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This week on the SuperAge podcast, we dive into the world of integrative and preventive medicine with Dr. Chris Renna. Dr. Renna, with a career spanning over three decades, shares his unique perspective on achieving optimal health and longevity. From discussing the nuances of detoxification and the role of the microbiome to exploring the future of biotech and AI in medicine, Dr. Renna provides a comprehensive look at modern healthcare techniques. He emphasizes the importance of individualized treatment plans and the integration of various modalities like nutrition, sleep, and exercise for overall well-being. The conversation challenges conventional medical thinking and a road map into the future of personal health management.What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)Thanks to our sponsors:InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. Key Moments“The Goldilocks concept is really the goal, but it is really complicated and highly individualized, meaning balance is quite subjective.”“We're on the verge of developing generative A.I. Now we're considering both the risks and benefits of sentience, and I think that the way our brain works, we are naturally drawn to the risk before we're drawn to the opportunity. And I think that works, you know, like that's kept us here and that's brought us forward in our technologies.”“If God had a complete understanding of every physiologic system and all of its implications and interactions, what would God recommend we have for supper? Generative A.I. holds that potential. It would only inform us. So I think that, you know, the future is amazingly bright.”Connect with Dr. Chris RennaLifeSpanContactBookSay hi to the AGEIST team!

This week, we speak with Karl Pfleger, PhD who, after studying Machine Learning at Stanford and working a successful tech career, now does all he can to support longevity research and biotech. Karl discusses the inadequacies of traditional healthcare in addressing the root causes of aging and shares insights on groundbreaking research that can slow down or even reverse aging processes. He emphasizes the significant impact of lifestyle choices on longevity and previews promising future therapies, including stem cell treatments and mitochondrial health interventions.What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)Thanks to our sponsors:InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. AmeriCorps Seniors — Get involved in your community through AmeriCorps Seniors’ volunteer opportunities and change your life. Go to AmeriCorps.gov/YourMoment Key Moments“So the traditional health care and medical practice in our country, in the US and most of the world concerns really considering everyone to be baseline healthy until they get sick to a level where they're very sick and they cross some kind of a threshold for diagnosis of having an actual disease. So even though we call it health care, a lot of people kind of pejoratively describe it as sick care.”“In short-lived species you can extend lifespans manyfold. One single gene mutation in worms can extend their lifespans by 10X, for example. And even in mice, we have interventions now that can extend their lifespans by 30% or 40% sometimes. And many of these interventions work across multiple species. So we believe they’re likely to work for people as well."“I wanted them to realize how big [the longevity field] had gotten so that they wouldn't delay getting into it with more serious amounts of money. They didn't realize that they were two years behind given how fast it was growing.”Connect with Karl PflegerXAgingBiotech.infoLinkedInSay hi to the AGEIST team!

In this week's SuperAge podcast, we delve into Denise Kirtley's vital midlife transformation from overweight and pre-diabetic, to empowered and strong. Denise shares her journey of overcoming common misconceptions about fitness and weight loss in midlife, emphasizing the importance of a tailored approach to nutrition and exercise. She discusses how setting personal goals and dreams played a crucial role in moving beyond societal expectations. Denise also highlights the oft-overlooked impact of physical strength on mental well-being and confidence, inspiring others in similar life stages. The conversation is a testament to the power of self-care and the potential for transformation at any age.What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)Thanks to our sponsors:DIVI – take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. Key Moments“Aesthetics was a goal of mine, but more importantly, as I had gained weight, my health declined. And what did that look like? I became pre-diabetic. I started having joint pain in my knees specifically. Unfortunately, I have 50 stairs from the ground level to my front door. I had to go up and down the stairs every day.”“Before, I wasn't even very good about getting my blood work done regularly. Now I do it twice a year. That's a huge part of my health regimen. I take supplements based on what my blood work says. And I think you have to be intentional like this if you want to age strong and healthy and vibrant.”“They see me muscular and in a bikini. And at 53, they say ‘that's not what someone should be doing.’ I do feel there is some of this ageism in those comments. I really do feel that. I also think we're very focused on: ‘well, you were fine before. Why did you do that?' – I wasn't fine. Right. I was pre-diabetic. I woke up exhausted. I felt like crap most days, right? My quality of life was poor. So I think we need to get beyond what we see and realize that this was a health journey.”Connect with DeniseRebellion BodyContactInstagramSay hi to the AGEIST team!

