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Paul Saladino MD podcast

Latest episodes

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Oct 8, 2019 • 2h 33min

15. The carnivore vs omnivore friendly debate with Chris Masterjohn, PhD., part I

Chris has a PhD in nutritional sciences, which he earned in 2012, from the University of Connecticut. He then did a post-doctoral fellowship before serving as an assistant professor at Brooklyn College until he decided to leave academia and do research on his own. He currently produces a radical podcast, Mastering Nutrition, writes about all kinds of cool stuff at chrismasterjohnphd.com, trains BJJ and loves his liver and egg yolks.    Chris’ contact info  Insta: @chrismasterjohnphd Twitter: @chrismasterjohnphd Web: www.chrismasterjohnphd.com 13:14 Dioxins in food.  19:15 Dioxins in organic animal food.  21:23 Methionine to Glycine ratio. 32:10 Nutritional deficiencies in paleolithic people. 34:10 Bio individuality/diversity 42:46 Deficiencies that arise from eating only muscle meat. 44:05 Vitamin C 51:10 Weston A. Price/the Arctic/scurvy risk. 1:03:10 Ketogenic diets, oxidative stress, and vitamin c.  1:04:47 Insulin 1:12:32 Antioxidant status. 1:29:07 Folate. 1:32:53 Riboflavin. 1:37:14 Manganese. 1:40:08 Dextrose powder. 1:44:07 Potassium/sodium. 2:01:40 Hunter gatherer diets now vs. 80 000 years ago. 2:10:40 The Maasai. 2:15:45 Vitamin K 2:25:40 The most radical thing Chris has done recently.  Ancestral Supplements https://ancestralsupplements.com/   Code SALADINOMD on the shopify site to receive 10% off.   Use the code CARNIVOREMD at www.whiteoakpastures.com all month for 10% off your order!   JOOVV: www.joovv.com/paul   Native: For 20% off your first purchase, visit nativedeodorant.com and use promo code SALADINO during checkout! INSIDER: carnivoremd.com   My contact information: PATREON: https://www.patreon.com/paulsaladinomd   SOCIAL MEDIA 
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Oct 1, 2019 • 2h 20min

14. Paradigm shifting treatment of schizophenia and bipolar disoder with a ketogenic diet, with Harvard MD , Chris Palmer

Christopher M. Palmer, MD, received his medical degree from Washington University School of Medicine and completed his internship and psychiatry residency at McLean Hospital, Massachusetts General Hospital, and Harvard Medical School. He is currently the director of the Department of Postgraduate and Continuing Education at McLean Hospital and an assistant professor of psychiatry at Harvard Medical School. For over 20 years, Dr. Palmer’s clinical work has focused on treatment resistant cases. His research is on the common co-morbidities of mental disorders and metabolic disorders, such as obesity, diabetes, and heart disease. He has recently been pioneering the use of the ketogenic diet in psychiatry, especially for treatment resistant cases of mood and psychotic disorders.   Time stamps: 9:33 What is going on in the brain in regards to mental illness.(schizophrenia,anxiety,depression etc.) And why the ketogenic diet is relevant.   23:53 The root cause of mental illnesses/ trouble with current treatments. 34:34 What is driving these psychiatric illnesses.  45:30 Lactate and metabolic dysfunction. 51:49 The gut microbiome.  56:30 Antipsychotics and mitochondrial dysfunction.  1:01:00 Excess glucose and mitochondrial dysfunction.  1:05:33 How to override insulin resistance. 1:12:36 Metabolic Intervention. 1:18:32 Success stories/case studies and schizophrenia.  1:33:38 How Chris constructs a therapeutic  ketogenic diet. 1:42:30 Chris' experiences on the ketogenic diet.  1:55:43 The possibility of a health revolution (paradigm shift). 2:08:02 Where to find Chris and his studies. 2:12:41 The most radical thing Chris has done recently. Ancestral Supplements https://ancestralsupplements.com/   Code SALADINOMD on the shopify site to receive 10% off.   Use the code CARNIVOREMD at www.whiteoakpastures.com all month for 10% off your order!   JOOVV: www.joovv.com/paul   Native: For 20% off your first purchase, visit nativedeodorant.com and use promo code SALADINO during checkout! INSIDER: carnivoremd.com   My contact information: PATREON: https://www.patreon.com/paulsaladinomd   SOCIAL MEDIA  Instagram:
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Sep 24, 2019 • 1h 53min

