Evolution is a messy business, involving as it does selection pressures, mutations, genetic drift, and the effects of random external interventions. So in the end, how much of it is predictable, and how much is in the hands of chance? Today we’re thrilled to have as a guest my evil (but more respectable, by most measures) twin, the biologist Sean B. Carroll. Sean is both a leader of the modern evo-devo revolution, and a wonderful and diverse writer. We talk about the importance of randomness and unpredictability in life, from the evolution of species to the daily routine of every individual.Support Mindscape on Patreon.Sean B. Carroll received a Ph.D. in immunology from Tufts University. He is currently the Andrew and Mary Balo and Nicholas and Susan Simon Endowed Chair of Biology at the University of Maryland, Vice-President for Science Education at the Howard Hughes Medical Institute, the Executive Director of HHMI Tangled Bank Studios, and Professor Emeritus of Genetics and Molecular Biology at the University of Wisconsin. His new book, A Series of Fortunate Events: Chance and the Making of the Planet, Life, and You, explores the role of chance in the development of life.Web siteHHMI web pageGoogle Scholar publicationsTangled Bank StudiosTalk on The Serengeti RulesAmazon author pageWikipediaTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Teresa Bejan, political theorist, discusses free speech, civility, and toleration. They explore the complexities of civility and its dark side, the politicization of free speech, the distinction between Parisia and Isogaria, hate speech, the paradox of tolerance, Roger Williams' legacy of tolerance, de-platforming speakers at universities, seeking opposing views, and the cancel culture debate.

Netta Engelhardt discusses the black hole information puzzle, the role of wormholes in understanding it, and its implications for quantum gravity. They explore concepts such as black hole evaporation, entropy, and the second law of thermodynamics. They also discuss entanglement in quantum mechanics, the relationship between conformal field theory and anti-de Sitter space, and the search for an independent description of quantum gravity. They highlight recent progress in understanding the black hole information paradox and the concept of information conservation in black holes. The discussion delves into the gravitational path integral and its ability to reveal insights into information conservation.

Sexuality is, and always has been, a topic that is endlessly fascinating but also contentious. You might think that asexuality would be more straightforward, but you’d be wrong. Asexual people, or “aces,” haven’t been front and center in the public discussion of gender and sexuality, and as a result there is confusion about such basic issues as what “asexuality” even means. Angela Chen is a science journalist and an ace herself, and she’s written a new book about asexuality and how it fits into the wider discussion of sex and gender. Precisely because sexuality is so taken for granted by many people, thinking about asexuality not only helps us understand the issues confronting aces, but the meaning of sexuality more broadly.Support Mindscape on Patreon.Angela Chen received a B.A. in comparative literature from UC San Diego. She is a contributing editor at Catapult magazine, and her writings have appeared in The Wall Street Journal, Vox Media, The Atlantic, MIT Technology Review, and elsewhere. Her new book is Ace: What Asexuality Reveals about Desire, Society, and the Meaning of Sex.Web siteAmazon.com author pageTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You can’t always get what you want, as a wise person once said. But we do try, even when someone else wants the same thing. Our lives as people, and the evolution of other animals over time, are shaped by competition for scarce resources of various kinds. Game theory provides a natural framework for understanding strategies and behaviors in these competitive settings, and thus provides a lens with which to analyze evolution and human behavior, up to and including why racial or gender groups are consistently discriminated against in society. Cailin O’Connor is the author or two recent books on these issues: Games in the Philosophy of Biology and The Origins of Unfairness: Social Categories and Cultural Evolution.Support Mindscape on Patreon.Cailin O’Connor received her Ph.D. in Philosophy from the University of California, Irvine. She is currently Associate Professor of Logic and Philosophy of Science and a member of the Institute for Mathematical Behavioral Science at UCI. Her works involves questions in the philosophy of biology and behavioral science, game theory, agent-based modeling, social epistemology, decision theory, rational choice, and the spread of misinformation.Web siteGoogle Scholar publicationsPhilPeople ProfileTalk on how misinformation spreadsAmazon author pageTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Not too long ago nobody carried a mobile phone; now almost everybody does. That’s the kind of rate of rapid progress we’re seeing with our ability to directly edit genomes. With the use of CRISPR-Cas9 and other techniques, gene editing is becoming commonplace. How does that work — and perhaps more importantly, how are we going to put it to use? Fyodor Urnov has worked in this area from its beginning, having coined the term “gene editing.” We talk about how this new technology can be used to cure or prevent disease, as well as the pros and cons of designer babies.Support Mindscape on Patreon.Fyodor Urnov received his Ph.D. in Biology from Brown University. He is currently professor of Genetic, Genomics, and Development in the Department of Molecular and Cell Biology at UC Berkeley, as well as Director for Technology and Translation at the Innovative Genomics Institute. His research focuses on using CRISPR gene-editing techniques to develop treatments for sickle cell disease, radiation injury, and other conditions, as well as guiding IGI researchers as they bring these therapies from the lab to the clinic.Web pageGoogle Scholar publicationsInnovative Genomics InstituteTalk on “The Next Generation of Edited Humans”TwitterTodays episode is sponsored by The Great Courses Plus. Mindscape listeners get a free trial if they sign up at http://thegreatcoursesplus.com/mindscape.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Human civilization is only a few thousand years old (depending on how we count). So if civilization will ultimately last for millions of years, it could be considered surprising that we’ve found ourselves so early in history. Should we therefore predict that human civilization will probably disappear within a few thousand years? This “Doomsday Argument” shares a family resemblance to ideas used by many professional cosmologists to judge whether a model of the universe is natural or not. Philosopher Nick Bostrom is the world’s expert on these kinds of anthropic arguments. We talk through them, leading to the biggest doozy of them all: the idea that our perceived reality might be a computer simulation being run by enormously more powerful beings.Support Mindscape on Patreon.Nick Bostrom received his Ph.D. in philosophy from the London School of Economics. He also has bachelor’s degrees in philosophy, mathematics, logic, and artificial intelligence from the University of Gothenburg, an M.A. in philosophy and physics from the University of Stockholm, and an M.Sc. in computational neuroscience from King’s College London. He is currently a Professor of Applied Ethics at the University of Oxford, Director of the Oxford Future of Humanity Institute, and Director of the Oxford Martin Programme on the Impacts of Future Technology. He is the author of Anthropic Bias: Selection Effects in Science and Philosophy and Superintelligence: Paths, Dangers, Strategies.Web siteOxford web pageWikipediaAmazon author pageTalk on the Simulation ArgumentSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Neil Johnson, expert on complex systems, talks about the emergence of self-organization and the spread of disinformation through information networks. They explore the complexity of decision-making, game theory, and power laws. They discuss the sandpile avalanche problem and the parallels between support for ISIS and the far right. They also delve into the similarities between the spread of misinformation and physical viruses, and the challenges it poses on democracy and trust in science.

Jason Torchinsky, author and technology enthusiast, discusses the implications of self-driving cars and the potential changes they may bring. Topics include attitudes towards autonomous cars, limitations of artificial intelligence, the popularity of the trolley problem, and the design possibilities of autonomous vehicles.

Carl Bergstrom, a researcher studying information and disinformation in biology, joins the podcast to discuss the prevalence of bullshit in our world. He explores the flow of information in social networks, especially during the COVID-19 pandemic. They explore topics such as the challenges of misinformation on social media, the impact of data on persuasive arguments, and the divisive response to the pandemic. Bergstrom also discusses the importance of media literacy and regulating social media algorithms.