Plain English with Derek Thompson The Truth About Ketamine: Depression Cure, Health Fad, or Placebo?
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Dec 22, 2023 Boris Heifets, an assistant professor of anesthesiology at Stanford and author of a groundbreaking study on ketamine, dives deep into its dual role as both a battlefield anesthetic and a potential antidepressant. He discusses the rapid rise of ketamine clinics and the complexities behind its effectiveness—raising questions about whether its benefits stem from the drug itself or the patient's experience. They explore the surprising impact of expectation on treatment outcomes, illustrating the intricate dance between belief and healing in mental health.
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Ketamine's History and Rise
- Ketamine, a synthetic drug, has been used medically for over 50 years.
- Initially an anesthetic, its popularity surged due to its efficacy in treating depression.
Accidental Discovery
- Ketamine's antidepressant properties were discovered accidentally while researching schizophrenia treatments.
- Its rapid action and high success rate, even in treatment-resistant depression, set it apart.
Shared Properties of Psychedelic Treatments
- Ketamine, psilocybin, and MDMA share psychoactive properties, rapid antidepressant effects, and lasting relief after single doses.
- This sustained impact sets them apart from traditional antidepressants.