13. The atomic particle that will change your life...deuterium!

My guests this week are two of the founders of the Center for Deuterium Depletion.  T. Que Collins, PhD is co-Founder and Principal Investigator, Cignature Health Metabolic Clinic – the first clinic in the world to use deuterium and tracer technologies to describe and follow the health status of patients with metabolic disorders such as cancer, diabetes, and autoimmune disorders. A native of Australia, Dr. Anne Cooper, D.C., LAc. earned her Doctorate in Chiropractic from Cleveland Chiropractic College (Los Angeles), graduating with Honors in 1997, while on the Dean’s list and winning the Charles Gibson award for clinical excellence. Her growing commitment to total health and innovative healing therapies led her to continue on with over 20 years post doctoral experience in Functional Medicine and a Masters degree in Acupuncture and Traditional Chinese Medicine, graduating with highest honors in 2011. Early in her career, as a celebrity aesthetician, working with great beauties such as Ava Gabor, she realized that where there is beauty, there MUST be health and that health must be established on a very deep cellular level. Time stamps: 8:45 Clinical Success Stories. 14:44 Different Stages of Cancer. 15:55 What is Deuterium ? 24:22 Where did it come from? 28:25 Prokaryotic and eukaryotic organisms. 29:10 The creation of mitochondria. 31:30 How does energy work in the body. 34:15 Metabolic water. 35:55 Metabolism  39:25 How do we get too much deuterium? 41:37 How do we take in and deplete deuterium? 43:31 Which foods are the highest in deuterium ? 44:21 How does the sun deplete deuterium? 48:10 Where do plants put deuterium? 50:45 Farming practices affecting deuterium in food. 53:00 The low deuterium diet. 56:41 How do we deplete deuterium ? 58:50 Breathing methods. 1:00:25 How do we deplete deuterium while we sleep? 1:03:20 How sleep is fixed to make for better deuterium depletion. 1:04:58 Is the carnivore diet working through deuterium depletion? 1:06:15 Deuterium levels in different organs of the animal. 1:08:10 Other deuterium depletion methods. 1:11:29 How does deuterium affect cholesterol molecules? 1:14:45 Deuterium and autoimmunity. 1:16:27 Why don't we deplete deuterium as well when we are older? 1:19:01 When do we need deuterium? 1:23:00 How to measure deuterium in the body. 1:25:19 DNA and its structure with deuterium. 1:26:33 Telomeres.
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Sep 17, 2019 • 1h 46min

12. Zsofia Clemens on reversing Type 1 diabetes, Crohns, and cancer with a high fat, nose to tail carnivore diet

Dr. Zsofia Clemens is a biologist and clinical researcher specialized in nutrition, nutritional therapy and brain research. Previously she has been affiliated with the National Institute of Clinical Neuroscience, Budapest and the Neurological Department, University of Pécs, Hungary. Currently she is the leader of the ICMNI / Paleomedicina Hungary. In international academic journals, she has published 40 research articles with more than 1100 citations. www.paleomedicina.com   Ancestral Supplements https://ancestralsupplements.com/   Code SALADINOMD on the shopify site to receive 10% off.   Use the code CARNIVOREMD at www.whiteoakpastures.com all month for 10% off your order!   JOOVV: www.joovv.com/paul   Native: For 20% off your first purchase, visit nativedeodorant.com and use promo code SALADINO during checkout! INSIDER: carnivoremd.com   My contact information: PATREON: https://www.patreon.com/paulsaladinomd   SOCIAL MEDIA  Instagram: @carnivoremd Website: carnivoremd.com Twitter:@carnivoremd  Facebook: Paul Saladino MD email: drpaul@carnivoremd.com Be sure to subscribe for more medicine and lifestyle content. Stay radical!  
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Sep 10, 2019 • 1h 43min

