What are the actions we can take to maintain our long-term brain health? This week, we discuss this and more with Dr. Marc Milstein, author of The Age-Proof Brain. It turns out that even small behavioral changes, such as eating less processed foods and regularly challenging yourself with activities like playing an instrument will support overall brain fitness and neuroplasticity. Furthermore, Dr. Marc also breaks down the surprising link between gut and brain health. What kind of SuperAger are you? Take our quiz today and find out! Visit: ageist.com/quizThank you to our sponsors: Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST.Key Moments: “Anything that is processed is likely to feed bad bacteria. These bacteria have been around much longer than us, and so the things that they like to eat are the things that were around much longer than us, long before we got here, and the bad bacteria tend to feed on the things that we created.”“There's definitely foods that are great for brain health, but it's really about variety and we really have evidence that it's a synergistic relationship. It's not one food item that is just like this brain-boosting magic food. It's how the foods work together and that's why we believe that supplements can be beneficial, but they're not in many cases as beneficial as dietary changes, because what's in the food works together with other nutrients.”“So what we see is that it's not about this stress-free lifestyle. Our brain is like a car, I like to say, and if you don't drive it, it falls apart, and if you over drive it, it falls apart. Stress is a burst of cortisol. Say I want to get something done. There's a challenge, I want to tackle something. All those moments of stress are actually good for our brain because they release cortisol and there's a part of our brain called the hippocampus which is really important for memory, and a squirt of cortisol in a moment of stress actually helps the hippocampus stay strong.”Get in Touch with Dr. MarcThe Age-Proof BrainWebsiteContactSay hi to the AGEIST team!

This week, we chat with Dr. Rich Joseph, the Chief Medical Officer at Restore Hyper Wellness, founder of vim Medicine, and co-founder of Vital CxNs. David made ample use of the Restore facilities during his recovery from knee surgery, and we like how their business helps to make treatments like hyperbaric oxygen therapy, red light therapy, IV drips, and others accessible to the public. During our conversation, Rich shares his view on the literature supporting up-and-coming therapy treatments, the importance of challenging oneself at any age, biomarkers, and his nonprofit work with underserved populations in Boston. What kind of SuperAger are you? Take our quiz today and find out! Visit: ageist.com/quizThank you to our sponsors: DIVI – Take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout.InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. “My whole background is walking this fine line between the traditional medical system and the wellness industry. I was a personal trainer for a long time and that was my first foray into health and wellness before becoming a doctor. Now I help bridge the gap between these two sides. I think we have to be humble, the more I learn, the less I know about this stuff. Human health and our biology is very complicated, and yet there’s unfortunately still this imperative to like, make claims and to be bold in order to get people's attention.”“This stuff is nuanced and we hope that people who really take their health seriously also have the responsibility of helping to advance the data and dig into the science.”“How do you push the body into stress right in a way that's adaptive for the body? And that's what cold therapy does, it's what heat therapy does. This is sort of “perturbing” our homeostasis so that the body becomes more adaptive over time, and is able to better regulate itself.”“Entropy is working on us all the time and so you have to push back against that and that's uncomfortable. That means welcoming and inviting discomfort into your life and to your day and that, to your point, is sort of against everything that we're sold right now and what we're taught to believe is best.”Get in Touch with Dr. JosephRestore Hyper Wellnessvim Performance MedicineVital CxNsSay hi to the AGEIST team!

