The Clinical Problem Solvers

https://clinicalproblemsolving.com/wp-content/uploads/2026/01/CUS-1-2026.wav Ring in the New Year with a fresh episode!Join Debora, Mark, and Noah in the latest Clinical Unknown Series as they unravel a puzzling case together.Let’s start the year learning! To join us live on Virtual Morning Report (VMR), sign up HERE.Download CPSolvers App hereRLRCPSOLVERS

Dive into a clinical neurology case that explores a patient with weakness and numbness. The hosts discuss how to localize neurologic deficits while weighing differential diagnoses like stroke and peripheral neuropathy. Urgent imaging priorities and management steps are debated as new findings evolve the case. They wrap up with teaching pearls for honing neuro localization skills. Join them on this enlightening journey to confront neurophobia and enhance diagnostic reasoning.

A captivating case of eosinophilia unfolds as the hosts discuss a 50-year-old woman presenting with rapid weight gain and edema. They explore various organ-based causes, analyzing low blood pressure's significance. The narrative dives into lab findings, highlighting marked eosinophilia and hypoalbuminemia. Discussion around possible GI causes, medication history, and a critical bone marrow biopsy reveals key insights. The diagnosis of a checkpoint inhibitor-associated reaction leads to a successful treatment response, turning a diagnostic puzzle into a medical victory.

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Explore a compelling case of a 39-year-old woman suffering from subacute abdominal pain and vomiting. The discussion delves into the nuances of abdominal pain history-taking and the importance of recognizing systemic clues. A differential diagnosis unfolds, highlighting infections, malignancies, and autoimmune diseases. The team's diagnostic journey includes targeted lab tests and imaging that reveal significant findings. Ultimately, they narrow down to hepatic sarcoidosis and discuss treatment strategies, showcasing the intricacies of clinical reasoning.

Anmolpreet Kaur, a clinician specializing in diagnostic reasoning, joins Mark for an engaging case discussion. They tackle a complex scenario involving a 71-year-old patient with altered mental status and delve into the MIST framework for diagnostics. Highlights include the importance of time course in symptoms, managing severe electrolyte imbalances, and interpreting symptoms tied to pneumonia and brain conditions. The conversation culminates in diagnosing glioblastoma and an MRSA lung abscess, illustrating the intricate connections within complex medical cases.

Dr. Ann Marie Kumfer, a North Carolina hospitalist, and Dr. Kuchal Agadi, an internal medicine resident, delve into a complex case of a ventilated young man suffering from fever and empyema. Ann Marie shares insights on assessing infection sources in nonverbal patients, while Kuchal presents alarming lab results such as severe anemia and loculated effusion. The duo discusses the challenges of antibiotic stewardship and the importance of timely drainage in empyema management, revealing final microbiology findings like Achromobacter and Pseudomonas.

Hosts exchange humorous anecdotes and dive into a fascinating clinical case involving a patient with a forehead mass. They discuss the diagnostic process, revealing CT findings that suggest osteomyelitis. The conversation shifts to exploring potential infectious causes, highlighting the importance of thorough testing. The surprising diagnosis of secondary syphilis as the culprit for skull osteomyelitis underlines the need for clinical reasoning in rare cases. A mix of levity and serious medical insight makes for an engaging discussion.

Dr. Yousuf Patel, a neurology resident from Cape Town with diverse medical training, presents a compelling case of diplopia and fever. He dives into distinguishing types of diplopia and the crucial role of the medial longitudinal fasciculus in gaze coordination. The discussion uncovers potential infectious causes linking fever with diplopia, addressing key diagnostic elements. A surprising link to Behçet's syndrome emerges through patient history and MRI findings, showcasing the importance of a thorough examination in uncovering complex neurological disorders.

A riveting case unfolds with a 65-year-old patient presenting severe dyspnea and anemia. The hosts dissect the diagnostic challenge of schistocytes and pinpoint their role in hemolysis. They navigate through critical lab findings and imaging, uncovering a potential malignancy linked to the patient's condition. Insights on the relationship between adenocarcinoma and hemolytic anemia provide a deeper understanding of marrow infiltration. The case culminates in a treatment response, emphasizing the importance of early diagnosis and lab sensitivity.