Melvyn Bragg and guests delve into the implications of ageing, with a focus on economic factors and longevity. They discuss debunking myths around ageing, theories on longevity, and the impact of science on extending health span. The conversation also touches on the global impact of ageing on societies, including political influences and challenges faced by different regions.

Melvyn Bragg and guests discuss the implications of the developments in genetic engineering. Out of the city of Cambridge in the mid century came DNA and out of Edinburgh at the end of the century came the cloning of Dolly the sheep. These two facts might well do more to change the world literally, and our view of the world, than anything else that has happened at any time. Genetics have become the conversation of our day and with the Human Genome Project lumbering towards completion, its power grows. But are the consequences likely to be destructive and will what we think of as a human being, a personality, or even a person, change uncomfortably and irredeemably? With Grahame Bulfield, geneticist, honorary professor, Edinburgh University and Director of the Roslin Institute, Edinburgh; Bryan Appleyard, features writer for The Sunday Times and author of Brave New Worlds: Genetics and the Human Experience.

Melvyn Bragg and guests marvel at our brains and discuss how at the end of a century of research we still understand so little about how they work.Developments in the understanding of the brain represent one of the major leaps forward in science in the 20th century, and the research is gathering pace and intensity. It’s a subject which captures the imagination, particularly the search for consciousness whatever that might be, and brings together some of the newest technology and the oldest belief systems. What a piece of work is the brain - a grain-of-sand-sized piece contains one hundred thousand neurons, two-million axons and one billion synapses which all talk to each other. How far we have got with our understanding of the brain and what can it tell us about ourselves and the world we live in?With Professor Susan Greenfield, director of the Royal Institution, Professor of Pharmacology, Oxford University and Professor of Physics at Gresham College; Professor Vilayanur Ramachandran, Professor of Neuroscience and Psychology, Director of the Brain Perception Laboratory, University of California in San Diego and Professor at the Salk Institute.

Melvyn Bragg and guests discuss how our increased knowledge of the functioning of the brain and the mechanisms of memory in the 20th century has changed our feelings about our own natures, and our approach to the behaviour and treatment of others.Many questions have been thrown up this century by our growing knowledge about how the brain and the mind function. How easy is it to establish the relationship between the two, and what light can this relationship throw on our understanding of our own and others natures? With Steven Rose, Professor of Biology and Director of the Brain and Behaviour Research Group, Open University, Dan Robinson, Distinguished Research Professor, Georgetown University and visiting lecturer in Philosophy and Senior Member of Linacre College, Oxford University.

Melvyn Bragg and guests discuss how perceptions of science and the power of science have changed in the 20th century. Does scientific endeavour increasingly concern itself with doubt rather than certainty, and is it coming any closer to integrating with other disciplines - philosophy or the social sciences? How much does the scientific explanation of the world owe to a wish for coherent understanding we all have, rather than objective observation, and why are we alternately disapproving of, then obsessively over-enthusiastic about new scientific theories? How far has specialisation in the sciences obscured our view of the world in its entirety, and if scientists want to operate within a social framework, can they do so and still claim to be objective and value-free in their findings?With John Gribbin, Visiting Fellow in Astronomy, University of Sussex and consultant to New Scientist; Mary Midgley, moral philosopher and former Senior Lecturer in Philosophy, University of Newcastle.

Melvyn Bragg and guests discuss whether the mass of scientific understanding and knowledge we have accumulated has destroyed our sense of poetic wonder at the world. Has our sense of awe at how the world works obscured our desire to know why it works the way it does? With Richard Dawkins evolutionary biologist, reader in Zoology and Fellow of New College, Oxford, Charles Simonyi Chair of Public Understanding of Science, Oxford University and author of Unweaving The Rainbow: Science, Delusion and The Appetite For Wonder; Ian McEwan, novelist, and author of the Booker prize winning novel Amsterdam.