This week, we are joined by Alan Reznik, MD.MBA FAAOS, an extremely accomplished orthopedic surgeon specializing in sports medicine who literally wrote the book on knee and shoulder health. Pulling from his work: The Knee and Shoulder Handbook, Dr. Reznik shares his expertise surrounding joint surgery, treatment protocols, long-term care, and more with us– breaking complex concepts down to make them accessible for all of us. For David, this was a great opportunity to get more insight into a surgeon’s thought process and key tips to help speed up his recovery What kind of SuperAger are you? Take our quiz today and find out!Thank you to our sponsors: Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% of your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. DIVI – Take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout. Ned Mellö Magnesium — essential supplement to improve sleep, reduce stress, increase energy, and more. Use code “AGEIST” for 15% off at helloned.com/AGEISTKey Moments“The knee is very smart. It does two things when it's mad, it makes fluid, or it hurts, or both. In fact, all of your joints are always making a little bit of fluid. When there’s a lot of fluid in the knee, something's typically wrong. That's a tip, if my knees are very swollen, something is off.”“I could take a plug, a round plug of cartilage from someplace else in your knee that you need less and move it to a place where you need it more, just like a hair transplant."“Once you put a metal plate and a plastic liner on the bone, it will wear at a certain rate. Now the newer materials are very, very good and they wear very slowly. The older materials wore much faster. If you don't have a super active lifestyle, you're not a marathon runner and you put it in, it could be good for 20 or 25 years.”Connect with Dr. ReznikThe Knee and Shoulder HandbookConnecticut Orthopedics PageIntro VideoSay hi to the AGEIST team!

This week, David breaks down the ins and outs of his recent knee surgery–from dealing with insurance, to what to ask your surgeon, to the best strategies for choosing a physical therapist. Today, at 7 weeks post-op, he has almost fully returned to physical activity with the help of intensive physical therapy, regular hyperbaric oxygen therapy sessions, a clean diet, and more. Listen in to hear about how recovery modalities align with protein intake, catabolic vs metabolic states, Katsu therapy, vitamin D, along with additional top-level insights. Thank you to our sponsors: LMNT – our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. InsideTracker — the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.SRW Labs – Science Research Wellness — improve your cellular health. Listeners receive 20% off all products with code AGEIST20 at SRW.co. Key Moments“He said first order of business, we want to reduce your time in the catabolic state as much as we can, and try to keep you anabolic if possible. How do we do that? Clean diet.”“He says to me this is perceived instability. So your brain thinks the knee is unstable because you have this irritation in your meniscus. But your knee is stable.”“So they reduce the recovery time by 50%. I am not an elite athlete. However, this “cutting down recovery time” sounded really good and so I had maybe an hour-long conversation with Scott about what to do.”Say hi to the AGEIST team!

Is chronic pain just a function of our brains? If so, how do we change our perception of pain? Today, we speak with licensed clinical psychiatrist and pain researcher Dr. Afton Hasset. Throughout her career, Afton has delved into the connections between the brain, chronic pain, physical activity, and emotion. She remains at the forefront of her field, and in our conversation she shares several of her favorite takeaways from her most recent book with us. Those of us intimately familiar with chronic pain know just how severely it can impact quality of life and happiness. With that in mind, join us to learn new, game-changing pain management strategies and therapies.  What kind of SuperAger are you? Take our quiz today and find out!Visit ageist.com/quiz – Dr. Afton is a Fox!Thank you to our sponsors: Ned Mellö Magnesium — essential supplement to improve sleep, reduce stress, increase energy, and more. Use code “AGEIST” for 15% off at helloned.com/AGEISTInsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. Key Moments“A little bit of pain is proper. What happens, though, is pain can change from being something like a stimulus response, meaning that you burn your finger and you experience pain. It can turn into something that's not just pain experienced by a burning finger and the brain, sometimes brain actually creates the experience of pain.”“What we see in chronic pain is that the default mode network is talking way too much to another network called the salience network, which is a network that says, hey, pay attention, this is really something big, watch out. And so these two networks are over connected. And so what we look for sometimes in interventions is does the treatment actually start disentangling these two networks?”“So when we define pain, pain is a sensory, it's an emotional and it's a cognitive, for it's a thought derived process. Pain exists because there is this awareness of it. So when people are anesthetized, you don't feel pain.”About Dr. Afton Hasset:Chronic Pain Reset: 30 Days of Activities, Practices, and Skills to Help You ThriveLinkedInBioSay hi to the AGEIST team!

