The Clinical Problem Solvers

Kassidy Lovins, a third‑year med student who presented the case, and Dr. Ann Marie Kumfer, a cardiologist and clinical educator, walk through a 35‑year‑old with fevers, diffuse myalgias, and profound weakness. They explore infection versus inflammatory causes, evolving cardiac findings with pericardial effusion and purulent pericarditis, and the diagnostic clues that reveal an underlying immunodeficiency.

Shantanu Rai, a primary care physician and author of the novel A Dangerous Diagnosis, presents a clinical case adapted from his book. The conversation covers a four-month fever with weight loss, dramatic labs like very high ferritin and LDH, and the diagnostic reasoning that refocused the case. He also explains why he wrote a medical thriller and the storytelling behind clinical puzzles.

In this discussion, Greg Kirshen, a second-year maternal-fetal medicine fellow with a knack for diagnostic reasoning, presents a case of a 30-year-old man suffering from complex pelvic and joint pain following a COVID infection. The conversation dives deep into distinguishing neurological versus rheumatological causes for mixed symptoms. They unravel clues from physical exams and lab results, explore the implications of seronegative spondyloarthropathy, and discuss the significance of imaging for accurate diagnosis. A riveting look at post-COVID complications!

Dive into the fascinating case of a 73-year-old woman grappling with dyspnea, where hosts unravel the dyspnea pyramid and key triage questions. Explore intriguing ED findings like AFib and elevated lactate levels. The discussion delves into the causes of anemia and reveals a surprising EGD finding—gastric antral vascular ectasia (GAVE). Connections emerge between GAVE and systemic sclerosis, with insights on Raynaud's and antibody testing. A blend of complex medical concepts and engaging dialogue keeps listeners captivated throughout!

In this enlightening discussion, Andrew Sanchez, a hospitalist-educator, presents a perplexing case of bilateral leg weakness while Aaron Berkowitz, a neurologist, guides the analysis through differential diagnoses. Sarah K Blaine, an aspiring neurologist, joins the conversation, exploring the nuances of spinal versus peripheral causes and the significance of symptoms like weight loss and atrophy. The group delves into diagnostic strategies, discussing the implications of lab results and imaging in pursuit of clarity amidst uncertainty.

A 65-year-old woman with fatigue presents an intriguing clinical puzzle for discussion. Hosts dive into differential diagnoses, exploring causes of tachycardia and hypokalemia. They emphasize the importance of magnesium levels and blood gas analyses to clarify metabolic acidosis. A surprising twist reveals ketosis despite a normal anion gap, leading to insights on renal function. The conversation explores fascinating mechanisms of non-gap acidosis and highlights the value of curiosity in clinical casework, showcasing learning from ordinary yet complex cases.

https://clinicalproblemsolving.com/wp-content/uploads/2026/01/CUS-1-2026.wav Ring in the New Year with a fresh episode!Join Debora, Mark, and Noah in the latest Clinical Unknown Series as they unravel a puzzling case together.Let’s start the year learning! To join us live on Virtual Morning Report (VMR), sign up HERE.Download CPSolvers App hereRLRCPSOLVERS

Dive into a clinical neurology case that explores a patient with weakness and numbness. The hosts discuss how to localize neurologic deficits while weighing differential diagnoses like stroke and peripheral neuropathy. Urgent imaging priorities and management steps are debated as new findings evolve the case. They wrap up with teaching pearls for honing neuro localization skills. Join them on this enlightening journey to confront neurophobia and enhance diagnostic reasoning.

A captivating case of eosinophilia unfolds as the hosts discuss a 50-year-old woman presenting with rapid weight gain and edema. They explore various organ-based causes, analyzing low blood pressure's significance. The narrative dives into lab findings, highlighting marked eosinophilia and hypoalbuminemia. Discussion around possible GI causes, medication history, and a critical bone marrow biopsy reveals key insights. The diagnosis of a checkpoint inhibitor-associated reaction leads to a successful treatment response, turning a diagnostic puzzle into a medical victory.

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