Our first guest of 2024 is Dr. Darshan Shah, a surgeon, longevity expert, and founder of Next Health. In their conversion, David and Dr. Shah take a snapshot of today’s ever-changing health optimization and longevity landscape.The two discuss new diagnostic tools like executive physicals and AI-enabled heart scans, highlighting the power of early detection in combating conditions like Alzheimer’s, heart disease, and cancer. David also takes the opportunity to learn all about up-and-coming treatments like gene therapy from an expert. Dr. Shah also shares his personal journey from surgery to functional medicine, emphasizing the importance of looking beyond traditional Western healthcare to prevent chronic diseases. What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)Thanks to our sponsors:InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Science Research Wellness — improve your cellular health. Listeners receive 20% off all products with code AGEIST20 at SRW.co.LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. Key Moments“I think there's a lot going on in the world of longevity that unfortunately the FDA is trying to block. But you know, the research continues to go on in other countries and it will continue to flourish and we will be able to do a lot of these things here at some point, whether it be in the United States or outside.”“I always tell people that we have a few different goals in mind. Our first goal is to optimize along the most common things we need to make sure your nutrition, your exercise and your sleep is perfect, right? And so as close to perfect as we can get it.”“If Steve Jobs were alive today, and he had an executive physical, he would have been saved from pancreatic cancer."“I always tell my patients, you need to know what your hemoglobin A1C level is. I should ask you, and you should be able to tell me what it is.”Connect with Dr. ShahWebsiteNext HealthMaking the Cut: 10 Things You Should Consider Before Having Plastic SurgeryInstagramSay hi to the AGEIST team!

This week, we discuss the importance of setting realistic and sustainable goals. If we can form positive, long-term habits rather than resorting to extreme, short-term “resolutions,” we can get more healthy every day. Reflecting on previous goals, David shares personal anecdotes and lessons learned. Why not take a gradual approach to fitness and nutrition that aligns with one's lifestyle and capabilities? The episode is a blend of practical advice and motivational insights aimed at fostering a healthier, more self-aware approach to personal growth and well-being.Thank you to our sponsors: LMNT – our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. InsideTracker — the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. Key Moments“When people think about goals for the new year, they often initially think about things like diets and exercise, fitness, these sort of things. What I have seen, I've seen this multiple times. I have engaged in this myself and I can tell you it does not work.”“We're looking to establish habits, habits that we can keep for a long period of time. Extreme diets are not a habit. They're sort of a short term occasion, and just a recipe for failure. We want to slightly modify what we're doing so that we can achieve it, so we can pat ourselves on the back and say “great job, reevaluate in three months.”“So this is an achievable target and it's measurable, which is really key about this.”Say hi to the AGEIST team!

This week, we host James Whittaker, entrepreneur and bestselling author of Think and Grow Rich: The Legacy and Andrew Carnegie’s Mental Dynamite. James turned his struggle with anxiety into a journey of self-discovery and success. James highlights his 'WIN method' - Wonder, Intent, Nurture - as a framework for purposeful living and defining success on a personal basis. Emphasizing self-awareness and resilience, James aligns perfectly with SuperAge’s vision of meaningful growth.What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)Thanks to our sponsors:InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. Key Moments“It's better to be green and growing than ripe and rotting. Like just because you've had a few wins and adventures in your past doesn't mean that you need to hang up your hat.”“The longer we're in an environment where we're by ourselves, that's where this stuff gets really, really dangerous because we simply lose track of what's possible. So we retreat to autopilot, which works on the condition that you're very intentional with it. If you're not intentional and you don't have a process of getting around really high-level thinkers on a consistent basis, then you need to be conscious that that autopilot is going to eventually work against you”“It's really important to think about what season of life you're in and what is the metric for you to determine whether or not you're making the right progress. And sometimes just simply being on the right journey is enough. It doesn't matter about some of these other things that may or may not have manifested, just simply being on the right path and being aware of what's around you and putting one foot in front of the other, knowing that the universe is working for you.”Connect with JamesWebsitePodcastBooksGet in TouchSay hi to the AGEIST team!

