Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf

Discover how your gut’s microbial balance affects everything from stress to drug absorption. In this episode of Peptides & Longevity, Afif Ghannoum joins us to unpack the science of the gut microbiome and reveals how imbalances in this ecosystem can disrupt digestion, drug effectiveness, stress response, and immunity.In this episode of Peptides & Longevity, Afif Ghannoum, a biotechnology entrepreneur, breaks down the emerging science of the total microbiome—including bacteria, fungi, and viruses—and its massive impact on digestion, disease, drug response, and overall health. He shares insights from his father, Dr. Mahmoud Ghannoum, who coined the term ‘mycobiome’ and has led groundbreaking research into how fungi and bacteria form biofilms in the gut, driving inflammation and digestive disorders. Together, they developed BIOHM Health to bring this research to consumers with innovative testing and probiotic solutions.Afif also reveals surprising truths—like how stress, over-exercise, and restrictive diets can damage the microbiome, and how fungi aren’t inherently bad but vital to gut balance. He explains why prebiotics (dietary fibers that nourish good microbes) may be more important than probiotics alone, and how proper microbial balance affects pain, stress response, immunity, and even medication effectiveness. This is a powerful conversation for anyone who’s struggled with gut issues, chronic symptoms, or confusion about which ‘health rules’ to follow.Afif GhannoumWebsite: https://www.biohmhealth.com/LinkedIn: https://www.linkedin.com/in/afifghannoum/Instagram: https://www.instagram.com/biohmhealth/ ----------Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

Could balancing this overlooked system be the key to recovering from COVID-19? In this episode of Peptides & Longevity, Dr. Leo Galland joins us to unpack the critical role of the angiotensin pathway and peptides in addressing inflammatory bowel disease and even complications from COVID-19. He also shares insights into balancing the body’s natural systems to prevent infection, heal inflammation, and restore health.In this episode of Peptides & Longevity, Dr. Leo Galland dives deep into the science behind the angiotensin pathway and how its imbalance plays a major role in the severity of infections from COVID-19. He explains how the angiotensin pathway protects the heart, brain, and blood vessels, and how the virus hijacks this system to wreak havoc. He explores how blocking furin with peptides could prevent the virus from replicating at its first point of entry, the nose.Dr. Galland also highlights his pioneering work with certain peptides for treating inflammatory bowel disease and other gut conditions. He shares practical, individualized strategies that go far beyond one-size-fits-all medicine, emphasizing the importance of the gut microbiome, the viral biome, and how these emerging tools can help patients heal when mainstream treatments fail. This is a must-watch for anyone curious about the future of peptides, immune health, and personalized healing.Dr. Leo Galland is a board-certified internist and recognized leader in integrative and functional medicine, specializing in the evaluation and treatment of patients of all ages with complex chronic disorders. A graduate of Harvard University and the New York University School of Medicine, he has pioneered the study of the gut microbiome and intestinal permeability decades before they became mainstream, transforming how we understand the links between digestive health, inflammation, and immune resilience.Known for developing innovative nutritional therapies for autoimmune, inflammatory, allergic, infectious, and gastrointestinal conditions, Dr. Galland views the doctor-patient relationship as a true partnership, empowering people to take control of their own healing journey. His groundbreaking work has earned him multiple awards, including the Linus Pauling Award from the Institute for Functional Medicine and the Albert Nelson Marquis Lifetime Achievement Award. He serves on the medical advisory board of The Global Lyme Alliance and the Long Covid Advisory Group of the World Health Network, continuing to push the boundaries of what’s possible in personalized medicine.Website: https://www.drgalland.com/Facebook: https://www.facebook.com/leogallandmd/ Instagram: https://www.instagram.com/dr.leogalland/-----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

