Cardio Pod: Heart of the Matter
Introducing Heart of the Matter Cardio Pod. High-level conversations to foster conversation, collaboration, and communication around the ecosystem of cardiovascular research.
Latest episodes
Mar 13, 2025 • 39min
Standardized Definitions of Changes in Kidney Function in Trials of Heart Failure
Only with cardiology with nephrology working together can the field of acute decompensated heart failure move forward with respect to kidney related entry criteria & endpoints. We call for standardization to allow for real progress. Host Chris O'Connor invites authors of the HFC, newly published JACC Expert Panel, Anuradha Lala, Maria Rosa Costanzo, Muthu Vaduganathan, Jason Feinman, Mona Fiuzat, and Steven Coca to discuss this HF-ARC initiative.
Mar 30, 2024 • 31min
The Role of AI in the Future of Clinical Trials and Therapeutic Development
How can artificial intelligence enhance and augment clinical trials? In what ways can it be used responsibly to increase trial efficiency? Host Chris O'Connor invites Martin Cowie, JoAnn Lindenfeld, Scott Solomon, Jon Cunningham, Mona Fiuzat, and Mitch Psotka to discuss the role of AI in clinical trials.
7 snips
Jan 10, 2024 • 30min
Importance of Subgroups in Heart Failure Clinical Trials - Part 2
Experts in heart failure clinical trials, including Scott Solomon and JoAnn Lindenfeld, discuss the importance of analyzing subgroups in trials. They emphasize the challenges in interpreting data, the impact of therapy, and the need for personalized medicine for better treatment outcomes.
Nov 7, 2023 • 23min
Importance of Subgroups in Heart Failure Clinical Trials - Part 1
Cardiologists Javed Butler, Mariell Jessup, and Mitchell Psotka discuss the significance of subgroups in heart failure trials. They explore the impact of targeted participant categories, challenges of replicating trial results, and prioritizing subgroups for improved trial outcomes.
Aug 31, 2023 • 40min
DSMB Training Academy: Preparing the Next Generation (Part 2)
Dr. Christopher O'Connor interviews the founding members of the data safety monitoring board (DSMB) training team, Dr. David DeMets, Dr. Janet Wittes, and Dr. Thomas Flemming, to continue discussing the importance of training the next generation in clinical trial leadership. Using their extensive experience in clinical trials, they address which practices will best serve future members, and the critical shortage of trained experts.
Aug 10, 2023 • 31min
DSMB Training Academy: Preparing the Next Generation of Members (Part 1)
Drs. Janet Wittes, Mona Fiuzat, Maria Rosa Costanzo, Ana Barac, Barry Greenberg, Vanessa Blumer, and Michael Bristow come together on this episode with Dr. Christopher O'Connor to discuss initiatives to train the next generation of DSMB members. How do we pass on the experience and knowledge of seasoned DSMB members and properly train the next generation?
Jun 13, 2023 • 37min
Are we making progress with the recruitment of women in heart failure trials?
Drs. Mariell Jessup, JoAnn Lindenfeld, Maria Rosa Costanzo, Mona Fiuzat, Bill Abraham, and Wayne Batchelor join Christopher O'Connor to discuss the recruitment of women in HF clinical trials. What has been done so far and where do we go from here?
May 2, 2023 • 52min
Implications of the Advisory Committee Meetings for the Heart Failure Community
Drs. Peter Carson, JoAnn Lindenfeld, John Teerlink, Orly Vardeny, and Bill Abraham join Dr. Christopher O'Connor to discuss the implications of the FDA Advisory Committee meetings with special focus on three programs: TOPCAT (2:05), PARAGON-HF (15:53), and GALACTIC-HF (30:35).
Jan 26, 2023 • 26min
Diversity in Heart Failure Clinical Trials
Special guests Melvin Echols, Nasrien Ibrahim, Vanessa Blumer, Wayne Batchelor, JoAnn Lindenfeld, and Mitchell Psotka join the podcast to discuss the importance of enrolling diverse populations in HF clinical trials. How can we target a more representative population?
Jan 5, 2023 • 34min
The Intersection of Heart Failure and the Kidney
James Januzzi, Maria Rosa Costanzo, John Teerlink, Marv Konstam, Bill Abraham, and nephrologist Steven Coca join the podcast to discuss HF and AKI. How should we react to rising creatinine?
