Albert Bourla, CEO of Pfizer, discusses the company's focus on innovative cancer treatments and the role of AI in drug development. Ray Dalio shares insights on rising global debt, urging smart management for economic stability. Matthew Schrag, a neurologist at Vanderbilt, raises red flags about research integrity in Alzheimer's treatments, stressing the urgent need for accountability in scientific studies. Together, they explore the intersection of healthcare innovation and economic challenges, emphasizing the importance of prioritizing effective therapies.

President Trump's new tariffs on imports from Canada, Mexico, and China have sent shockwaves through global stock markets. There's a looming trade war as he plans talks with Canadian and Mexican leaders amidst concerns about rising consumer prices. The automotive industry is bracing for a potential $3,000 hike in car costs. Meanwhile, reactions from Canada and Mexico reveal deep concerns, while China's response hints at possible ripples in international relations. The geopolitical landscape is shifting rapidly with these bold economic moves.

Explore the origins of the Federal Reserve's 2% inflation target and how it's perceived differently across the U.S. Delve into the challenges facing New York City's office real estate, contrasting premium buildings with struggling ones. Discover the evolving dynamics of the market, influenced by remote work trends and changing tenant expectations. Plus, hear how a quirky story about da Vinci ties into modern efficiency and the importance of seeking help for personal growth!

A new Chinese AI startup, DeepSeek, is shaking up the tech industry with cost-effective models using less advanced chips, challenging the dominance of big American companies. The buzz is causing investors to worry about inflated stock values and shifting market dynamics. With DeepSeek leading download charts amid US sanctions, discussions surround its impact on pricing and demand for chips used by tech giants like Nvidia. The conversation also touches on mental health support, adding an insightful layer amidst the market tumult.

Discover how traditional finance is evolving with mobile banking and cryptocurrency. The conversation highlights Bitcoin's role and the new investment avenues it creates. Dive into the transformative power of blockchain in enhancing transparency and risk management. Learn about tokenization’s potential to decrease costs and boost returns in investment portfolios. Plus, explore the integration of innovative technologies within the financial sector and the influx of institutional interest in crypto.

Afsani Beshlas, an expert on the World Economic Forum, dives into the challenges facing the insurance industry in the wake of devastating wildfires in Los Angeles. She offers insights into urban planning and the need for strategic changes to address climate impacts. The discussion also touches on immigration enforcement and its economic implications, alongside the rising trend of non-alcoholic beverages. Beshlas highlights shifting cultural attitudes towards drinking, emphasizing health and wellness among younger consumers.

Lindsay Chervinsky, a Presidential historian and executive director of the George Washington Presidential Library, shares her insights on Donald Trump's inauguration and its historical significance. She discusses Trump's vision of a 'golden age' for America, emphasizing sovereignty and safety. The conversation dives into the symbolic importance of the peaceful transition of power and the potential impacts of Trump's policies on energy, immigration, and U.S.-China relations. Chervinsky highlights the need for smart investment strategies in this evolving political landscape.

This week, we look at what the next Trump administration will do to deliver on its promises to make government smaller, negotiate more favorable trade deals, and sustain economic prosperity. We talk to BlackRock's Rick Rieder, Council on Foreign Relations' Michael Froman, PIMCO's Libby Cantrill, Apollo's Torsten Slok, and Committee for a Responsible Federal Budget's Maya MacGuineas.See omnystudio.com/listener for privacy information.

It’s been a rough week for UK assets. The pound fell to its lowest level in a year, gilt yields surged and investors are losing confidence in the government’s ability to control the nation’s deficit and high borrowing costs. Why are things spiraling now? Senior reporter Phil Aldrick joins this week’s In the City to explain. See omnystudio.com/listener for privacy information.

This week, we follow Brian Moynihan's tenure of "responsible leadership" at Bank of America and the network of regional presidents he has developed. We look at the role of AI in feeding the growing need for healthier snacks, and the intersection of geopolitics and economic risks in the coming year.See omnystudio.com/listener for privacy information.