11. Mikhaila Peterson on curing autoimmune disease and depression with the carnivore diet

Mikhaila Peterson, a 27 year old mother of one, runs the blog “Don’t Eat That”. She was diagnosed with juvenile idiopathic arthritis at age 7, severe depression at age 10 and idiopathic hypersomnia at age 21. She had multiple joints replaced at age 17. After years of research trying to solve her autoimmune problems, she went paleo/low carb and eventually ended up on the beef, salt and water diet which resolved her conditions. She’s now off of all medications and in complete remission. She’s raising awareness about the options that are still out there when people can’t seem to get their autoimmune symptoms completely under control.   Time stamps: 8:05  Mikhaila Peterson's carnivore diet story. 31:56 Celiac genes. 33:59 Timeframe with which things got better. 35:35 Symptom length. 45:55 Microbiome and the Carnivore Diet.  49:53 Is it possible to eat a carnivore diet long term?  52:39 Mikhaila's  carnivore journey (how she feels/what she eats). 1:00:58 Carnivore diet criticisms from Kevin Bass and others. 1:05:17How much fat is Mikhaila eating? 1:06:05 Weight Loss/maintenance on the carnivore diet. 1:08:02 Fasting. 1:13:23 Gaining weight on a carnivore diet. 1:14:40 Broken satiety signaling pathways (leptin resistance). 1:16:16 Mikhaila 's bloodwork. 1:19:54 Menstrual cycles. 1:24:49 Jordan Peterson's diet.  1:28:28 Carnivore diet potential /value of exercise.  1:31:43 How do we move the carnivore diet forward? 1:35:05 Where to find Mikhaila  1:36:23 The most radical thing Mikhaila did in the last month          youtube: youtube.com/mikhailapeterson1 facebook: www.facebook.com/thecarnivorediet instagram: mikhailapeterson twitter: MikhailaAleksis website: mikhailapeterson.com   Ancestral Supplements https://ancestralsupplements.com/   Code SALADINOMD on the shopify site to receive 10% off.   Use the code CARNIVOREMD at www.whiteoakpastures.com all month for 10% off your order!   JOOVV: www.joovv.com/paul  
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Sep 3, 2019 • 2h 20min

10. The ULTIMATE bloodwork podcast!

My buddy Nathan Owens (@nathanequalsone) returns for a rousing discussion of all of our bloodwork. There’s a lot here, and this is technical episode. I hope that it provides value to the community and is helpful to those of you with questions about which bloodwork to order!    Time stamps:   12:25 Nathan's Podcast info. 15:04 Blood work Recommendations. 19:38 Where to order these tests online. 20:22 Extra-curricular labs. 21:42 Nathan's Blood Work-Cholesterol 24:01 What happened to  basic lipid panel when he went carnivore. 25:55 Familial hypercholesterolemia 27:15 Thoughts on why LDL goes up on a Carnivore Diet. 29:04 Sophisticated lipid panels  30:48 Atherogenic lipid numbers. 32:31 Nathan's LDL and HDL size. 33:50 What's the size of an HDL particle relative to the size of an LDL particle? 38:07 Ox LDL test. 41:20 Paul's bloodwork results. 43:14 LPPAL2 45:09Other lipid tests Nathan got. 47:05 Are plant sterols atherogenic? 48:35 Other inflammatory markers  49:38 Valuable Inflammatory Markers. 51:00 When to measure HSCRP? 51:39 Myloperoxidase and fibrinogen. 52:12 Homosistine. 54:50 Plant Folate  56:15 Hormones 57:53 Sex hormone binding globulin. 1:01:49 What Nathan did to quadruple his testosterone. 1:06:30 The takeaways in regards to testosterone  1:09:40 DHT  1:12:21 IGF1 1:13:25 Insulin 1:14:10 Importance of testing fasting insulin. 1:14:25 C peptide measurements  1:14:45 The Comprehensive Metabolic Panel. 1:16:37: B.U.N  1:18:27 Cystatin c  1:19:19 EGFR 1:19;54 Fasting glucose.  1:21:59 Continuous glucose monitoring.  1:23:13 Hemaglobin A1C. 123:53 Fructosamine levels. 1:24:44 Bilirubin  1:26:59 Biliary disease  1:28:58 ALT and AST 1:29:30 Alkaline Phosphatase. 1:30:16: GGT  1:31:53 CBC and DIFF. 1;33:58: Wh
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Aug 27, 2019 • 2h 6min

9. Dave Feldman and Siobhan Huggins return for the ULTIMATE lipid podcast, the roots of insulin resistance, hs-CRP and Lp(a)

