Plain English with Derek Thompson

If GLP-1 Drugs Are Good for Everything, Should We All Be on Them?

334 snips
Sep 16, 2025
David D’Alessio, chief of endocrinology and metabolism at Duke University, and Randy Seeley, a professor at the University of Michigan, delve into the groundbreaking GLP-1 drugs like Ozempic. They reveal these drugs’ potential to combat not just Type 2 diabetes and obesity, but also addictions, migraines, and even neurological diseases like Alzheimer’s. The discussion uncovers the science behind why these medications perform so many functions and considers the implications of making them more widely available for general health.
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INSIGHT

Why GLP-1s Seem To Do Everything

  • GLP-1 drugs activate multiple body systems because their receptors sit in gut, heart, immune system, and brain.
  • That broad receptor distribution explains why they affect appetite, inflammation, cravings, and more.
INSIGHT

They Turn On The Satiety System

  • GLP-1 drugs reduce appetite by strongly activating the body's satiety systems.
  • High pharmacologic doses drive neural circuits that make people eat fewer calories over time.
INSIGHT

Multiple Paths To Less Eating

  • Multiple mechanisms contribute: slowed gastric emptying, reduced 'food noise', and mild nausea in some patients.
  • The drugs work broadly because dosing overwhelms normal physiology rather than subtly mimicking it.
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