NEJM This Week

Explore the impact of high lipoprotein(a) on heart disease and innovative RNA therapies like lepodicerin. Discover groundbreaking lentiviral gene therapy for severe immune disorders and its accessibility challenges. Dive into COPD management with mepolizumab, which shows promise but lacks quality-of-life benefits. Delve into the serious health risks of alcohol consumption and potential policy solutions. Finally, hear an inspiring story of resilience and camaraderie between a cancer patient and his doctor.

Featuring articles on bronchiectasis, influenza, clonal hematopoiesis of indeterminate potential, and metachromatic leukodystrophy; a review article on biology of the Fc neonatal receptor; a case report of a woman with sore throat and rash; and Perspectives on HIV preexposure prophylaxis, on fossil fuels, and on Medicaid’s mandate for children and adolescents.

Discover the latest advances in lupus nephritis treatment with obinutuzumab and tecovirimat's role in combating mpox. Dive into a clinical comparison of pulsed field versus cryoballoon ablation for atrial fibrillation. Uncover breakthroughs in hemophilia B therapy and the vital need for proper nutrition in hospitalized patients. Reflect on the implications of the U.S. withdrawal from the WHO and evolving nicotine regulations. Lastly, explore changing healthcare spending trends and the historical impact of physicians during revolutionary times.

Featuring articles on cancer-associated venous thromboembolism, endovascular treatment for stroke, dapagliflozin in patients undergoing TAVI, screening for prostate cancer, and extrachromosomal DNA; a review article on otitis media in young children; a case report of a woman with flank pain, fever, and hypoxemia; and Perspectives on some efforts toward equity and on breaking the sacred promise.