Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf

In this episode of the Peptides & Longevity Podcast, Dr. George Rice joins us to explore the vital role of mitochondrial health in energy, longevity, and chronic disease. We also dive into how mitochondrial peptides can help reverse aging-related dysfunctions and ignite optimal health from the cellular level up.In this episode of the Peptides & Longevity Podcast, Dr. George Rice joins us to explain why the key to reversing chronic disease and aging might be hidden inside our mitochondria. These tiny energy factories do far more than just fuel our cells—they regulate calcium, cell survival, inflammation, insulin sensitivity, and more. As we age, mitochondrial function declines, leading to everything from fatigue to neurodegeneration. Dr. Rice emphasizes that rather than viewing this dysfunction as inevitable, we now have powerful tools to support and restore mitochondrial health, particularly through mitochondrial-derived peptides like MOTS-c.Dr. Rice also discusses the science and clinical experience behind using MOTS-c and other mitochondrial-targeted peptides to treat patients with conditions like heart failure, autoimmune issues, chronic fatigue, and metabolic disorders. He also unpacks the importance of personalized medicine, epigenetic testing, and functional diagnostics to tailor interventions to the individual. Whether it’s hormone balancing, strategic peptide use, or nutrition that fuels mitochondrial resilience, this episode gives you an inspiring, data-backed approach to not just living longer, but living better.Dr. George Rice is a board-certified physician specializing in functional and precision performance medicine, with a mission to help patients not just survive but thrive.. Dr. Rice holds multiple certifications, including from the Institute for Functional Medicine, the Academy of Preventative and Innovative Medicine, and the Age Management Medical Group. Known for his dynamic, patient-centered approach, he combines advanced diagnostic testing with cutting-edge therapies like peptide treatments, hormone optimization, and epigenetic coaching to help clients reach peak physical performance, youthful vitality, and lasting longevity. His work is guided by the belief that optimal health is achievable at any age—and that the mitochondria are the key to unlocking it.Dr. George RiceWebsite: https://ileraprecisionwellness.com/dr-george-rice--------Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

In this episode of the Peptides & Longevity Podcast, Dr. Amy Derksen joins me to share how peptide therapies and immune-modulating treatments are transforming care for patients with immune-driven conditions like autism, Lyme disease, and PANS/PANDAS. She also reveals her integrative, science-backed approach to treating the most sensitive and complex patients who often fall through the cracks of conventional medicine. Dr. Amy Derksen pulls back the curtain on what it takes to treat the most often-overlooked patients—those with chronic infections, autism spectrum disorders, and PANS/PANDAS. With years of clinical expertise and training, she shares how immune modulation, not just antimicrobial treatment, is the key to getting patients better. She explains how therapies like peptides can restore immune balance and reduce hypersensitivity in even the most treatment-resistant cases. We also dive into the misunderstood world of cellular senescence—damaged, energy-draining cells that can persist long after an infection clears. If you or someone you love has been told ‘there’s nothing you can do,’ this episode may be the turning point.Dr. Amy Derksen is a naturopathic physician and the founder of Holistic Healing Arts, with over two decades of experience treating complex chronic illnesses. A graduate of Bastyr University, she trained under Dr. Dietrich Klinghardt and became a leading instructor in his autonomic response testing method. Dr. Derksen specializes in autism, PANS/PANDAS, Lyme disease, and mold-related illness, bringing a personalized, biochemistry-informed approach to care.With a background in biochemistry and a deep understanding of detoxification, methylation, and mitochondrial health, she integrates cutting-edge research with holistic protocols. Dr. Derksen also draws from personal experience with mold illness and post-viral immune dysregulation, giving her unique insight into the healing journey. Outside of her practice, she stays active in nature through mountain biking, hiking, trail running, skiing, and paddleboarding.Dr.Amy DerksenInstagram: https://www.instagram.com/dramyderksen/Website: https://www.holistichealingarts.org/----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

