John Cleese, comedic legend and author of the memoir 'So, Anyway...', discusses his early life, comedic days at Cambridge, founding Monty Python, and the challenges of making good movies. He reflects on the meaning of life, accessing the unconscious mind for creativity, and the role of political correctness in comedy. With humorous anecdotes and insight, Cleese shares his journey from reluctant performer to world-class actor.

Neil Mullarkey, author of 'In the Moment: Build Your Confidence, Communication and Creativity at Work,' discusses communication tricks and strategies for collaboration and risk-taking. He shares his journey in comedy, the power of improv, and the importance of exploring assumptions. The podcast also explores enhancing lives, addressing polarization, and mnemonic devices for communication and creativity. It ends with embracing improvisation and collaboration for creativity and confidence.

Neuroscientist Ogi Ogas discusses sexual desires and how they relate to diverse erotic interests. Topics include heterosexual men's preferences, gender differences in the perception of erotica, different forms of erotic content and their influence on sexual preferences, study findings on lesbians' interests, the science behind foot fetishes, and research findings on dominance and submission in human sexuality.

Cecil Baldwin discusses his background and how he became part of Welcome to Night Vale. They talk about the origins of Night Vale, collaboration, and recording live shows separately. They also explore the unique nature of Night Vale scripts, the transformation of a character, and their dream project.

Anna Kendrick, actress and author of Scrappy Little Nobody, discusses her rise to fame, funny encounters while shooting Twilight, the challenges of dealing with fame, writing books, navigating career goals, benefits of voice acting, choosing roles in acting, personal experiences, collaborations, and movie ideas, including a buddy cop comedy film.

Shellye Archambeau, former Silicon Valley CEO and author, discusses her book 'Unapologetically Ambitious' in which she shares her personal and professional journey. She emphasizes the importance of being ambitious and working towards goals, having a plan and being adaptable, the pressure of sacrificing for others, the power of asking for help and building leadership skills, and taking ownership of your career.

Guest Morra Aarons-Mele, author of “The Anxious Achiever: Turn Your Biggest Fears into Your Leadership Superpower,” discusses the importance of addressing anxiety in the workplace and how it can be harnessed as a strength. She shares personal insights on finding purpose, embracing mental health, and making difficult decisions. The podcast provides tools for managing anxiety and creating mentally healthy teams and culture.

Jamie Jones, expert in the evolution, ecology, and adaptation of the human species, discusses the paradox of human irrational decision-making in a successful species. The talk explores the role of evolution in decision-making, challenges of avoiding extinction, social signaling, tribal societies, in-group and out-group identities, and the impact of demographic transition on human fertility.

Kristy Hamilton, author of 'Nature's Wild Ideas: How the Natural World is Inspiring Scientific Innovation', explores examples of biomimicry where scientists find solutions in nature. Topics include lobster-inspired telescopes, lizard-inspired medication, and coral-inspired emission reduction in cement manufacturing. The book highlights the importance of conservation and features memorable experiences from field research and virtual lab tours.

Viv Groskop, an award-winning writer, comedian, and presenter, shares practical tips for being confident without appearing overconfident. She discusses the multifaceted concept of confidence and explores generational differences in conforming to norms. The podcast also delves into the unique characteristics of the younger generation and the importance of embracing one's unique self under pressure. The speaker emphasizes the significance of context, authenticity, and developing alter egos for confidence and high status.