Fentanyl is killing at least seventy thousand Americans a year. It’s a synthetic drug, it’s up to 50 times more powerful than heroin and 100 times stronger than morphine. It’s also the biggest cause of death for Americans aged between 18 and 45: more than gun crime, more than road accidents. But where is that supply of Fentanyl to America coming from? And why are people taking it, when it’s so dangerous? And are there any solutions to this deadliest of epidemics? In today’s episode we speak to our Latin America correspondent, Guillermo Galdos, about the rare access he gained inside the Sinaloa cartel in Mexico, where he witnessed the mass production of Fentanyl. We also hear from journalist Ben Westhoff, who has spent years investigating the world of synthetic drugs in America and he explains why this crisis will get worse - even reaching the UK, before it gets better. Producer: Freya Pickford

70 years on from the last Coronation, when Britain was still an empire and hardly anyone had a TV - what does Charles the Third’s crowning say about us today and the Britain of the future? We know that the British do this type of pomp and ceremony better than anyone else, it defines who we are. But is that true?  You may be told this is all ancient, but many of the royal ceremonies we witness are actually made-up rituals from the Victorian era used to legitimise the monarchy in modern British life. Today we speak to the historian, Sir David Cannadine, an expert on modern British history who sat on the coronation committee, about how we got to this place of flamboyant royal symbolism - and what this modern coronation tells us about where we are today. Sources: AP Producer: Freya Pickford

The US Vice President Kamala Harris recently went on tour to Tanzania, Ghana and Zambia. But she was not the only US official to visit the African continent recently: First Lady Jill Biden, the Secretary of State Anthony Blinken and Secretary of the Treasury Janet Yellen have all been in recent months. And they’re not alone either; Turkey and China’s Foreign Ministers made five-nation tours of Africa earlier this year. Russia’s Sergei Lavrov has also made several trips to the continent over the last few months. But why are countries courting African nations now? In today’s episode, we speak to our international editor, Lindsey Hilsum, about why the Ukraine war has intensified and accelerated a new scramble for Africa, and whether amidst all this jockeying for influence - the people on the continent once again get left behind?

Donald Trump has arguably done it all in his 76 years, and as president he’s secured a lot of firsts. But never has he been under arrest. The 45th president of the United States stands accused of falsifying business records in order to cover up payments he made to suppress news stories he believed would hinder his bid to become president in 2016. Trump pleaded not guilty and later left New York to fly back home to Mar-a-Lago in Florida, to deliver a defiant rally to his supporters. He was told by the judge to not do anything, yet he continues to rail against the system. In today’s episode we speak to presenter Matt Frei who has been in downtown Manhattan for the past few days, soaking up the history and scandal, and ask whether this is really the right first case to bring against the former president - and whether it may just embolden him even more. Producer: Freya Pickford Sources: AP

In Israel, a constitutional crisis has seen thousands take to the streets, fearing that their rights could be eroded, as the government plans to weaken the powers of the highest court in the land. Prime Minister Benjamin Netenyahu’s far-right coalition argues the Supreme Court is too powerful and they’re simply righting the wrongs of the system. Protesters say the overhaul would erode Israel’s proud democracy and lead them towards a dictatorship. After weeks of protests and pressure from all sides, Netanyahu finally backed down - but only slightly. He’s now paused the reforms ahead of the next session of parliament in a few weeks. In this episode, editor in chief of Haaretz Esther Solomon unpicks Israel’s biggest protests in decades - and wonders whether Netayanhu’s pause is a chance for his side to regroup of yet more battles to come.  

Rishi Sunak came into Downing Street back in October with a huge mess to clear up after the disaster of Liz Truss and her mini budget. After a week that has seen him secure his own Brexit Deal as, Boris Johnson struggled in front of a privileges committee over partygate, has he started to turn it around - can Rishi Sunak have what it takes to win the next election? In today's episode, Kiran Moodley speaks to our policy correspondent, Paul McNamara, about what Mr Sunak needs to do to win over the Red Wall - those Labour turned Tory voters from the last election - following an exclusive poll carried out by Channel 4 News and the polling company JL partners.  Sunak may have made Conservatives feel a bit more positive, but there’s still a long way to go before the next election, and is time on his side? Producer: Freya Pickford  

Three years ago this week, Boris Johnson announced a national lockdown to curb the spread of Coronavirus. But three years on, Covid and the impact of lockdowns continue to dominate our headlines.  This week, Boris Johnson faced a Commons inquiry on whether he misled parliament over the notorious lockdown parties, and just a few weeks ago, WhatsApp messages sent by Matt Hancock and others during the pandemic were leaked, with some claiming that they threw into question whether the government took the right path to control the pandemic. And there is still ongoing debate about whether this deadly virus began after a lab leak in China.  In today’s episode, Kiran Moodley speaks to Health and Social Care Editor Victoria Macdonald, as well Edinburgh University’s professor of Global Public Health Devi Sridhar, about whether the ongoing fallout and discussions around the pandemic have actually altered their views on what happened at the peak of the virus.  Sources: ITN, CNN  

Gary Linker and the BBC have been dominating the headlines after the Match of the Day host was asked to step back from presenting after tweeting out criticism of the government’s language around refugees. But what does this whole row mean for the BBC, and what does it say about the state of our media and its relationship to impartiality? In today’s podcast, we speak with Adam Boulton, formerly editor-at-large of Sky News, whether he thinks the BBC has an issue over impartiality.  

We were told to prepare for a “Winter of Discontent”, of strikes, rising prices, a coming recession with our economy set this year to shrink unlike all the rest. Even Russia was going to fare better than the UK. But it has not been as bad as once feared - so what is going on? In today’s episode, Business Reporter Neil Macdonald discusses the state of our economy ahead of next week’s budget and whether a slightly improved outlook means energy prices can remain low and strikes could even come to an end. Producer: Freya Pickford and Alice Wagstaffe 

China wants to be the superpower of the 21st century, but does it want to provoke war or play peacemaker? This week the country announced it was increasing military spending, and its newly installed foreign minister warned that if the US did not change course soon, there would be conflict. But China also recently published a 12-point plan for ending the conflict in Ukraine, despite not condemning Russia’s invasion. Ukrainian president Volodmyr Zelenskyy even said he would meet Chinese leader Xi Jinping to discuss the plans. So is this the moment where Beijing asserts itself on the world stage after being locked away during Zero Covid for so long?  In today’s episode, Kiran Moodley speaks to Rana Mitter, Professor of the History and Politics of Modern China at the University of Oxford, about China’s growing frustration with Moscow and the likelihood of a new Cold War. Producers: Freya Pickford and Alice Wagstaffe