LessWrong (Curated & Popular)

Discussing the concept of creating 'designer babies' with desired traits through gene manipulation. Topics include polygenic scores for predictions, challenges of gene editing, embryo selection, iterated meiosis, naive pluripotent cells, and the uncertainties in creating designer babies.

Exploring the utility of poker in teaching epistemics and decision-making, comparing it to games like Candy Land and Chess. Comparing Figgy with poker as teaching tools, highlighting the advantages of Figgy including more feedback and active participation.

David Gerard, a long-standing critic of rationalist and EA communities, discusses his standards for reliable sources, his involvement with LessWrong and Effective Altruism, conflicts within online communities, and his contentious actions on Wikipedia, leading to bans from editing certain articles.

Guest Rob Bensinger discusses mind uploading, exploring Ship of Theseus concept and personal identity. They tackle questions on caring about uploads as much as biological self, experiencing what uploads do, and decisions on brain destruction for scanning process. The podcast challenges traditional views on identity and consciousness through thought experiments and futuristic scenarios.

Host Raemon discusses the suggestion to remove OpenAI from job boards due to manipulativeness and lack of emphasis on existential safety work. The chapter explores OpenAI's history of behaviors, the need for accountability, and suggestions for rebuilding trust.

A discussion on cancer vaccines, focusing on neoantigens and personalized vaccine development. Topics include methods for protein characterization, innovative techniques in cancer vaccine development, and the use of synthetic long peptides for cancer vaccines.

Explore a hypothetical movement called Effective Samaritans influenced by socialist communities, debating the effectiveness of charity versus societal transformation. Reflect on early beliefs and influences while navigating conflicting priorities in doing good through experimental procedures.

Financial commitments advocate William Howard shares his experience using the Forfeit app to combat akrasia. He discusses the effectiveness of setting financial forfeits for tasks like coding and publishing, tips for task management, and strategies for overcoming procrastination through monetary commitments.

In this podcast, they discuss the significance of fentanyl-detecting machines and their role in countering the fentanyl crisis. They explore advanced technologies like remote detection and X-ray scanners at the US southwest border. The podcast delves into the challenges of chemical compound detection and the impact of these machines on border security.

The podcast delves into the concept of rogue deployments in AI catastrophes, classified based on involvement of rogue deployment. It also discusses challenges in prevention, subcategories of rogue deployments, and different attacker profiles.