Dr. Matt Cook joins me in this episode of the Peptides & Longevity Podcast to share how he helps patients overcome chronic pain using advanced regenerative tools like peptides, nerve hydrodissection, vagus nerve stimulation, and functional neurology. We also dive into why pain is often a ‘software problem’ and how reprogramming the nervous system can lead to lasting healing.Chronic pain is more than a symptom—it’s a message from the brain. In this episode, Dr. Matt Cook reveals his unique approach to pain management using peptides, hydrodissection, and nervous system retraining. Learn why reprogramming brain-body signals is the key to reversing pain and restoring function.Dr. Matt Cook is a regenerative medicine specialist and founder of BioReset Medical. With a background in anesthesiology and functional medicine, he combines the best of conventional and alternative approaches to treat complex chronic pain, inflammation, and neurological conditions. Known for his precision use of peptides, injection therapies, and neuroregulation, Dr. Cook works with elite athletes, chronically ill patients, and health pioneers seeking true healing from the inside out.----Dr.Matt CookInstagram: https://www.instagram.com/bioresetmedical/ LinkedIn: https://www.linkedin.com/company/bioreset-medical/Facebook: https://www.facebook.com/BioResetMedicalWebsite: https://www.bioresetmedical.com/----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

In this episode, Dr. Heather Sandison joins me to share her integrative, root-cause approach to reversing cognitive decline using detoxification, nutrient repletion, structural support, and timed peptide therapy. She explains how addressing toxicity, infections, and stress management—along with targeted neurohacking tools—can unlock the brain’s healing potential, even in advanced neurodegenerative case.Dr. Heather Sandison is the founder of Solcere Health Clinic and Marama, the first residential care facility for the elderly of its kind. At Solcere, she and her team of doctors and health coaches focus primarily on supporting patients looking to optimize cognitive function, prevent mental decline, and reverse dementia by addressing root causes of imbalance in the brain and body.She was awarded a grant to study an individualized, integrative approach to reversing dementia and is a primary investigator on the ITHNCLR clinical trial.At Marama, Dr. Sandison has created an immersive residential experience in the lifestyle proven to best support brain health. She understands that changing your diet, adding nutrients, creating community, and optimizing a healing environment are all challenging even for those with full cognitive capacity. At Marama, she’s done the work for you. All you need to do is show up.Instagram: https://www.instagram.com/dr.heathersandison/ LinkedIn: https://www.linkedin.com/in/heather-sandison-nd-31357241/Website: https://www.drheathersandison.com/----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

In this episode, I’m joined by Reagan Archibald, a functional medicine practitioner and entrepreneur, to explore the future of healthcare. We discuss the shift from fragmented, fee-for-service care to a more collaborative, integrative model. This approach leads to better patient outcomes and helps reduce burnout for healthcare practitioners. We dive into the role of peptide therapy as a game-changer in functional medicine, explaining how peptides are a key part of a holistic approach to optimal health. If you’re looking for insights into healthcare innovation, personal growth, and better health outcomes, this episode is for you.Reagan Archibald, LAc, Dipl OM, is a functional medicine practitioner and entrepreneur dedicated to combining holistic therapies like acupuncture and peptides to optimize health. He’s a passionate advocate for patient-centered care, working to integrate multiple medical disciplines for sustainable health solutions.----Reagan Archibald, LAc, Dipl OMLinkedin: https://www.linkedin.com/in/regan-archibald-ab70b813/Website: https://thepeptideexpert.com/----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

Everyday EMF exposure from gadgets might be doing more harm than you think. These invisible culprits can lead to neurological problems, immune issues, and even speed up aging. Discover how peptides can help combat these adverse effects and restore your health. Learn why children are particularly vulnerable to EMF toxicity and how integrating peptide solutions could enhance immune function. If you've been grappling with chronic fatigue or brain fog, this discussion might just unveil the key to feeling rejuvenated!

