Oncotarget

Researchers from Yale University School of Medicine analyze DNA methylation and RNA expression profiles of uterine and soft tissue Leiomyosarcoma subtypes to identify biomarkers and therapeutic targets, highlighting epigenetic and transcriptomic differences. The study compares molecular landscapes using TCGA-SARC dataset and integrated analysis of clinically derived LMS samples, offering potential personalized treatment approaches based on distinct transcription signatures.

Listen to the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 16. https://www.oncotarget.com/archive/v12/i16/ Cover Paper - “Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma” https://doi.org/10.18632/oncotarget.28032 Research Paper - “High CD39 expression is associated with the non-muscle-invasive phenotype of human bladder cancer” https://doi.org/10.18632/oncotarget.28029 Research Paper - “MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways” https://doi.org/10.18632/oncotarget.28030 Review - “Genetic testing for homologous recombination repair (HRR) in metastatic castration-resistant prostate cancer (mCRPC): challenges and solutions” https://doi.org/10.18632/oncotarget.28015 Review - “Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death” https://doi.org/10.18632/oncotarget.28031 Editorial - “Mechanisms of resistance to mitochondria-targeted therapy in pancreatic cancer” https://doi.org/10.18632/oncotarget.7976 (PDF Download) Editorial - “Glucose starvation induces NADPH collapse and disulfide stress in SLC7A11high cancer cells” https://doi.org/10.18632/oncotarget.27993 (PDF Download) Editorial - “Tumor-reactive T cells are licensed by dendritic cells located in spatially different tissues: implications for dendritic cell vaccines” https://doi.org/10.18632/oncotarget.27972 (PDF Download) Keywords - leiomyosarcoma, epigenetics, DNA methylation, bladder cancer, pancreatic cancer, miRNA, prostate cancer, metastatic castration-resistant prostate cancer, apoptosis, glucose starvation, T cells, cancer, science, research, oncology About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com/ or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/oncotargetyoutube Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget Oncotarget is published by Impact Journals, LLC. Please visit https://www.impactjournals.com/ or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Explore the history and impact of the Ride for Roswell charity bike ride supporting cancer research. Learn about the Impact Journal's Peloton Team Open Access and innovative software in cancer treatment.

Exploring the significance of biomarkers in predicting treatment effectiveness for triple-negative breast cancer, focusing on markers like HER2 and hormone receptors. A study examines the impact of TROP2 expression and RAD51 in the effectiveness of treatment for TNBC, highlighting high TROP2 expression as a pivotal biomarker.

Discover how the novel E2F1-regulated lncRNA LAPAS1 impacts cell cycle progression and proliferation in human cancer cells. Inhibition of LAPAS1 leads to increased S phase cells, while knockdown of SPNS2 rescues LAPAS1 silencing effects. Dr. Doron Ginsberg explains the role of lncRNAs in regulating cell cycle progression, proliferation, and apoptosis.

Researchers explore the genomic effects of platinum compounds on telomeres in cancer cells, aiming to induce apoptosis. Terpyridine platinum compounds are investigated for their potential as oncotherapeutic agents in inducing chromosomal instability.

Listen to summaries of the latest oncology-focused research published in this week’s issue of Oncotarget, Volume 12, Issue 15. https://www.oncotarget.com/archive/v12/i15/ Cover Paper - “Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells” https://doi.org/10.18632/oncotarget.28020 Research Paper - “RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans” https://doi.org/10.18632/oncotarget.28024 Research Paper - “Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis” https://doi.org/10.18632/oncotarget.28011 Research Paper - “The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma” https://doi.org/10.18632/oncotarget.28025 Research Paper - “Identification of miR-203a, mir-10a, and miR-194 as predictors for risk of lymphovascular invasion in head and neck cancers” https://doi.org/10.18632/oncotarget.28022 Research Paper - “JunD accentuates arecoline-induced disruption of tight junctions and promotes epithelial-to-mesenchymal transition by association with NEAT1 lncRNA” https://doi.org/10.18632/oncotarget.28026 Research Paper - “Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase” https://doi.org/10.18632/oncotarget.28021 Editorial - “Multidisciplinary clinics in prostate cancer” https://doi.org/10.18632/oncotarget.27984 (PDF Download) Research Perspective - “Developing next generation immunomodulatory drugs and their combinations in multiple myeloma” https://doi.org/10.18632/oncotarget.27973 Keywords - chromosome instability, prostate cancer, sulforaphane, exosomes, head and neck cancer, miRNA, arecoline, biliary tract cancer, multiple myeloma, cancer, science, research, oncology About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com/ or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/oncotargetyoutube Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget Oncotarget is published by Impact Journals, LLC. Please visit https://www.impactjournals.com/ or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

The podcast discusses targeting tumor stem cell-associated carbohydrate antigens in ovarian cancer, highlighting the importance of novel treatment approaches. It explores the therapeutic potential of STN in ovarian cancer cells, showcasing the effectiveness of anti-STN antibody-drug conjugates in reducing cell viability and tumor volume in vitro and in vivo.

Oncotarget teams up with TrendMD to expand research reach and engage readers with recommended content based on viewing history and similar reader preferences. TrendMD's algorithm boosts research impact and increases paper citations by suggesting relevant content to interested audiences.

This podcast discusses the use of esomeprazole, typically used for acid reflux, as a radiosensitizer to improve tumor control. Researchers explore its anti-cancer effects in inhibiting cancer cell proliferation and enhancing radiation therapy.