In this episode Professor Harries addresses some of the fundamental questions about RNA splicing and how it regulates gene expression Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease. She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview. Professor Harries site at University of Exeter https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries Senisca home page https://www.senisca.com/ If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Professor Robbins discusses reprogramming using the Yamanaka Factors as the most promising technology in aging and its relationship to DNA damage. He also talks about his personal protocol for longevity. Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Professor Robbins discusses the work his lab is doing with Exosomes or EV (Extra-Cellular Vesicles) and how these can impact senescent cells by suppressing SASP as senomorphics Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Professor Robbins discusses the work his lab is doing, investigate what makes centenarians different at the genetic level and then to develop drugs which can mimic these differences. One of these differences is in SIRT6 and he talks about what they are doing to better understand this in collaboration with Prof Vera Gorbunova and colleagues at the Albert Einstein College of Medicine. Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Professor Robbins discusses the process by which his and other labs look for possible senolytics. He also talks about fisetin and why he chooses to take it Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Professor Robbins discusses cellular senescence in general then dives into cellular senescence in the immune system. As immune cells are present through out the body, embedded in different tissues, their senescence has the ability to impact the system in ways that other senescent cells may not. Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Professor Robbins discusses his theory of aging, the Unitary Theory of Fundamental Aging and how that helped his choice to work on aging rather than specific diseases. Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota. He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials. Professor Robbins' page at University of Minnesota https://robbins.umn.edu/dr-paul-robbins-phd Institute of the Biology of Aging and Metabolism If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Dr Gundry talks about his theory of aging (which involves the gut and mitochondria of course!) and also his longevity protocol. Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview. The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page. https://drgundry.com/ Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7) https://amzn.to/3ID7pi4 If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Dr Gundry discusses other ways of encouraging mitochondrial uncoupling, particularly in brown fat. He also covers thermogenic compounds, like ginger and tumeric and why they make you feel hot. Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview. The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page. https://drgundry.com/ Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7) https://amzn.to/3ID7pi4 If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/

In this video Dr Gundry discusses the top three supplements for healthy aging and also melatonin as a mitochondrial anti-oxidant Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview. The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page. https://drgundry.com/ Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7) https://amzn.to/3ID7pi4 If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan 15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15. Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/ 10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/