This week, we welcome Elli Kaplan, co-founder of Neurotrack onto the show. Her company is dedicated to the detection and management of cognitive health. Elli and I chat all about the difference between cognition and IQ exams, highlighting the importance of tests like hers in identifying temporary or long-term cognitive changes ranging from overmedication to age-related mental decline. Bonus: we kick the episode off with AGEIST’s infamous Tinder origin story. What kind of SuperAger are you? Take our quiz today and find out!visit: ageist.com/quizThank you to our sponsors: DIVI – Take back control of your hair and scalp health, and do it with Divi's clean, science-backed ingredients. Listeners get 20% off your first Divi order at diviofficial.com/AGEIST or enter code "AGEIST" at checkout. InsideTracker – the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.LMNT – our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. Key Moments“This is not an IQ test, this is a cognitive function test and everybody should want to understand how their brain is functioning and if there are issues that you could then fix–and that may be. As you point out, it may be that someone is on too many medications that are conflicting with each other. It may also be that they are eating fried food seven days a week, are not sleeping, and never exercise.”“You know, historically we haven't had good drugs for, or even good supplements, from a treatment perspective, for cognitive issues. I think that is also starting to change, at least on the lifestyle side. We know that there's a tremendous number of things that you can do to help your brain function.”Get in Touch with Elli Kaplan:NeurotrackLinkedInSay hi to the AGEIST team!

Today we have Phd professor and researcher Michael Leon on the show alongside perfume entrepreneur and founder of Scents of Wood, Fabrice Croisé. In July, Prof Leon published a study which identified a link between olfactory stimulation and memory improvement. Participants in the enriched group’s memories improved by 226%. Michael also discusses how regular exposure to varied scents (think 40 per day) can actually combat the effects of dementia. Join us to learn about this fascinating connection and what you can do to take advantage of this new knowledge. Thank you to our sponsors: Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. InsideTracker — the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Ned Mellö Magnesium — essential supplement to improve sleep, reduce stress, increase energy, and more. Use code “AGEIST” for 15% off at helloned.com/AGEISTKey Moments“We gave humans different odors on a regular basis, and over the course of six months, they too had a massive improvement in their memory 226% better than a similar group of older adults who didn't get this kind of olfactory enrichment”“When you look at sommeliers and perfumers, the memory parts of their brains have expanded significantly. So it's not just that they're experiencing a nice odor, it's that it's actually changing the memory centers of their brain.” “I'm fascinated. I mean I've never, of the many, many, many things that I've heard about about smelling and fragrances and scent over the past 30 years of my career, I've never heard this and it's obviously not the angle that we usually take when we create a fragrance, but it is incredibly fascinating.”Get in Touch with Dr. Michael Leon:Memory Airmleon@uci.eduMichael’s StudyGet in Touch with Fabrice CroiséScents of WoodInstagramSay hi to the AGEIST team!

We are back this week with Dr. Kelly Stankiewicz, our favorite Dermatologist. Dr. Kelly is at the forefront of her field, specializing in laser skin treatments that combat the effects of aging and can even create a youthful glow–if that is your jam. In addition to discussing the latest and greatest in dermatology, we also break down the four core pillars of a sound skincare routine: cleanse, exfoliate, nourish, and protect. Lastly, I ask Dr. Kelly to give us some context around Jimmy Buffett’s tragic passing in terms of the skin cancer that he battled and what we can all do to protect ourselves. Want personalized SuperAger tips? Check out the all-new SuperAge Quiz!Thank you to our sponsors: Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% off your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. InsideTracker — the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Get in touch with Dr. KellyWebsiteContactKey Moments:“What's important is that you're hitting all four of the categories: sunscreens, antioxidants, exfoliants, and cleansers.”“So people, when they hear that someone has died of skin cancer they get very concerned because skin cancer is quite common. The type that Jimmy Buffett had is very, very rare. So all of my patients who've had multiple basal cell carcinomas and squamous cell carcinomas, which don't typically metastasize, are, you know, kind of up in arms because they don't really understand the difference.”“When you're doing fractional resurfacing, you're decreasing your risk for skin cancer probably (or at least according to this one study) by about two times or maybe a little bit more.” Say hi to the AGEIST team!

