Neurology® Podcast

1. Featured Article: Dual antiplatelet therapy pretreatment in intravenous thrombolysis for acute ischemic stroke2. What's Trending: Recurrent glioblastoma treated with recombinant poliovirusDr. Dan Ackerman talks with Dr. Andrei Alexandrov about his paper on dual antiplatelet therapy pretreatment. In the second part of the podcast, Dr. Kait Nevel focuses her interview with Dr. Darrell Bigner on treatment for recurrent glioblastoma. DISCLOSURES: Dr. Alexandrov has served on a scientific advisory board and consulted for Cerevast Therapeutics, Inc.; has served on editorial boards for Cerebrovascular Diseases and Interventional Neurology; holds a patent, and receives associated license fee and royalty payments, for "Therapeutic Methods and Apparatus for Use of Sonication to Enhance Perfusion of Tissue" (US patent 6,733,450 - May 11, 2004); receives publishing royalties for Cerebrovascular Ultrasound in Stroke Prevention and Treatment (Futura / Blackwell Publishing. 2003.), Cerebrovascular Ultrasound in Stroke Prevention and Treatment (Oxford: Blackwell Publishing (in Chinese) 2007), Cerebrovascular Ultrasound in Stroke Prevention and Treatment (2nd Edition) (Oxford: Wiley-Blackwell Publishers. 2011); has served on speakers' bureau for Genentech, Inc.; has received research support from Cerevast Therapeutics, Inc. and NINR (R01 pending); holds stock or stock options in Cerevast Therapeutics, Inc.; receives Board of Reagents compensation from Cerevast Therapeutics, Inc.; and serves as President-Elect for the American Society of Neuroimaging. All other participants report no disclosures.

1. Practice guideline recommendations summary: Disorders of consciousness2. Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human HerpesvirusIn the first segment, Dr. Jeff Burns talks with Dr. Joseph Giacino about the AAN Guideline update on disorders of consciousness. In the second part of the podcast, we are featuring a discussion with Dr. Jason Crowell and Dr. Joel Dudley discuss the detection of human herpesvirus genes in in a large cohort patients with Alzheimer disease.DISCLOSURES: Dr. Burns has served on the DSMB for NIH-funded trials (non-profit entities); serves on the editorial board for Journal of Alzheimer's Disease; has consulted for Grifols, USA; has served on Eli Lilly Amyvid Speaker's Bureau; and has received research support from Eli Lilly, Avid Radiopharmaceuticals, Toyama Chemical Company, Merck, Biogen, AbbVie, Novartis, vTv Therapeutics, Janssen, and NIH (R01AG058557, R01AG053312, R01AG034614, R01AG03367, R01AG043962, P30AG035982, U10NS077356, UL1TR000001). Dr. Giacino has served on the scientific advisory board for the Traumatic Brain Injury Model Systems National Data and Statistical Center (federal agency); serves on the editorial board for Journal of Head Trauma Rehabilitation; serves as Director of the Spaulding Rehabilitation Network Disorders of Consciousness Program; has received research support from the U.S. Department of Defense, (Co-Investigator, W81XWH-11- 2-0210; Co-Investigator, W81XWH- 08-2-0159; Co-PI, W81XWH-14-2-0176), National Institute on Disability and Rehabilitation Research, (PI, H133A120085; site PI, 90DP0060; PI 4, 90DPTB0011), National Institutes of Health (Co-PI, 1U01NS086090-01; Co-PI, UH3NS095554), James S. McDonnell Foundation, and the The Barbara Epstein Foundation, Inc; and served as expert witness in legal proceedings for DeCorato Cohen Sheehan & Federico. Dr. Crowell and Dr. Dudley report no disclosures.

For the September 2018 Delayed Recall episode, we are featuring recordings of in-person interviews that took place at the April 2018 AAN Annual Meeting. All interviewees were plenary speakers who gave talks throughout Annual Meeting week. These recordings originally appeared as "What's Trending" segments in July 2018 (July 17, 24, and 31, respectively). In the first interview, we will hear Dr. Alberto Espay speak with Dr. Jeff Lichtman about connectomics. Next, Dr. Stacey Clardy interviews Dr. Michael Wilson about his talk on next-generation sequencing and diagnosing meningitis and encephalitis. Last, Dr. Alberto Espay discusses the matter of who should be the primary caregivers for functional disorder patients with Dr. Andrea Leigh Haller and Dr. David Perez.