If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not,  you’ve got some homework to do, and I think you’ll be amazed at what you find. Dave’s work can found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it.  He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks. He’s since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. Where he induced a 73 point drop in my LDL-C and a 1115 point drop in my LDL-P.  Siobhan (she'-VAUN) Huggins is an independent researcher focused on lipidology, the immune system, and metabolic diseases. She spends most of her time at cholesterolcode.com where she works alongside Dave Feldman. She has been keto since August of 2016, and on a predominantly carnivorous diet as of October 2017. She has lost 80 lbs, reversed hypertension, and found a passion for research along the way. 5:47 Dave Feldman's blood testing at low carb San Diego 7:17 The Feldman Protocol 9:39 Does it matter whether subjects are a ketogenic vs. carbohydrate based metabolism 11:19 What labs were administered? 13:03 Shevawn(Siobhan??) on the inflammatory markers. 14:09 What's the sense of the half-life of HSCRP? 18:09 Ferritin 22:34 Other Markers being tested? 25:29 Glucagon 27:17 is it expected from these labs to find free fatty acids in the blood ? 29:23 What do you use as a cutoff for high fasting insulin? 30:00: C-Peptide 32:55 Hemaglobin A1C 34:37 Test frequency/pitfalls of looking at tests in isolation. 38:09 The Lipid Panel ,(triglycerides) 42:42 How are Triglycerides different from free fatty acids? 45:22 Measuring Triglycerides. What Happens to triglycerides after eating a high fat Carnivore meal? 50:13 Any utility to non-fasted lipid panels ? 50:52 Will triglycerides be higher on a Ketogenic diet (postprandially) 51:39 difference in postprandial triglycerides between Keto and carbohydrate based metabolisms.  54:14 Recommendations around Triglycerides. 58:32 What else elevates triglycerides? 1:01:39 Thoughts on Coffee 1:04:56 National Health and Nutritional Survey. 1:06:49 How many people are in this data set? 1:08:15 What is linear regression? 1:11:58 Why Dave wanted to look at all cause mortality. 1:13:52 Ldl and all cause mortality  1:14:57 Age parity  1:16:37 "The Dave Dance" 1:17:52 Critique:diseases that bring down LDL. 1:20:59 What epidemiology is useful for. 123:32 What happened when those who died within 10 years. 1:23:22 How many people ended up in the age parity subset? 1:25:20 How could LDL be good for you? 1:31:57 Evolutionary role of insulin resistance.
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Aug 20, 2019 • 1h 25min

8. Ben Greenfield on his experiences with the Carnivore diet, eating testicles, cleansing his colon, and using peptides to become one of the Avengers.

Ben Greenfield is a force of nature who truly needs no introduction but here’s a bit I pulled from his website: In 2013 and 2014, Ben was named as one of the world’s top 100 most influential people in health and fitness, and by 2015, Ben was coaching the world’s top CEO’s, chefs, biohackers, poker players, tennis, motocross and endurance competitors, and professional athletes from the UFC, the NHL, the NBA, the NFL and beyond – all while advising and investing in top companies in the health, fitness and nutrition industry.  In 2016, he joined Spartan SGX as one of its certified coaches. As founder and CEO of Kion, Ben now creates step-by-step solutions – from supplements and fitness gear, to coaching and consulting, to education and media – for the world’s hard-charging, high-achievers to live a truly limitless life with fully optimized minds, bodies and spirits – all from his quiet home on 10 acres in the forested wilderness of Washington state.     Time stamps:   8:22 The Swiss Mountain Clinic stories 21:24 Ben's children's experience at the clinic. 25:09 Results of Ben's carnivore diet. 32:02 Ben's takeaways from the carnivore diet. 34:04 Eating animal brains and other organs. 38:04 Sourcing meat (U.S. Wellness and hunting). 46:04 What are lions fed in captivity (San Diego) 47:14 Ben's experiences at a survival training camp. 49:04 Miki Ben Dor's analysis of energy expenditure while hunting animals. 50:24 Hunting bigger animals for fat. 52:00 Edible Wild Plants. 55:35 Paul's cattail story. 58:49 Are there medicinal uses for plants? 1:00:04 Paul's foray into raw veganism. 1:02:38 Peptides. 1:07:04 How epitalon works for longevity/how often Ben takes peptides. 1:08:39 What Ben is taking currently. 1:12:04 The mechanisms of peptides effect on the brain. 1:13:04 The most radical thing Ben has done recently.   Ben’s contact info: Web: BenGreenfieldfitness.com instagram: @bengreenfieldfitness     Ancestral Supplements https://ancestralsupplements.com/   Code SALADINOMD on the shopify site to receive 10% off.   JOOVV: www.joovv.com/paul   INSIDER: carnivoremd.com   My contact information: PATREON:
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Aug 13, 2019 • 1h 40min

