Plain English with Derek Thompson

In a captivating discussion, Dr. Eric Topol, founder of the Scripps Research Translational Institute and bestselling author, shares insights on groundbreaking scientific achievements from 2023. Topics include NASA's asteroid discoveries, revolutionary CRISPR treatments for sickle cell disease, and AI’s role in accelerating vaccine development. The fascinating concept of simultaneous invention illustrates how innovation thrives in collaboration. Plus, hear about promising cancer treatments using engineered bacteria and the transformative impact of GLP-1 medications on diabetes and weight loss.

Boris Heifets, an assistant professor of anesthesiology at Stanford and author of a groundbreaking study on ketamine, dives deep into its dual role as both a battlefield anesthetic and a potential antidepressant. He discusses the rapid rise of ketamine clinics and the complexities behind its effectiveness—raising questions about whether its benefits stem from the drug itself or the patient's experience. They explore the surprising impact of expectation on treatment outcomes, illustrating the intricate dance between belief and healing in mental health.

Matthew Belloni, host of ‘The Town’ at Ringer and a writer for Puck, dives into 2023's tumultuous media landscape. He discusses the cultural phenomenon of 'Barbenheimer' and its marketing implications. The conversation also tackles the impact of recent Hollywood strikes on the industry and creative jobs. Belloni reveals surprising Netflix viewership trends, noting audiences favor engaging, fast-paced content over star power. Lastly, he predicts a rise in live streaming, particularly in sports and awards shows, shaping the future of entertainment.

Zach Reitano, CEO of telehealth platform Ro, discusses the booming GLP-1 drug marketplace and its economic implications. He highlights how these medications could transform obesity treatment by changing eating habits and healthcare dynamics. In contrast, Dr. Robert Lustig, an endocrinologist from UCSF, raises skepticism about their efficacy and long-term health impacts, emphasizing potential side effects like nausea. The conversation challenges traditional views on weight management and stresses the importance of equitable access and multifaceted treatment approaches.

Beverly Tchang, an endocrinologist at Weill Cornell specializing in obesity medicine, delves into the revolutionary impact of GLP-1 weight-loss drugs. She explains how these medications modify appetite and blood sugar regulation, tracing their origins to Gila monster saliva. The conversation also touches on the complex psychological effects, possible misuse, and how these drugs challenge our understanding of free will in relation to hunger and lifestyle choices. Tchang raises thought-provoking questions about the societal implications of this weight-loss revolution.

Mark Zandi, chief economist at Moody’s Analytics and host of the Inside Economics podcast, discusses the current U.S. housing market crisis. He explains why high home prices and mortgage rates are making ownership dreams seem unattainable for many young people. The conversation delves into the impact of remote work on housing preferences and how job stability and wage growth might soon improve affordability. Zandi also highlights potential signs of recovery in the market, with falling mortgage rates and an uptick in building material orders.

Join George Packer, an Atlantic staff writer and author known for ‘Our Man,’ as he delves into the life and legacy of Henry Kissinger, who recently passed away at 100. They discuss the duality of Kissinger’s career—his groundbreaking U.S.-China relations, the moral complexities of his policies during the Vietnam War, and how his realpolitik approach continues to influence global affairs. Packer’s insights provide a captivating look at the triumphs and catastrophes that shaped modern diplomacy.

This discussion features Charlie Warzel, a sharp staff writer at The Atlantic, offering his expertise on technology and social media. He dives into Elon Musk's controversial behavior at a recent summit and its fallout for X, formerly Twitter. Warzel explores the fragmented social media landscape and its effects on both users and creators. He also examines the evolving nature of celebrity in the digital age, highlighting the rise of influencers and the challenges for journalists navigating a chaotic information ecosystem.

In this engaging discussion, Dan Wang, a writer and expert on the Chinese economy and technology, delves into China's economic transformation and its implications for the world. He highlights the stark contrasts between China's rapid growth and its current economic challenges, including high youth unemployment. Wang also emphasizes China’s dominance in the electric vehicle and renewable energy sectors, while critically examining its struggles in the semiconductor industry. The conversation sheds light on the interplay between China's authoritarian governance and its quest for innovation.

Charlie Warzel, a tech reporter for The Atlantic, alongside contributors Karen Hao and Ross Andersen, delves into the chaotic recent events at OpenAI, including CEO Sam Altman's dramatic firing and near rehiring. They discuss the complex corporate structure of OpenAI, the internal power struggles, and the implications for the future of artificial intelligence. With insights into the push for responsible AGI development, the guests explore the tensions between innovation and safety in the rapidly evolving tech landscape.