Neurology® Podcast

In the first part of this special three-part series, Dr. Stacey Clardy talks with Drs. Elisabeth Bik and Matthew Schrag about critical issues surrounding research integrity and misconduct. Read the related article in Undark. Disclosures can be found at Neurology.org.

Dr. Farrah Mateen talks with Dr. Katrin Seeher about the significant global burden of neurologic conditions, which affects over 3.4 billion people worldwide, and the strategies the WHO is implementing to improve care and awareness. Read the related article in The Lancet Neurology. Disclosures can be found at Neurology.org.

Dr. Colin Hoy, an expert in prodromal Parkinson's disease, tackles ethical considerations on early diagnosis. Dr. Chris Gibbons sheds light on the innovative use of skin biopsies to detect phosphorylated α-synuclein, showcasing its high sensitivity. Drs. Michiko K. Bruno and Lawrence Golbe discuss practical algorithms for diagnosing atypical parkinsonism, emphasizing the importance of personalized approaches and comprehensive training for healthcare professionals. This conversation navigates the complexities of diagnosis and the promising advancements in neurodegenerative disorder detection.

Dr. Nanditha Rajamani, a researcher specializing in deep brain stimulation, and Dr. Andy Horn, a neurology innovator, dive into the transformative potential of personalized DBS therapy for Parkinson's disease. They discuss cutting-edge advancements, such as tailoring treatments to specific symptom pathways and utilizing modern imaging for precise electrode placement. The conversation highlights the development of the ClearN algorithm to optimize outcomes and emphasizes how data-driven approaches can revolutionize symptom management and enhance patient care.

Dr. Shuvro Roy, a clinician specializing in small-fiber neuropathy management, teams up with Dr. Anne Louise Oaklander, an authority in the field, to discuss vital insights for clinicians. They delve into the diagnostic challenges of relapsing-remitting small fiber neuropathy through a decade-long patient case. The duo also emphasizes the importance of longitudinal studies in improving diagnoses and the creation of a symptom survey to enhance understanding of SFN. Their exploration of treatment complexities during pregnancy adds an intriguing layer to the conversation.

Dr. Dara Albert talks with Dr. Jaclyn M. Martindale about the differences in gender representation among leadership positions and award recipients within the Child Neurology Society. Read the related article in Neurology®. Disclosures can be found at Neurology.org.

Dr. Lawrence Golbe, a prominent figure at Rutgers Robert Wood Johnson Medical School, joins Dr. Jeff Ratliff and Dr. Michiko K. Bruno to discuss a practical diagnostic algorithm aimed at identifying atypical parkinsonian disorders. They explore the significant challenges of diagnosing these disorders due to symptom overlap and the lack of biomarkers. Key topics include the role of MRI in diagnosis, the need for thorough evaluations, and strategies for assessing levodopa responses, all crucial for improving patient care and outcomes.

Dr. Gordon Smith, an expert on critical illness myopathy, joins researchers Dr. Shahar Shelly, who focuses on CMAP duration, and Dr. Teerin Liewluck, who studies myosin loss's impact on mortality. They delve into the vital link between CMAP duration and myosin loss, revealing surprising correlations. The discussion highlights the intricate relationship between muscle weakness, neuropathy, and the challenges in ICU care. Additionally, they emphasize personalized treatment strategies for patients facing these conditions and the importance of accurate diagnosis.

Dr. Tesha Monteith, an expert on PACAP biology, joins Dr. Messoud Ashina, a specialist in migraine therapies, to discuss groundbreaking research on monoclonal antibodies for migraine prevention. They dive into PACAP's crucial role in migraine development and the challenges of treatment research. The conversation includes insights from recent clinical trials assessing the effectiveness of PACAP-targeted therapies, the potential for combination treatments, and the future of migraine management. An engaging exploration of a promising new frontier in headache treatment!

Dr. Amy Gelfand, an expert on the glymphatic system, joins Dr. Matthew Bender, a specialist in intracranial hypertension, to explore the links between glymphatic outflow and transverse sinus stenosis. They discuss how glymphatic dysfunction may worsen idiopathic intracranial hypertension, the role of diffusion tensor imaging in brain fluid dynamics, and the implications of obesity in this condition. The conversation also touches on treatment strategies, including GLP-1 receptor agonists and venous sinus stenting.