7. Tommy Wood, MD, PhD. Should you worry about ApoE4 on a keto/carnivore diet and how to avoid Alzheimer’s disease

Tommy Wood MD, PhD is an elite-level professional nerd who has coached world class athletes in a dozen sports.  He has an undergraduate degree in biochemistry from the University of Cambridge, a medical degree from the University of Oxford, and a PhD in physiology and neuroscience from the University of Oslo. Tommy is a Research Assistant Professor at the University of Washington, a Research Scientist at the Institute for Human and Machine cognition, and is on the scientific advisory board of Hintsa Performance. He is also CSO (Chief Snake Officer) at the Costa Rican Center for Bro Research. Tommy lives in Seattle with his wife Elizabeth and their two goofy boxers. In his spare time he can usually be found cooking, reading, or lifting something heavy.   Time stamps 8:27 APOE4 Gene 11:37 Background on APO lipoproteins  15:00 APOC3 15:47 APO interference on LDL receptors  17 19:17 Insulin resistance and LDL residence time(reverse causation). 20:37 Metabolic Disease of the American Population. 22:07 David Foster Wallace, "This is Water" 24:18 Is Insulin Resistance driving LDL reten? 28:09 What is  APOE doing in the periphery? 29:08 Immunologic functions of lipoproteins.  30:46 Are higher levels of LDL protective? 32:07 How higher total cholesterol predicts longevity in a "normal" person. 33:38 APOE and the brain. 34:47 Ketones as precursor for cholesterol synthesis. 35:27 Newborns and ketosis. 36:05 Glucose,ketones, and cholesterol. 37:12 Glial cells in the brain. 40:22 How the APOE genes differ. 44:57 Why are people told not to eat high saturated fat when they have the APOE4 gene? 47:37 Confusion around keto/carnivore diets raising total cholesterol  49:17 The Bolivian Tsimonae. 53:52 APOE and evolutionary history. 54:19 Evolutionary pressure and longevity. 56:02 Miki Ben-Dor's findings on longevity of our ancestors. 57:40 Why APOE4 is beneficial from an infection standpoint. 1:00:10 Difference between refined and unrefined saturated fat. 1:03:02 Liquid fats effect on the gut. 1:03:17 Statins. 1:04::54 COQ10 levels in carnivores. 1:07:02 Lipophilic statins. 1:08:40 Statins and Dementia. 1:09:14 Amyloid hypothesis of Alzheimer's. 1:14:22 Problems with western medical education. 1:15:13 How is the system broken? 1:16:17 Insulin Resistance and
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Aug 6, 2019 • 1h 34min

6. Where the heck did these crazy nutritional guidelines come from, anyway? Revisionist history with Gary Fettke, MD

Dr Gary Fettke is an Orthopaedic Surgeon practising in Launceston, Tasmania, Australia. He has a major interest in the preventative medicine and encourages his patients to lose weight before undergoing surgery. Although his speciality is surgery, Gary believes it is much better to help people avoid surgery by taking preventative measures, which often involves primarily altering the diet. He is an advocate of a Low Carbohydrate Healthy Fat (LCHF) lifestyle for the health benefits. He was “a fat kid” and has experienced ‘too many’ other health issues until changing his diet and lifestyle. He has concerns that as we get older the health systems will be under significant stress from financial and health burden aspects. It is simply unsustainable – a train crash in evolution. In recent years Gary has focussed on the role of diet in the development of diabetes, obesity and cancer. He has been speaking out internationally on the combined role of sugar, fructose, refined carbohydrates and polyunsaturated oils linking together to be behind inflammation and modern disease. Gary remains committed to understanding the central role of nutrition in everything ranging from our health issues to its role in influencing education, the environmental impact, economics, politics and belief systems. He has incurred the wrath of regulatory bodies for his stand on public health, but he and his wife, Belinda, remain active defending the benefits of low carb healthy fat living. Their ongoing work has uncovered the vested interests and ideologies shaping nutritional guidelines at an international level.   Gary Fettke, MD contact info: Website: isupportgary.com Ig: @isupportgary Twitter:@fructoseno   Time stamps:   8:56 Gary's story. 15:17 Cereal industry "conspiracy" 22:32 Being told that he was unable to give nutritional advice. 25:40 What were the complaints saying? 28:09 Tim Noakes' similar situation. 30:45 Banting diet 32:17 Why is sugar toxic  38:07 Grains and cereals (polyol pathway) 40:32 Non-evolutionarily consistent food  43:02 Our own "Brave New World" 44:37 Belinda Fetke's work. 47:37 The role of the Seventh Day Adventists church. 52:22 Kellogg's cereal involvement. 54:35 Who influenced Ancel Keys? 57:37 Article on Seventh Day Adventist role in nutritional guidelines in Journal of Religion. 1:01:42 Religious ideology and the U.S. food guidelines. 1:03:55 Seventh Day Adventists and the soy and alternative meat industry. 1:06:27 Seventh Day Adventists and medical education. 1:11:54 Coca-Cola and the Seventh Day Adventist. 1:15:44 Cereal

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