Toxins, trauma, and the protocol that changed everything. Can it work for you, too? In this episode of Peptides & Longevity, Scott Forsgren joins us to share his powerful journey recovering from chronic Lyme disease and mold illness after decades of misdiagnoses and struggle. He breaks down his protocol for healing complex chronic conditions, focusing on root causes like toxins, environment, and emotional trauma.In this episode of Peptides & Longevity, Scott Forsgren, a functional diagnostic nutrition practitioner, joins us to open up about his journey recovering from chronic Lyme disease and mold illness. After a tick bite left him battling intense symptoms and misdiagnoses, he shares how he refused to settle for ‘it’s all in your head,’ instead uncovering deeper root causes like hidden infections, mold exposure, and environmental toxins.Scott also details his proven protocol that starts with detoxification and drainage, optimizing your external environment, and calming the limbic system. From emotional trauma work to sleep and immune modulation, he explains why true recovery goes far beyond antibiotics—and how new tools like energetic testing and peptides can help restore the body’s natural balance. Packed with practical tips and hope, this is a must-watch for anyone dealing with Lyme, mold illness, or other complex chronic conditions.Scott Forsgren, FDN-P, NC, is a globally recognized health coach, researcher, and educator specializing in complex chronic illnesses like Lyme disease and mold illness. As the founder of BetterHealthGuy.com and host of the BetterHealthGuy Blogcast, he has spent over two decades interviewing the world’s leading integrative and functional medicine experts, translating his own recovery journey into practical, hope-filled guidance for others.Scott is a passionate advocate for empowering patients to look beyond symptom suppression and address the terrain that allows illness to thrive. He serves on the Board of Directors for the LymeLight Foundation, has written for numerous publications, and organizes the annual Forum for Integrative Medicine, bringing together top practitioners to share cutting-edge solutions. Whether it’s detoxification, drainage, peptides, or mind-body healing, his mission is clear: to help people reclaim their health—and their hope.-----Scott Forsgren, FDN-P, NCWebsite: https://www.betterhealthguy.com/LinkedIn: https://www.linkedin.com/in/sforsgren/Facebook: https://www.facebook.com/BetterHealthGuy Instagram: https://www.instagram.com/betterhealthguy/ -----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

What if peptides could transform cancer treatment? In this episode of Peptides & Longevity, Dr. Leigh Erin Connealy joins us to share her pioneering approach to integrative cancer care—blending conventional treatments with cutting-edge peptide therapies and personalized protocols. She also discusses how early detection, immune optimization, and patient-specific regimens are transforming outcomes for cancer patients.In this episode of Peptides & Longevity, Dr. Leigh Erin Connealy, a leading voice in integrative oncology, joins us to bring an inspiring and personal perspective to cancer treatment. Dr. Connealy details her evolution from conventional medicine to pioneering a multifaceted, whole-body approach to healing. Fueled by her own health challenges and a passion for prevention, she outlines how she integrates traditional cancer care with advanced diagnostics, immune optimization, and peptide therapies to improve patient outcomes radically.Dr. Connealy highlights the power of peptides like Thymosin Alpha 1 and PNC-27, as well as how tests such as RGCC and cancer profiles allow her to tailor treatments with precision. From tackling fatty liver and high blood sugar in cancer patients to using laser and intravenous therapies for non-toxic, targeted support, her clinic is a hub for innovation. Her mission is clear: shift the paradigm from reactionary to proactive medicine, and give patients real hope and control over their healing.Dr. Leigh Erin Connealy is a globally recognized leader in integrative and functional medicine, specializing in comprehensive cancer care and chronic illness prevention. As the Medical Director of the Center for New Medicine and the Cancer Center for Healing in Irvine, California, Dr. Connealy has spent over three decades developing a revolutionary approach to cancer treatment—one that blends the best of conventional medicine with advanced integrative therapies, personalized diagnostics, and cutting-edge peptide protocols.Known for her commitment to early detection, immune system optimization, and root-cause healing, Dr. Connealy and her team offer multi-disciplinary, patient-centered care that addresses the full complexity of disease. She is the author of ‘The Cancer Revolution and Be Perfectly Healthy,’ and a frequent educator, speaker, and mentor to practitioners worldwide. Her mission is bold but clear: to transform the cancer care model from reactive to proactive—and to help every patient not just fight cancer, but thrive.Dr. Leigh Erin ConnealyWebsite: https://cancercenterforhealing.com/LinkedIn: https://www.linkedin.com/in/leigherinconnealy/  -----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

Nafysa Parpia, an integrative medicine doctor known for her work with chronic illnesses like Lyme disease and mold toxicity, shares her revolutionary treatment methods. She discusses how a layered approach using detoxification, peptide therapy, and immune modulation accelerates recovery. Parpia highlights breakthrough peptides such as BPC-157 and TB4 that cut recovery times and restore vitality. With real patient testimonials, she reveals how her holistic strategies are reshaping the healing landscape, offering hope to those who’ve struggled for years.

