Oncotarget

Researchers discuss the anticancer potential of CLK kinase inhibitors 1C8 and GPS167, revealing their impact on cancer cell proliferation, epithelial-mesenchymal transition, and antiviral immune response. Molecular mechanisms underlying the inhibitors' effects on processes critical for metastasis are explored.

Researchers Wesliany Everton Duarte, Jaqueline Diniz Pinho, Syomara Pereira da Costa Melo, and others discuss their study on Cyclin D1 expression in penile cancer patients, revealing significant correlations with clinical and histopathological features. The study surveyed 100 patients and highlighted the importance of further research in understanding the role of Cyclin D1 in penile cancer.

The podcast discusses Impact Journals' focus on cancer and aging research, highlighting Oncotarget as a leading journal in the field. It explores the efforts to connect different disciplines in oncology and biomedical sciences for better research outcomes.

Researchers Wafik S. El-Deiry and Shengliang Zhang discuss how the SARS-CoV-2 spike protein disrupts the p53 tumor suppressor pathway in cancer cells, potentially compromising its functions and increasing cancer cell viability. They highlight the need for further research to understand the implications of SARS-CoV-2 infection on cancer treatment outcomes.

Researchers Kevin C. Ma, Esther Mena, Liza Lindenberg, and others discuss their AI tool for producing PET images without CT scans, revolutionizing oncology patient imaging and reducing radiation exposure.

Researchers discuss how transfected SARS-CoV-2 spike DNA affects cancer cells' response to chemotherapy by interrupting p53-MDM2 interaction, suppressing p53 transcriptional activity, and inhibiting chemotherapy-induced activation of p21(WAF1) and TRAIL Death Receptor DR5.

The podcast discusses the Oncotarget sponsorship of the 19th International p53 Workshop in Italy, highlighting groundbreaking research on the TP53 gene in cancer. Distinguished speakers like Dr. Andre Gudkov, a collaborator with Oncotarget, contribute to advancing understanding of TP53 biology in oncology.

Exploring novel therapeutic bispecific antibodies for treating B-cell lymphoma by targeting IgM and other B-cell antigens. Discussing the challenges of antibody therapy due to the presence of soluble IgM in the blood and how bispecific antibodies can address this issue.

Exploring synergistic drug combinations targeting AML cells to enhance cytotoxic effects and overcome drug-resistance mechanisms. Research study shows promising results with ABT199 and Thyotepa, revealing enhanced apoptosis activation, DNA damage response, stress signaling, and reduced drug resistance markers. Potential for improved therapies for AML patients.

Exploring the role of MIA-602 in overcoming Doxorubicin-resistance in Acute Myeloid Leukemia, researchers examined the impact of MIA-602 on Doxorubicin-resistant AML cell lines. In vitro results revealed a significant reduction in cell viability for all treated cells, indicating potential alternative treatment for AML and drug-resistant AML with GHRH antagonists.