Dr. Scott Sherr has been a frequent guest and audience favorite with his information-dense guest appearances on The SuperAge Show. This week we speak about new information on some of the brain chemical influences on depression, sleep, and anxiety- specifically the overlooked neurotransmitter GABA. We review the symptoms of GABA dysregulation and the methods for correcting it. Dr Sherr is a clinician, meaning he sees patients and comes at the issues from a more nuanced point of view than pure researchers sometimes do. In the middle of the episode, Dr Scott brings up a surprisingly simple zero risk trick to increase sleep effectiveness. Toward the end of the conversation, David asks about how to increase concentration and focus, and we get into the practical usage of nicotine, methyl blue, and low-dose psychedelics.Additionally, don’t forget to check out the all-new SuperAge Quiz!Thank you to our sponsors: SRW Labs – Science Research Wellness — improve your cellular health. Listeners receive 20% off all products with code AGEIST20 at SRW.co. InsideTracker — the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.Ned Mellö Magnesium — essential supplement to improve sleep, reduce stress, increase energy, and more. Use code “AGEIST” for 15% off at helloned.com/AGEISTKey Moments“So when I do analysis with patients, I'm usually looking at a gamut of labs and what I found over the last several years is that GABA is a big problem, and it's not GABA itself that you're typically looking at, but you're actually looking at some of the amino acids and some of the cofactors that are typically deficient in these kinds of patients that are having symptoms like that are very much correlated with GABA deficiency, and some of those are symptoms that all of us have gone through in our life. From a mental health perspective, we know GABA deficiency is associated with anxiety, with fear, with depression, with short temper, with phobias, with impulsiveness, with disorganization, and addiction.”“The problem with GABA as a supplement is that it's a very big molecule and it doesn't cross the blood brain barrier very easily at all. There are only a couple of different ways to get GABA through. One of them is using something called nicotinoyl GABA or vitamin B3 attached to a GABA”“Cava is a GABA agonist so it helps increase the amount of GABA that binds. It doesn't bind to that GABA site itself, it binds to a separate site a little further away, but it helps with increasing the amount of GABA that's going to bind and you're going to have that feeling of feeling like you've had a couple beers, kind of thing. But the nice thing about cava is it doesn't bind with the same affinity and it also binds to other receptors that help increase wakefulness.”“The first part of this conversation is that nicotine is a fantastic cognitive enhancer. It's very short acting. It's about one to two hours and if you don't smoke it or vape it, keep it very low, and dose less than four milligrams a day. The chance of addiction is minutely small, minuscule. So it's very, very powerful and very quick, and so for people that are looking to feel more of a cognitive edge. They can actually just have some nicotine on its own and it will do that.“Connect with Dr. SherrInstagramHBOTSay hi to the AGEIST team!

This week, we dive in with Dr. Mike Wagner, a Stanford-trained anesthesiologist, to examine the balance between longevity and health practices. Dr. Wagner provides insight into the vast and evolving landscape of health, blending the science with his personal and practical commitment to healthspan, as we explore the intersection of medicine and age. Dr. Wagner shares his perspective on living the most enjoyable and healthy life. Thank you to our sponsors: Timeline Nutrition — our favorite supplement for cell support and mitochondrial function. Listeners receive 10% of your first order of Mitopure with code AGEIST at TimelineNutrition.com/ageist. InsideTracker — the dashboard to your Inner Health. Listeners get 20% off on all products at InsideTracker.com/AGEIST.LMNT Electrolytes — our favorite electrolytes for optimal hydration. Listeners receive a free 8-serving sample pack with their purchase at DrinkLMNT.com/AGEIST. Key Moments:“The best drug you can have is exercise, and so I try to stay fit with both aerobic and strength resistance training because I think both are important. You know, as you get older, one of the major causes of death is falling, certainly over the age of 65.”“When it comes to healthspan and longevity, we're probably never going to have great randomized placebo-controlled studies because simply nobody's going to pay for that and it would take way too long to start people at 50 and then follow them for 40 or 50 years to see who lives longer; that would be hard.”“I started statin when I was 35, I'm 49 now, just because I had a strong family history of heart disease and that was most likely going to be the thing that would kill me later in life.”“I take statins because there are hundreds of different randomized placebo-controlled, well done studies that show a direct correlation: the lower you get your LDL, the less likely you are to have a cardiac event. You know, what we call MACE, or a major adverse cardiac event. So the lower you go the better.”Say hi to the AGEIST team!