1. How Early Can We Diagnose Alzheimer's Disease (And Is It Sufficient)? 2. What's Trending: Updates to the International Classification of Headache Disorders (ICHD-3)Dr. Stacey Clardy talks with Dr. Ronald Petersen about his paper on Alzheimer disease diagnosis. In the second part of the podcast, Dr. Tesha Monteith focuses her interview with Dr. Jes Olesen on what's new in the 3rd edition of the International Classification of Headache Disorders (ICHD-3). The full ICHD-3 can be found at https://www.ichd-3.org/wp-content/uploads/2018/01/The-International-Classification-of-Headache-Disorders-3rd-Edition-2018.pdfDISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Petersen receives publishing royalties from Mild Cognitive Impairment (Oxford University Press, 2003); has consulted for Roche Incorporated, Merck, Genentech, Biogen, and GE Healthcare (presentation); and has received research support from the National Institute on Aging (U01-AG006786, P50-AG016574, U01-AG024904, U01 AG016976). Dr. Monteith serves as an editorial advisory board member for Neurology Now and receives research support from the NIH. Dr. Olesen has consulted for Jannsen Pharmaceutical Products and served on speakers' bureaus for Allergan.

1. Featured Article: Silent infarct is a risk factor for infarct recurrence in adults with sickle cell anemia2. What's Trending: Neuropalliative Care: Priorities to move the field forwardDr. Justin Sattin talks with Dr. Lori Jordan about her paper on silent infarct and the risk of infarct recurrence in adults with sickle cell anemia. In the second part of the podcast, Dr. Maisha Robinson focuses her interview with Dr. Claire Creutzfeldt on neuropalliative care.DISCLOSURES: Dr. Jordan serves on the editorial boards of the Journal of Child Neurology, Pediatric Neurology and Stroke; and has received research support from Dr. Creutzfeldt has received research support from NINDS (K23 NS099421-01A1) and Cambia Health Foundation's Sojourn Scholars Program. Dr. Sattin and Dr. Robinson reports no disclosures.

1. Neurology® Clinical Practice: Safety and efficacy of plasma exchange in pediatric transverse myelitis2. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA (POINT study)Dr. Stacey Clardy talks with Dr. Benjamin Greenberg about his paper on therapeutic plasma exchange in a cohort of pediatric transverse myelitis patients. Next, Will Rondeau interviews Dr. Clay Johnston about findings from the POINT study on clopidogrel and aspirin in acute ischemic stroke.DISCLOSURES:Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR).Dr. Greenberg has received travel funding from the Transverse Myelitis Association; has filed has filed patents on the use of antibody biology in multiple sclerosis; has consulted for Novartis, Alexion, and EMD Serono; and has received research support from Medimmune, Chugai, Medday, Genentech, NIH (RO1 NS071463), Unviersity of Texas Southwestern, Guthy Jackson Foundation, PCORI, Transverse Myelitis Association, and the National MS Society.Dr. Johnston has received travel reimbursements from the National Academies of Sciences, US News, Austin Chamber of Commerce, Johns Hopkins, UT Health Science Center, University of Utah Medical School, Medtronic, Astrazeneca, University of Rochester NY, and Duke University; has received research support from AstraZeneca, NIH/NCATS (UL1 RR024131), UCSF Clinical-Translational Science Institute, and NIH/NINDS (U01 NS062835-01A1, U01 NS062835).Mr. Rondeau reports no disclosures.

1. Diagnosing Cerebral Ischemia with Door-to-Thrombolysis Times Below 20 Minutes2. What's Trending: Tenecteplase versus Alteplase before Thrombectomy for Ischemic StrokeDr. Jimmy Berthaud speaks with Dr. Perttu Lindsberg about his paper on the accuracy and consequences of rapid stroke diagnostics in a neurological emergency department. In the second segment of the podcast, Dr. Kevin Barrett interviews Dr. Bruce Campbell about the EXTEND-IA TNK trial of tenecteplase for patients with ischemic stroke.DISCLOSURES: Dr. Berthaud reports no disclosures. Dr. Lindsberg serves as Assistant Editor for the medical journal DUODECIM; serves as chairman of the ad hoc committee on Current Therapy Guidelines in Stroke for the Finnish Medical Society; and has recieved research support for Helsinki University Hospital District, the Sigrid Jusélius Foundation, the Jane and Aatos Erkko Foundation, and the Signe and Ane Gyllenberg Foundation. Dr. Barrett has received research support from Axovant Sciences, Inc., the Virginia Center of Alzheimer's and Related Diseases, and the Department of Defense. Dr. Campbell serves on the editorial board for Stroke Stroke; served as PI of the EXTEND-IA trial, partially funded by unrestricted grant from Medtronic; and has received research support from the National Health and Medical Research Council of Australia (GNT1111972 2016-2019) and the Heart Foundation, Australia.

