Euan Ashley, a professor of genomics and cardiovascular medicine at Stanford, discusses the incredible effects of exercise on health. He explains how exercise acts as a powerful medical intervention, transforming our bodies at the molecular level. Ashley highlights gender differences in exercise benefits and the evolutionary history that shaped our physical activity. The conversation also touches on the tantalizing idea of an 'exercise pill' that could mimic workout benefits without sweating, pushing the boundaries of exercise science.

Derek reviews the Democratic National Convention and its influence on the 2024 election. He discusses how Kamala Harris' candidacy affects perceptions of competitiveness. Despite a hint of optimism, polling suggests a tight race ahead. The volatile political landscape means voter preferences could shift dramatically. The podcast also highlights the importance of messaging tone as Democrats face challenges from the Trump campaign. Overall, a cautionary take on the excitement surrounding the election.

David Broockman, a political scientist at UC Berkeley, and Josh Kalla, coauthor of a thought-provoking essay on political persuasion, break down common misconceptions surrounding how we change minds. They discuss the interplay of moral foundations in political messaging and analyze the fallout of negative campaigning. The duo also explores voter apathy and the myth of informed swing voters. Throughout the conversation, they emphasize the need for adaptable strategies, highlighting the complex dynamics of belief change amid the evolving political landscape.

Laurie Santos, a Yale cognitive scientist and host of the ‘Happiness Lab’ podcast, shares her insights on happiness research. Discover how our perceptions of time shape our well-being, from grappling with regrets to harnessing nostalgia. She explains the concept of psychological distancing to reduce anxiety and illustrates how writing to our future selves can enhance happiness. Dive into the importance of genuine connections, the effects of technology on social interactions, and the intricate balance between fleeting joy and lasting life satisfaction.

Conor Sen, a Bloomberg expert on economic and financial trends, delves into the current market turmoil and recession fears. He discusses the disappointing jobs report and the impact of the Yen Carry Trade on global finance. Sen critiques and defends the Federal Reserve's recent decision on interest rates while exploring the tension between AI advancements and profitability challenges in tech. He emphasizes the need for a long-term perspective amidst market fluctuations and highlights potential interest rate cuts to ease economic pressures.

Derek is joined by Joshua Bercu, the executive director of Industry Traceback Group, to discuss the persistent nuisance of robocalls. They explore how the average American faces daily spam, the tactics scammers use, and the challenges of regulation. Joshua explains the evolution of robocall technology and the cooperation between the government and industry to combat this issue. The duo also delves into the dark role AI plays in facilitating scams, raising awareness about the threats posed by new technologies.

Exploring the happiness gap between American conservatives and progressives, with conservatives being happier despite lower trust in institutions. Studies show progressives are more depressed than conservatives. The impact of cognitive behavioral therapy on anxiety and depression is discussed, along with the notion of wealth and fulfillment. Challenges in progressivism include infighting and negative online narratives affecting mental health.

Former Chicago Fed president, Austan Goolsbee, discusses the U.S. economy with Derek Thompson. They talk about the Federal Reserve, high tariffs, housing production, and the future of the economy. Goolsbee shares insights on interest rates, inflation, and labor market responses.

Mike Simonsen and Lance Lambert discuss the bizarre U.S. housing market where high prices persist despite weak demand. They delve into the lock-in effect, high mortgage spreads, and the role of individual investors. The podcast also examines housing market dynamics in different regions, focusing on the booming Austin market and future outlook.

Mark Leibovich, The Atlantic's journalist, discusses Biden's cognitive decline and Democratic hypocrisy. Alex Thompson from Axios weighs in on the White House strategy, media failures, and the potential replacement of Biden by Kamala Harris. The podcast delves into internal debates, pressures on Biden, media reactions, and tensions between Biden and Harris camps.