on your vaccines, rust getting unfairly blamed for tetanus and parasitic worm healing.

Renee Colvert (@ReneeColvert) of the hit podcast Can I Pet Your Dog? joins Matt and Andy to discuss Paris disagreements, dog podcasting, universal healthcare, Savage/Soundgarden, Australian healthcare, another LIGO victory, Janna Levin's book, the Parker Solar Probe, the monkey mafia who steal your stuff and sell it back to you for a cracker, measuring sheep pain, and hand-washing rules.