
The Clinical Problem Solvers
The Clinical Problem Solvers is a multi-modal venture that works to disseminate and democratize the stories and science of diagnostic reasoning
Twitter: @CPSolvers
Website: clinicalproblemsolving.com
Latest episodes

Jun 30, 2025 • 30min
Episode 404 – RLR – Gum Bleeding
A fascinating case of a patient with gum bleeding leads to a deep dive into differential diagnoses, including potential platelet disorders. The discussion highlights the intricacies of thrombocytopenia and anemia, exploring how underlying conditions like anal cell carcinoma can complicate symptoms. Listeners will appreciate the insights into interpreting lab results and the significance of the Immature Platelet Fraction. Key takeaways emphasize the importance of discerning between platelet and coagulation issues for effective patient management.

5 snips
Jun 24, 2025 • 29min
Episode 403: Schema Episode – Rhabdomyolysis
An intriguing case of atraumatic rhabdomyolysis sets the stage for a discussion on a 41-year-old man with acute leg weakness linked to substance use. The speakers delve into the complexities of diagnosis, emphasizing neurological examinations and the interplay between mental health and physical symptoms. Initial lab results reveal critical indicators, underscoring the importance of monitoring creatine kinase levels. The episode highlights treatment strategies and the serious implications of rhabdomyolysis, enriching the conversation with personal anecdotes and clinical insights.

5 snips
Jun 19, 2025 • 49min
Episode 402: Neurology VMR – AMS
In this engaging discussion, Bayan Al Zoabu, a passionate senior medical student from Syria known for her work in neurology and ethics, presents a case of a 71-year-old woman with altered mental status to Dr. Aye Chan Moe Thant, a dedicated neurologist focused on health equity. They dive into the complexities of diagnosing conditions like dementia and meningitis, the significance of lumbar punctures, and the essential role of thorough assessments in neurology. They also discuss the neurological implications of autoimmune disorders, revealing the intricacies of patient care.

Jun 17, 2025 • 41min
Episode 401 – #IDLove – Fever & AMS
In this engaging discussion, infectious disease expert Varun Phadke provides insight into a complex case involving a 50-year-old man with fever, altered mental status, and diarrhea. The conversation highlights the intricate link between gastrointestinal and neurological symptoms. Phadke tackles challenging diagnoses, including alcohol withdrawal and the intricacies of Legionella pneumonia. Listeners will appreciate the emphasis on detailed clinical reasoning and the importance of comprehensive evaluations in complex medical cases.

8 snips
Jun 6, 2025 • 40min
Episode 400: Clinical Unknown Series with Dr. Mengyu Zhou
In this engaging conversation with Dr. Mengyu Zhou, an IMG from China who now practices as a hospitalist in Oregon, listeners dive into complex clinical cases. The team tackles a 57-year-old woman suffering from constipation and confusion, navigating through diagnostic strategies and historical context. They also explore challenging conditions like Takayasu's arteritis and hypercalcemia with pancytopenia. By weaving personal stories into the mix, they emphasize the balance between life and medicine. It's a rich blend of clinical reasoning and human experience!

5 snips
Jun 2, 2025 • 44min
Episode – 399 – RLR – Ascites
The hosts share amusing pet anecdotes, setting a light conversational tone. They dive deep into ascites and chylous effusion, discussing fluid analysis methods. A case study features a 64-year-old man with bilateral hydronephrosis, exploring complex differential diagnoses. The critical evaluation of a chest x-ray reveals intriguing connections to heart and lymphatic issues. They also tackle a challenging case with idiopathic ureteral stenosis, highlighting the importance of teamwork and open dialogue among medical professionals.

May 29, 2025 • 47min
Episode 398: WDx #36: How to Approach a “Struggling” Learner
Dr. Julia Armendariz, a hospitalist and clinician educator at Stanford, shares her expertise on guiding struggling learners in medical education. She emphasizes the power of low-inference statements in feedback, helping to pinpoint underlying issues. The conversation highlights the need for empathy and clear communication, advocating for a compassionate approach. Julia also discusses the challenges of delivering feedback amidst emotional complexities, revealing strategies to support both high and low insight learners effectively.

35 snips
May 22, 2025 • 59min
Episode 397: Rafael Medina Subspecialty Episode – Hypertension in Pregnancy
Dr. Greg Kirschen, a Maternal-Fetal Medicine fellow at the Hospital of the University of Pennsylvania, and Dr. Mary Peeler, a fellow at UNC, dive deep into hypertension in pregnancy. They discuss a compelling case involving a pregnant woman with headaches and blurry vision, underscoring the risks of preeclampsia. Insights include essential lab tests for diagnosis, the significance of blood pressure control, and the protective role of medications like magnesium. The duo emphasizes addressing health disparities and the collaborative approach necessary for optimal patient care.

May 16, 2025 • 29min
Episode 396: Schema Episode – Hypercarbia
Andrew Sanchez, a clinical expert, shares a compelling case of a woman facing progressive dyspnea and hypercarbia. The discussion dives deep into obesity hypoventilation syndrome, evaluating the physiological factors leading to her respiratory distress. The team emphasizes the significance of thorough diagnostics, including the interpretation of chest X-rays. They also explore mixed respiratory failure exacerbated by heart failure, showcasing the critical connection between respiratory issues and obesity in treatment outcomes.

May 9, 2025 • 55min
Episode 395: Neurology VMR – Behavior change, headaches, and blurry vision
Aye Chan Moe Thant, a medical graduate from Myanmar, joins the discussion to present a challenging case of a 51-year-old woman with behavioral changes, headaches, and blurry vision. They delve into diagnosing complex neuroimmune disorders and explore potential diagnoses like hydrocephalus and encephalitis. The conversation highlights the role of environmental factors and intra-cranial pressure symptoms, emphasizing the importance of thorough clinical evaluations and imaging. Aye's commitment to health equity adds a powerful dimension to the medical intricacies discussed.