Oncotarget

Listen to short summaries of the latest oncology-focused research literature published in this week's issue of Oncotarget. https://www.oncotarget.com/archive/v12/i6/ Oncotarget Volume 12, Issue 6 features: COVER PAPER: "Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma." Institutions: Washington University in St. Louis, Columbia University, St. Louis Children’s Hospital, Siteman Cancer Center Quote: “We characterized genomic and neoantigen changes between 23 paired primary and recurrent HNSCC tumors. Twenty-three biopsies from patients originally diagnosed with locally advanced disease were identified from the Washington University tumor bank.” doi.org/10.18632/oncotarget.27907 EDITORIAL: "Innovating and expanding weight loss strategies for breast cancer survivors." Institution: Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Quote: “Compared to those with ideal body weight, women who have excess weight experience inferior outcomes once diagnosed with breast cancer, despite standard local and adjuvant therapy [6].” https://doi.org/10.18632/oncotarget.27898 RESEARCH PERSPECTIVE: "Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies." Institutions: The Johns Hopkins University School of Medicine, Dartmouth Geisel School of Medicine and Norris Cotton Cancer Center, Yale University, Stony Brook University Renaissance School of Medicine Quote: “Here, we review PDAC pathogenesis as it relates to fundamental ARS [Alternative RNA splicing] biology, with an extension to implications for PDAC patient clinical management.” doi.org/10.18632/oncotarget.27901 RESEARCH PAPER: "A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas." Institutions: Loma Linda University, University of Kansas Quote: “Herein we describe our search for small molecule inhibitors that disrupt binding of E6 to caspase 8 using AlphaScreen technology™ (Perkin Elmer, Waltham, MA). This technology is a proximity-based platform for identifying hit compounds that perturb a specific interaction between two beaded proteins. Using this approach, we interrogated a library of over 5000 small molecules for compounds that antagonize E6 binding to caspase 8.” doi.org/10.18632/oncotarget.27908 RESEARCH PAPER: "Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models." Institution: Ghent University Quote: “Here, we characterized the tumor microenvironment and the proportion and transcriptional profile of hepatic macrophages (Mφ) in two commonly used HCC mouse models.” doi.org/10.18632/oncotarget.27906 RESEARCH PAPER: "Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations." Institutions: Tata Memorial Centre, Homi Bhabha National Institute Quote: “We performed survival analyses of lung squamous cell carcinoma patients harboring therapeutically relevant alterations identified by whole exome sequencing and mass spectrometry-based validation across 430 lung squamous tumors.” doi.org/10.18632/oncotarget.27905 About Oncotarget: Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit www.oncotarget.com or follow us: SoundCloud - @oncotarget Facebook - www.facebook.com/Oncotarget/ Twitter - twitter.com/oncotarget LinkedIn - www.linkedin.com/company/oncotarget Instagram - www.instagram.com/oncotargetjrnl/ YouTube - www.youtube.com/OncotargetYouTube Pinterest - www.pinterest.com/oncotarget/ Reddit - www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105

Researchers conducted a study to understand why young Andean people are more affected by hepatocellular carcinoma.HCC in Andean people is different from the usual form, affecting adolescents. An integrative analysis of gene expression and DNA methylation was done on 74 Peruvian patients, revealing unique characteristics. The podcast delves into the molecular intricacies of Peruvian HCC and the importance of understanding genomic variances in diverse patient populations.

Exploring the benefits of precision oncology in advanced cancer treatment, focusing on improved survival rates and reduced healthcare costs. Study comparing targeted therapy guided by genomic testing with standard therapy shows superior survival outcomes and reduced costs.

Researchers discuss using machine learning to compare second-generation ALK inhibitors for treating NSCLC patients with positive gene rearrangements. They showcase the importance of treatment sequencing to maximize patient lifespan. Additionally, the podcast delves into the use of in-silico methods and Therapeutic Performance Mapping System to analyze drug mechanisms and evaluate the efficacy and safety profiles of ALK inhibitors.

Researchers evaluate CABYR isoforms a/b and c mRNA expression in colorectal cancer to identify potential vaccine targets. The podcast explores the use of Cancer testes antigens in cancer immunotherapies. A study compares the expression levels of cava isoforms in colorectal cancer tumor specimens versus normal colonic tissue.

Listen to short summaries of the latest oncology-focused research literature published in this week's issue of Oncotarget Volume 12, Issue 5. Click here for the complete issue: https://www.oncotarget.com/archive/v12/i5/ Oncotarget Volume 12, Issue 5 features: Cover Paper: "The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy." https://doi.org/10.18632/oncotarget.27897 Research Perspective: "Tumor mutational burden as a predictor of immunotherapy response in breast cancer." https://doi.org/10.18632/oncotarget.27877 Research Paper: "STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells." https://doi.org/10.18632/oncotarget.27884 Research Paper: "Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology." https://doi.org/10.18632/oncotarget.27894 Research Paper: "Mutational profile of skin lesions in hepatocellular carcinoma patients under tyrosine kinase inhibition: a repercussion of a wide-spectrum activity." https://doi.org/10.18632/oncotarget.27891 Research Paper: "Development of a ghrelin receptor inverse agonist for positron emission tomography." https://doi.org/10.18632/oncotarget.27895 Research Paper: "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry." https://doi.org/10.18632/oncotarget.27890 Research Paper: "Fine–mapping of two differentiated thyroid carcinoma susceptibility loci at 2q35 and 8p12 in Europeans, Melanesians and Polynesians." https://doi.org/10.18632/oncotarget.27888 Research Paper: "Quantitative proteome profiling stratifies fibroepithelial lesions of the breast." https://doi.org/10.18632/oncotarget.27889 About Oncotarget: Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit www.oncotarget.com or follow us: SoundCloud - @oncotarget Facebook - www.facebook.com/Oncotarget/ Twitter - twitter.com/oncotarget LinkedIn - www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube Pinterest - www.pinterest.com/oncotarget/ Reddit - www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105

Researchers Dr. Beatrice Aramini and Dr. Valentina Masciale discuss their review paper on the crosstalk between cancer stem cells and macrophages, highlighting potential anti-cancer strategies. They delve into the role of cancer stem cells in tumor progression and the relationship between cancer stem cells and tumor-associated macrophages in the tumor microenvironment.

The podcast discusses the convenience and accessibility of scientific research through author interviews, readings, and press releases of research papers, making it easy to stay updated on oncology-focused studies. It also explores how the post-publication service enhances the reach of authors' research and aligns with open access initiatives.

Dr. Mikhail V. Blagosklonny discusses using clinically approved drugs to extend lifespan by inhibiting signaling pathways, emphasizing the importance of combination therapy for optimal results in geroscience.

The podcast discusses the improved efficacy of anti-tumor antibodies when combined with immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma, leading to significant reduction of solid tumors and lung metastases. The authors highlight the benefits of enhancing anti-tumor responses through combination therapy and immune checkpoint blockade for better therapeutic outcomes in cancer treatment.