Oncotarget

Researchers explore new potential biomarkers in sarcomas, highlighting the Hippo pathway, RABL6A, and p53-MDM2 axes. The need for improved prognostic and therapeutic markers is discussed. Protein expression analysis, survival predictions, and network analysis of key proteins are examined, revealing promising insights for future research and therapeutic opportunities.

Listen to short summaries of the latest oncology-focused research published in this week's issue of Oncotarget. https://www.oncotarget.com/archive/v12/i8/ Oncotarget Volume 12, Issue 8 features: COVER PAPER: “Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas” https://doi.org/10.18632/oncotarget.27928 NEWS: “Immunotherapy and fatigue: what we know and what we don’t know” https://doi.org/10.18632/oncotarget.27946 (PDF Download) EDITORIAL: “Drug exposure: still relevant after all these years” https://doi.org/10.18632/oncotarget.27899 (PDF Download) EDITORIAL: “Up to your NEK2 in CIN” https://doi.org/10.18632/oncotarget.27918 (PDF Download) RESEARCH PAPER: “Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra®” https://doi.org/10.18632/oncotarget.27945 RESEARCH PAPER: “Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib” https://doi.org/10.18632/oncotarget.27924 RESEARCH PAPER: “Controlling for cellular heterogeneity using single-cell deconvolution of gene expression reveals novel markers of colorectal tumors exhibiting microsatellite instability” https://doi.org/10.18632/oncotarget.27935 RESEARCH PAPER: “Urine protein biomarkers of bladder cancer arising from 16-plex antibody-based screens” https://doi.org/10.18632/oncotarget.27941 RESEARCH PAPER: “The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations” https://doi.org/10.18632/oncotarget.27943 RESEARCH PAPER: “Loss of CPAP causes sustained EGFR signaling and epithelial-mesenchymal transition in oral cancer” https://doi.org/10.18632/oncotarget.27932 RESEARCH PAPER: “Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth” https://doi.org/10.18632/oncotarget.27940 RESEARCH PAPER: “Predicting clinical outcomes using cancer progression associated signatures” https://doi.org/10.18632/oncotarget.27934 RESEARCH PAPER: “High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC” https://doi.org/10.18632/oncotarget.27930 About Oncotarget: Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com/ or follow us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/oncotargetyoutube Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget Oncotarget is published by Impact Journals , LLC. Please visit https://www.impactjournals.com/ or connect with us @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Delving into the disparity in thyroid cancer rates among different ethnic groups, researchers compare Vitamin D binding protein expression in Filipino Americans and European Americans. The study sheds light on the functional implications of DBP in various stages of thyroid cancer and its role in oncogenesis.

Learn about the development of the first blood test for early melanoma detection, using a signature of 10 autoantibodies with high sensitivity and specificity. Explore how this breakthrough research could revolutionize early diagnosis and decrease mortality rates in patients.

Researchers studied the metabolic effects of calorie restriction, tor1Δ mutation, and lithocholic acid in budding yeast. They compared the intracellular concentrations of 193 metabolites, revealing unique metabolic patterns induced by different geroprotective interventions.

The podcast discusses the AACR Annual Meeting and highlights Oncotarget's prestigious position in oncology journals. It covers prominent authors and editorial board members associated with Oncotarget, as well as details on the 2021 AACR Conference and how Oncotarget contributes to disseminating scientific research.

Listen to short summaries of the latest oncology-focused research published in this week's issue of Oncotarget. https://www.oncotarget.com/archive/v12/i7/ Oncotarget Volume 12, Issue 7 features: COVER PAPER: "Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the metabolic design established by two other geroprotectors" https://doi.org/10.18632/oncotarget.27926 EDITORIAL: "The long road to TRAIL therapy: a TRAILshort detour" https://doi.org/10.18632/oncotarget.27902 RESEARCH PERSPECTIVE: "The role of immune surveillance in malignant transformation of benign salivary gland tumors" https://doi.org/10.18632/oncotarget.27900 RESEARCH PAPER: "Differential expression of Vitamin D binding protein in thyroid cancer health disparities" https://doi.org/10.18632/oncotarget.27920 RESEARCH PAPER: "Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine" https://doi.org/10.18632/oncotarget.27922 RESEARCH PAPER: "Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma" https://doi.org/10.18632/oncotarget.27915 RESEARCH PAPER: "Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1" https://doi.org/10.18632/oncotarget.27923 RESEARCH PAPER: "[18F]FDG and [18F]FES positron emission tomography for disease monitoring and assessment of anti-hormonal treatment eligibility in granulosa cell tumors of the ovary" https://doi.org/10.18632/oncotarget.27925 RESEARCH PAPER: "Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells" https://doi.org/10.18632/oncotarget.27910 RESEARCH PAPER: "Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients" https://doi.org/10.18632/oncotarget.27909 RESEARCH PAPER: "The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia" https://doi.org/10.18632/oncotarget.27921 CASE REPORT: "Prognostic significance of isochromosome 17q in hematologic malignancies" https://doi.org/10.18632/oncotarget.27914 About Oncotarget: Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com/ or follow us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/oncotargetyoutube Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget Oncotarget is published by Impact Journals , LLC. Please visit https://www.impactjournals.com/ or connect with us @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Exploring the distinctions between benign, borderline, and malignant breast tumors through proteomics. Highlighting potential prognostic markers and mechanisms driving progression from borderline to malignant states in fibroepithelial lesions.

Proteomic analysis reveals distinct clusters of fibroepithelial breast lesions, highlighting ECM remodeling and EMT markers. Candidate biomarkers MUCL1, HTRA1, and VEGDF show promise in differentiating FELs. Potential for improved diagnosis and disease management discussed by Dr. Lekha Dinesh Kumar and Dr. Prashant Kumar.

Researchers explore genomic and neoantigen evolution in head and neck tumors, focusing on primary vs. recurrent/metastatic samples. Study includes 23 patients with varying tumor locations and treatment histories. Findings highlight the impact of recurrent mutations and the potential for anti-tumor immune response based on neoantigens.