NEJM This Week NEJM This Week — June 5, 2025
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Jun 4, 2025 Discover groundbreaking advancements in metabolic dysfunction and innovative approaches to lung nodule evaluation. Dive into the impact of race on healthcare diagnostics and the consequences of funding cuts on medical research. Explore the implications of immigration enforcement on patient rights and the struggles of vulnerable populations. Gain insights from clinical trials on birth outcomes and the evolving landscape of hemoglobin disorders, all while navigating critical conversations around equity and access in healthcare.
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Semaglutide Advances MASH Treatment
- Semaglutide significantly improves metabolic dysfunction-associated steatohepatitis (MASH) resolution and fibrosis regression.
- However, benefits are modest, indicating many patients still need additional therapy.
Bronchoscopy Vs Needle Biopsy
- Navigational bronchoscopy shows comparable or better diagnostic accuracy than transthoracic needle biopsy for lung nodules.
- Expertise and equipment availability influence the generalizability of these findings.
Nodal Irradiation Not Always Beneficial
- Regional nodal irradiation adds no benefit for breast cancer patients with tumor-negative nodes post-neoadjuvant chemotherapy.
- This challenges the routine use of nodal irradiation in such cases.