Did you know that hidden inflammation could be silently aging you and increasing your risk of chronic disease? Dr. James LaValle calls this “metaformation”—metabolic inflammation that disrupts everything from iron metabolism to brain health. In this episode, he reveals how stress, poor diet, and environmental toxins fuel inflammation, accelerating aging. Discover how integrative medicine, peptides, and personalized nutrition can help restore balance and resilience.Feeling constantly drained, struggling with brain fog, or noticing weight that won’t budge despite your best efforts? It’s not just aging. These could be signs of metaformation—a hidden inflammatory process silently sabotaging your metabolism, energy, and overall health. In this episode, I sit down with Dr. James LaValle to uncover the biggest metabolic disruptors and, more importantly, the science-backed strategies to take control, reverse the damage, and optimize longevity. If you’ve been frustrated with conventional advice that doesn’t work, you won’t want to miss this conversation.Dr. James LaValle is a clinical pharmacist, board-certified clinical nutritionist, and metabolic expert specializing in personalized health strategies. With decades of experience in integrative and functional medicine, he is the author of Cracking the Metabolic Code and a thought leader in using peptides, hormone balancing, and nutrient therapy to optimize longevity and wellness.-----Dr. James LaValleLinkedin: https://www.linkedin.com/in/james-lavalle-1a6b8858/Facebook: https://www.facebook.com/people/James-LaValle/100009162878946/?_rdrInstagram: https://www.instagram.com/therealjimlavalle/?hl=en----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

In this episode, Kashif Khan, founder of The DNA Company, dives into the transformative power of personalized DNA testing and its role in revolutionizing health. After facing his own health challenges, Kashif used genetic insights to create a company that blends genomics with lifestyle factors to offer tailored health solutions. Discover how understanding your DNA can optimize detoxification and hormone health and even manage chronic conditions like cardiovascular disease and mood disorders.What if your DNA held the secret to achieving your optimal health? In this episode, Kashif Khan, founder of The DNA Company, shares how personalized DNA testing is changing the way we manage our health. From detoxification and hormone balance to preventing chronic diseases and improving mental health, learn how integrating genetic data with lifestyle factors can unlock a new level of personalized wellness.Kashif Khan is the founder and executive officer of The DNA Company. With a background in business and marketing, Kashif transitioned to personalized medicine after using his own genetic testing to uncover health issues like migraines and eczema. He is now pioneering the field of DNA-based health optimization, offering insights into how genes, lifestyle, and environment work together to shape our well-being.----Kashif KhanLinkedin: https://www.linkedin.com/in/mrkashkhan/Facebook: https://www.facebook.com/p/Kashif-Khan-100077741625937/ Instagram: https://www.instagram.com/kashkhanofficial/?hl=en----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

In this episode, I chat with Jim Prather, President of WAVi Medical, about their revolutionary brain function measurement technology that helps assess health and performance. Jim shares his journey from tech and consumer electronics to discovering the need for reliable tools to measure brain function. WAVi is changing the way we track brain health, offering athletes, clinicians, and patients with neurological conditions objective data on performance, recovery, and overall brain health. Whether you’re recovering from an injury or just interested in monitoring your brain functions, this conversation is packed with insights!Have you ever wondered how you can objectively track your brain health? In this episode, Jim Prather reveals how WAVi is helping to revolutionize brain health monitoring. From concussion recovery for athletes to detecting neurological dysfunction in chronic illnesses, WAVi’s technology is making waves in brain performance. Tune in to discover how this groundbreaking device could change how we view brain health.Jim Prather is the President and CFO of WAVi Medical. With a background in information technology and consumer electronics, Jim is driving WAVi’s mission to revolutionize brain health by providing accurate and objective data for monitoring brain function.----Jim PratherLinkedin: https://www.linkedin.com/in/jimprather/----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

Join me as I chat with Dr. Joseph Raffaele, a leading expert in age management and telomere biology. In this episode, we dive deep into the fascinating world of telomeres and their role in the aging process. Dr. Raffaele explains how his groundbreaking work with PhysioAge Systems is changing the game in age management, offering insights into how telomere length, epigenetics, and cellular changes can be monitored to extend longevity and vitality. We also explore how these scientific discoveries are influencing personalized health strategies for aging gracefully.Dr. Joseph Raffaele is a leader in age management medicine and a co-founder of PhysioAge Medical Group. He is a renowned expert in clinical telomere biology and has contributed extensively to research on aging. Dr. Raffaele earned his BA from Princeton and his MD from Drexel University Medical Center, and completed his training at NYU and Cornell. He is board-certified in internal medicine and anti-aging medicine.----Dr.Joseph RaffaeleLinkedin: https://www.linkedin.com/in/joseph-raffaele-md-56105a28/Instagram: https://www.instagram.com/raffaelemd/?hl=en----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/