Neurology® Podcast

Drs. Jacqueline French and Nora Jandhyala discuss challenges in identifying non-motor seizures in adolescents with focal epilepsy, highlighting missed diagnostic opportunities and the importance of early intervention. They explore risks of missed diagnoses, injuries, and lack of specialist referrals, emphasizing the need for improved emergency department protocols. The significance of non-motor symptoms in first-time seizures is also emphasized, advocating for timely diagnosis and management to prevent tragic consequences.

The May 2024 replay features four episodes on neuro-oncology for brain cancer awareness month. The episode begins with Dr. Philipp Karschnia discussing the assessment of whether MTHFR polymorphisms affect the risk for leukoencephalopathy. The episode continues with Dr. Ingo Mellinghoff discussing new treatment opinions for isocitrate dehydrogenase (IDH)–mutant grade 2 gliomas. The third interview leads into a conversation with Dr. Linda Liau on the study of vaccine-based therapy for GBM. The episode concludes with Dr. Teddy Totimeh talking about brain tumor programs in Asia and Africa. Podcast Links: MTHFR Polymorphisms and Leukoencephalopathy Risk in CNS Lymphoma Patients New Treatment for IDH mt Gliomas Study of Vaccine-Based Therapy for GBM Brain Tumor Programs in Asia and Africa Article Links: https://doi.org/10.1212/WNL.0000000000207670 https://www.nejm.org/doi/full/10.1056/NEJMoa2304194 https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847 https://doi.org/10.1016/j.wneu.2023.04.067 Disclosures can be found at Neurology.org.

Dr. Justin Abbatemarco talks with Dr. Bob Fox about the relationship between serum neurofilament light chain (sNfL) levels and radiologic multiple sclerosis disease activity. Read the related article in Neurology. Disclosures can be found at Neurology.org.

Dr. Ellen Iacobaeus discusses late-onset MS in Swedish patients, highlighting differences with adult-onset MS like higher disability levels and less inflammation. She explores challenges in therapy, prescribing patterns, and managing late-onset MS patients, emphasizing the need for tailored treatment and vigilant monitoring.

Dr. Chris Gibbons discusses using skin biopsies to detect phosphorylated α-synuclein in Parkinson's disease and other synucleinopathies, highlighting high sensitivity and specificity rates. They explore the role of skin biopsies in predicting and diagnosing neurodegenerative diseases, emphasizing the clinical utility in treatment decisions.

As part of our "Physician as Patient" series, Dr. Andy Southerland talks with Dr. Amy Hessler about her experience with a ruptured arteriovenous malformation as a 2nd-year neurology resident. Disclosures can be found at Neurology.org.

As part of our "Physician as Patient" series, Dr. Andy Southerland talks with Dr. Joe Sirven about his experience with a ruptured arteriovenous malformation. If you're attending the AAN Annual Meeting in Denver, you can catch this conversation and more in a live Q&A session on April 16th at 2:30 pm MT at the publication stage. Disclosures can be found at Neurology.org.

Dr. Jeff Ratliff talks with Drs. Dara V. F. Albert and Afsaneh Talai about understanding the gaps in resident education on psychogenic nonepileptic seizures. Read the related article in Neurology: Education. Disclosures can be found at Neurology.org.

Dr. Elizabeth Gerstner discusses the use of CAR-T cells in treating glioblastoma, targeting specific genetic markers like EGFR-V3. She explains the challenges of recurrence, outcomes, and potential impact on improving treatment efficacy by targeting the tumor microenvironment. The podcast addresses the limited eligibility and need for further research before broader implementation in patient care.

Dr. Justin Abbatemarco talks with Dr. Géraldine Androdias about the impact of immune checkpoint inhibitors on the course of multiple sclerosis. Read the related article in Neurology: Neuroimmunology and Neuroinflammation. Disclosures can be found at Neurology.org.