In this week’s episode of SuperAge, Dr. David Spiegel, who, after receiving a PhD in medicine from Harvard, went on to become a renowned expert in hypnosis, dissociative disorder, PTSD, as well as a Stanford professor. He has also authored many books over the course of his 40-year career, including Living Beyond Limits: A New Hope and Help For Facing Life-Threatening Illness. In our conversation, Dr. Spiegel shares his insights on harnessing the power of the mind for healing and wellness. Drawing from experience, Dr. Spiegel discusses the significant impact of hypnosis in managing pain, stress, and anxiety, especially in cancer patients. He illustrates how self-hypnosis can be a vital tool for emotional and physical wellbeing and provides fascinating stories about its effectiveness. This episode offers a unique perspective on research-backed alternative healing methods, emphasizing the untapped potential of the human mind in health and recovery.What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)Thanks to our sponsors:DIVI – take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Science Research Wellness — improve your cellular health. Listeners receive 20% off all products with code AGEIST20 at SRW.co.Key Moments“We started out helping people to stop smoking and we found that one out of five people just stopped smoking using the [Reveri] app right away. So that's about as good as I get when people are sitting in my office and I'm doing it. And it's about as good as you get using varenicline or bupropion or nicotine patches as an alternative.”“They learned to control their pain with self-hypnosis so that a new pain in their chest didn't automatically mean to them that their disease was progressing. It meant they needed to do something to control the pain. And they did. So they had half the pain. And in our original study that we published in The Lancet, we found that the women randomized to work groups actually live longer than the control patients by an average of a year and a half.”“We found actually that people with breast cancer who were inefficient sleepers, who had trouble getting to sleep or staying asleep, actually also had shorter survival. But the other way around is that good sleepers live longer. It was having a long period of good 7 hours of consistent sleep at night, predicted with fewer disruptions, predicted longer survival with breast cancer.”“After a deep inhale, a slow exhale is important. And part of why it is is, you know, we're used to saying, you know, if you're anxious or tense, take a deep breath. Well, actually, the inhale actually tends to increase sympathetic activity because it reduces venous return or blood to the heart. If you think about it, you're lowering pressure in the chest.”Connect with Dr. SpiegelReveri App: Support someone who supports you this holiday season. To gift a 1 year subscription of Reveri to someone you care about, simply head over to Say hi to the AGEIST team!

In this show, we learn that incredibly high powered AI is now being used in human nutraceutical research, specially targeting the 9 hallmarks of aging. Our guest Greg Macpherson, CEO of SRW Labs in New Zealand, joins us this week to share all about how automated labs are making unprecedented progress in identifying and creating compounds that may solve human longevity. By automating many of the tedious testing and refinement processes, AI labs are able to work with extreme efficiency, which translates to bringing meaningful longevity products to the public with extraordinary speed. We are very excited to learn about this from Greg, and to hear that we could be expecting to see some new targeted products hitting the market by summer 2024. What kind of SuperAger are you? Take the SuperAge Quiz and find out! (visit: ageist.com/quiz)Don’t forget to watch this week’s episode of “Since You Asked” a new Q&A show from AGEIST. Thanks to our sponsors:InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist.LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.Key Moments“So we are going to get to a stage where we get to have a DNA test before we start taking medicine and you know there may be 10 drugs on the shelf that are appropriate for whatever condition that's being treated and they'll select the one that's best for you. But also they'll be able to look at it and go, okay, look, there's a high chance, given your genetic makeup, that these are going to be a problem.”“There are animals out there that live for 200 years like the bowhead whale. They are mammals just like us, so there's no reason that we can't learn from whatever genetic hacks that they've got which mean that they live longer. And then, of course, the Greenland shark lives for 500 years. So these are animals. We can learn from them, and once we do, then all bets are off as to what kind of longevity we're going to see.“Of course it's not the longevity that we think of today. We're going to be talking about bodies aged 30 to 40 and having those bodies for 200 years, which is a little outside a frame of reference right now. But future humans are going to go ‘golly, those poor people back then who only got to live for 80 years and only 40 years in good health.’”“In 3-5 years, there will be a product to slow or stop the aging clock”“You know, unfortunately, sugar is cheap and it's tasty and it's nice and we all love it. So there's just a huge industry around it, but it's not serving us well, and now we understand that, just like we went through taxing tobacco, maybe we've got to do the same just to nudge the population away from it and educate people how bad it is for us.”Connect with GregProfile PieceSay hi to the AGEIST team!

