Plain English with Derek Thompson

Ziyad Al-Aly, a physician-scientist from Washington University in St. Louis, co-authored a paper exploring the groundbreaking effects of GLP-1 drugs. The conversation highlights how these drugs extend beyond diabetes treatment, potentially aiding in reducing risks for substance abuse, neurocognitive disorders, and even conditions like Alzheimer's. Al-Aly discusses the implications of these findings on our understanding of free will and behavior. He also calls for more research to fully unlock the transformative potential of GLP-1 medications.

In this engaging discussion, Kevin Roose, a New York Times columnist and host of the Hard Fork podcast, sheds light on the controversial future of TikTok and its influence on Gen Z, particularly amidst its legal battles in the U.S. The conversation turns to the rapidly advancing world of AI, with experts predicting breakthroughs that could reshape technology. Roose also delves into the rise of meme coins in the crypto scene, exploring their implications on financial culture and governance amid national security concerns. A thought-provoking listen!

Candice Millard, a historian and author of the bestseller "Destiny of the Republic," dives into the unfortunate tale of President James Garfield. She explores Garfield's rise from humble beginnings to the presidency and the chaotic atmosphere of the 1876 Centennial Exhibition. The discussion highlights the intersection of innovation and medicine, revealing the medical failures that plagued Garfield following his assassination. Millard also brings Charles Gouteau's unsettling obsession into focus, illustrating how mental health and politics clashed in this tragic chapter of American history.

Tim Stockwell, a Canadian health researcher and advocate for scrutinizing moderate drinking's benefits, joins the conversation. He delves into the health implications of moderate alcohol consumption, challenging the traditional J-shaped curve theory. Stockwell highlights the complexities of observational studies, discussing their limitations in understanding alcohol's true effects. He also re-evaluates public health guidelines, particularly in light of new findings linking alcohol consumption to cancer risk, prompting listeners to reconsider their drinking habits.

Robinson Meyer, founder of Heatmap News and former Atlantic writer, dives deep into the recent Los Angeles wildfires. He discusses the unusual nature of these fires and their connection to climate change. The conversation spans the destructive force of Santa Ana winds and the need for improved fire management policies. Meyer also highlights innovative solutions like controlled burns, community preparedness, and the role of new technologies in wildfire prevention. It's a critical look at how urban planning must evolve to face future disasters.

In this discussion, Nick Epley, a behavioral science professor at the University of Chicago, dives into America's growing epidemic of solitude. He reveals how our loneliness affects our happiness, relationships, and even our culture. Epley highlights the importance of 'social fitness' and the need for genuine connections. He contrasts digital interactions with face-to-face communication, stressing the transformative power of deep conversations. Listeners learn why embracing social ties can enhance their lives amid a rapidly isolating society.

Michael Cembalest, Chairman of market and investment strategy at JPMorgan Asset Management and author of 'Eye on the Market', dives into the 2025 economy forecast. He discusses the unparalleled influence of the MAG-7 tech giants and their link to skyrocketing AI investments. Cembalest explores the potential revival of nuclear energy amid rising tech demands, while dissecting Europe's economic struggles versus the U.S. Lastly, he unpacks the complex challenges facing China and how Trump's policies intertwine with these global economic dynamics.

Scott Aaronson, a theoretical computer scientist from the University of Texas at Austin, helps demystify quantum computing, exploring concepts like superposition and entanglement. He highlights the transformative power of qubits and discusses their potential societal impacts. Eric Topol, a renowned American cardiologist and founder of the Scripps Research Translational Institute, delves into groundbreaking advancements in HIV prevention with lenacapivir and shares insights on innovative blood tests in proteomics, paving the way for personalized medicine.

Joining the discussion is Charles Fain Lehman, a Fellow at the Manhattan Institute, who specializes in analyzing trends in drugs and violence in America. He addresses why the U.S. has high mortality rates compared to other wealthy nations. Surprisingly, he reveals a recent decline in drug deaths, murders, and obesity rates, hinting at a possible health wave. Lehman explores the paradox of rising drug accessibility despite declining overdose rates and analyzes how social disruptions during the pandemic might have influenced crime trends.

Joining the conversation is Oliver Burkeman, a renowned author known for his work on time management and productivity, including 'Four Thousand Weeks.' He discusses the paradox of productivity and how accepting our limitations can lead to genuine freedom. Burkeman explores the notion that life's chaos isn't a curse but an essential part of being alive. He advocates for prioritizing deep work while embracing unpredictability—suggesting that joy often stems from relinquishing the need for control and perfection.