Neurology® Podcast
Clinical Characteristics and Long-Term Outcomes of Late-Onset MS
Apr 25, 2024
Dr. Ellen Iacobaeus discusses late-onset MS in Swedish patients, highlighting differences with adult-onset MS like higher disability levels and less inflammation. She explores challenges in therapy, prescribing patterns, and managing late-onset MS patients, emphasizing the need for tailored treatment and vigilant monitoring.
19:58
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Quick takeaways
- Late-onset MS patients have faster disability progression compared to adult-onset MS.
- Prescription rates of high-efficacy DMT are lower in late-onset MS patients.
Deep dives
Characterizing Late-Onset Multiple Sclerosis
The study aimed to characterize patients with late-onset multiple sclerosis (MS) with symptom onset after 50 years, termed late-onset MS (LOMS). Through a cohort of approximately 9,000 MS patients in Sweden, it was found that 12% were LOMS. LOMS was associated with a more unfavorable disease course compared to adult-onset MS, showing faster disability progression and higher levels of disability at presentation.
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