We are very excited to have sports and performance psychologist Dr. Lauren Loberg on the show this week to ruminate on the intersection of everyday life and this idea of a “performance mindset.” Everyone wants to do their best, and using insights from working with the world’s top athletes (think: NFL stars and pro skiers like Mikaela Shiffrin), Dr. Loberg shares her tips on how we can implement high performance mental strategies into our daily lives. Together, we discuss anxiety, flow state, and the value of mental preparedness. What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)Don’t forget to watch this week’s episode of “Since You Asked” a new Q&A show from AGEISTThanks to our sponsors:InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.DIVI – Take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.Key Moments“If someone comes to you and says I want to be fit this summer, what does that mean? What exactly does that mean? Or ‘I want to be more present.’ Well, what does that mean for you? What does that look like? Like, what's the action? Because when people provide us with these really arbitrary things and sometimes they do, they can keep judging themselves on it because there's no measurement to it. Does that make sense?”“I think that everyone can be mentally tough, but it's also a thing that takes time. Remember that some of the things you struggle with mentally, might stem from a pattern that you've had for 50 years. Putting this in the context of sports, if you tried to change your golf swing or basketball shot after 50 years of playing, would you be able to fix it in five tries? No. The same goes for mental toughness.”“You can kind of learn how to embrace fear, the fear of when it becomes paralyzing. That's the part that you have to talk through.”Connect with LaurenPyramid PerformanceAbout LaurenContactSay hi to the AGEIST team!

Is it possible to build muscle without lifting weights? Can we tone our facial muscles? Is it possible to improve our cardiovascular system with almost no effort? Today, we sit down with former USA swim coach and Kaatsu CEO Steven Munatones. He tells us all about his decades-long journey of discovery and tutelage under Dr. Yoshiaki Sato in Tokyo, wherein he studied the myriad benefits of Japanese Kaatsu bands and developed a plan to introduce this technology to the world. Huge amounts of research out of Japan are showing that one can maintain strength and vitality as they age, improve overall vascular function, rehabilitate injuries all with zero risk of injury.What kind of SuperAger are you? Check the SuperAge Quiz and find out! (visit: ageist.com/quiz)Thanks to our sponsors:Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Key Moments“Why would someone [restrict blood flow]? They do it for a variety of reasons, and there's a lot of literature out there by researchers, scientists, physicians, and physical therapists, and you want to do this mostly to build muscle. Building muscle helps if you're injured, maybe you had a surgery on your knee, maybe you broke your arm. It helps reduce atrophy. And so part of the recovery process is rebuilding that muscle loss. When you use BFR, you actually reduce the amount of muscle atrophy that you get, so your body will heal itself and then you go through a shorter recovery period because you're not losing as much muscle mass.”“Fundamentally, what's happening is a bit of hypoxia or lack of oxygen in the muscle. If you do movement as simple as bicep curls. It could be stretching, it can be walking, whatever you want to do that leads to that uncomfortable feeling you have when you work out. That lactate sends a signal through your central nervous system up to your brain. And then the brain thinks that you are doing something very vigorous, something very intense. And when the brain receives that signal again, the brain does not know if you're lifting heavy weight or you're just doing BFR. So it reacts as it naturally does and produces growth hormones amongst other metabolites, which flow through our vascular system and promote muscle growth”“The Japanese found that when you engorged the limbs and blood and you do slight movement, this is the most effective way to trigger those signals up to the brain and then release a variety of hormones.”Connect with StevenKaatsuLinkedInBook: Open Water SwimmingSay hi to the AGEIST team!