1. Organic solvents and MS susceptibility: Interaction with MS risk HLA genes 2. AAN 2018 Controversies in Neurology plenary: Andrea Leigh Haller and David Perez discuss primary caregivers for functional disorder patientsDr. Stacey Clardy talks with Dr. Anna Hedström about her paper on exposure to organic solvents and the associated risk of developing multiple sclerosis, followed by a discussion with Dr. Alberto Espay, Dr. Andrea Leigh Haller, and Dr. David Perez on who should be the primary caregivers for functional disorder patients. The second interview was originally recorded at the AAN Annual Meeting in Los Angeles.DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Drs. Hedström, Leigh Haller, and Perez report no disclosures. Dr. Espay serves as Associate Editor for the Journal of Clinical Movement Disorders; serves as an editorial board member of Parkinsonism and Related Disorders and The European Neurological Journal; serves on the scientific advisory board for Solvay Pharmaceuticals, Inc. (now Abbvie), Chelsea Therapeutics International, Ltd., Teva Pharmaceutical Industries Ltd., Impax, Merz Pharmaceuticals, Inc., Pfizer Inc, Solstice Neurosciences, Eli Lilly and Company, ACADIA Pharmaceuticals, Inc. and USWorldMeds; is a consultant for Chelsea Therapeutics International, Ltd., Solvay Pharmaceuticals, Inc. (now Abbvie), ACADIA Pharmaceuticals, Inc., Cynapsus and Lundbeck, Inc; receives royalties for publications of books from Lippincott, Williams & Wilkins and Cambridge University Press; serves on the speakers' bureau of UCB, Teva Pharmaceutical Industries Ltd., American Academy of Neurology and Movement Disorders Society; and receives research support from the CleveMed/Great Lake Neurotechnilogies, Michael J. Fox Foundation, and the NIH.

1. Non-invasive vagus nerve stimulation as acute therapy for migraine: The randomized PRESTO study2. AAN 2018 Hot Topics plenary: Michael Wilson discusses metagenomics for diagnosing CNS infectionsDr. Teshamae Monteith talks with Dr. Cristina Tassorelli about her paper on vagus nerve stimulation for treating migraine, followed by a discussion with Dr. Stacey Clardy and Dr. Michael Wilson on next-generation sequencing and diagnosing meningitis and encephalitis. The second interview was originally recorded at the AAN Annual Meeting in Los Angeles.DISCLOSURES: Dr. Monteith serves as an editorial advisory board member for Neurology Now and receives research support from the NIH. Dr. Tassorelli has served on scientific advisory boards for Allergan Inc., ElectroCore LLC, Eli-Lilly and Company, Novartis, Teva Pharmaceutical Industries Ltd; has received funding for travel or speaker honoraria from Novartis, Allergan Inc, and Teva Pharmaceutical Industries Ltd; serves on editorial boards for Journal of Headache and Pain and Frontiers in Neurology; has consulted for Allergan Inc. and Eli Lilly and Company; has received research support from Eli Lilly and Company, Novartis, Teva Pharmaceuticals, ElectroCore, and the Italian Ministry of Health; and serves as Chairman of the Committee for the Guidelines of Clinical Trials of the International Headache Society. Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Wilson has received research support from NIH/National Center of Advancing Translational Science (NCATS), Clinical and Translational Science Institute (CTSI), and the American Brain Foundation Clinical Research Training Fellowship.

This month's Delayed Recall episode consists of the Migraine Lesson of the Week series posted each week in January 2018. The episode starts with Dr. Teshamae Monteith's interview with Dr. Stephen Silberstein (January 9, 2018) about updates in chronic migraine risk factors and management, followed by her interview with Dr. Jelena Pavlovic (January 16, 2018) on the interplay between migraine and hormones. Next, Dr. Monteith focuses her interview with Dr. Stuart Tepper on neuromodulation (January 23, 2018). In the fourth and final interview, Dr. Monteith and Dr. Benjamin Friedman discuss emergency management of migraine (January 30, 2018).