In this episode, I sit down with Dr. Farshid Rahbar to explore why so many digestive issues come with non-GI symptoms like fatigue, skin rashes, and brain fog. We dig into fungal overgrowth, stealth infections, and how peptides like BPC-157 and TB4-Frag may help restore gut integrity and systemic health.In this episode, I talk with Dr. Farshid Rahbar about how digestive disorders often present with non-digestive symptoms like fatigue, skin issues, and brain fog. He shares how fungal overgrowth, stealth infections, and environmental toxins can fuel chronic GI problems, and why conventional tests often miss the mark. We explore peptide therapy, comprehensive testing, and his holistic strategy for treating complex patients.----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

Could peptides be the key to restarting stalled healing? In this episode of Peptides & Longevity, Dr. Eric Gordon shares a paradigm-shifting perspective on chronic illness through the lens of metabolomics, mitochondrial function, and the cell danger response. He reveals how chronic conditions are less about broken systems and more about misfiring healing cycles—and where peptides may help guide recovery.In this episode of Peptides & Longevity, Dr. Eric Gordon unpacks decades of insight into the root mechanisms behind chronic illness. He introduces listeners to metabolomics—a scientific field that tracks thousands of small molecules in the body to reveal hidden dysfunctions in metabolism, inflammation, and mitochondrial signaling. Dr. Gordon explains how chronic fatigue syndrome and other illnesses may stem from a prolonged ‘cell danger response,’ where the body gets trapped in a state of protective shutdown, despite the original threat having passed.Dr. Gordon discusses the implications of this model on diagnosis and treatment. Standard labs often fail to capture these dynamics, leading to misdiagnosis or dismissal of real suffering. Instead, he advocates for understanding the cell’s healing phases, especially the role mitochondria play not just in energy production, but in immune communication. He also touches on the powerful potential of peptides like BPC-157 and thymosins, which can nudge the body out of chronic inflammation and support more complete healing. This conversation reframes chronic illness from a frustrating mystery into a process we can finally begin to understand—and influence.Dr. Eric Gordon is a pioneering integrative physician with over four decades of clinical experience specializing in complex chronic illness. As the founder of Gordon Medical Associates and president of the Gordon Medical Research Center in the San Francisco Bay Area, he has dedicated his career to helping patients who often fall through the cracks of conventional medicine—those with chronic fatigue syndrome, Lyme disease, fibromyalgia, mast cell activation, and autoimmune conditions.A passionate collaborator and educator, Dr. Gordon co-authored the groundbreaking study ‘Metabolic Features of Chronic Fatigue Syndrome’ published in the Proceedings of the National Academy of Sciences. This work introduced the revolutionary concept of the cell danger response, a framework that redefines chronic illness as a stuck healing process rather than ongoing damage. Today, Dr. Gordon continues to explore how metabolomics, mitochondrial health, and peptides intersect to reshape diagnosis and treatment in chronic disease. His work bridges research and real-world care, empowering both practitioners and patients to think differently and act more effectively.----Dr. Eric GordonWebsite: https://www.gordonmedical.com/  Instagram: https://www.instagram.com/gordonmedical/ LinkedIn: https://www.linkedin.com/in/eric-gordon-2329ba30/ Facebook: https://www.facebook.com/gordonmedical ----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

Is chronic inflammation sabotaging your energy? In this episode of Peptides & Longevity, Dr. Suresh Raja joins us to reveal how chronic inflammation disrupts mitochondrial function and how his proprietary oral peptide can help restore cellular energy, enhance bioenergetics, and support self-healing. From advanced heart rate variability diagnostics to home-based wearables, he outlines a full-spectrum approach to measuring and rescuing mitochondrial health affordably and effectively.In this episode of Peptides & Longevity, Dr. Suresh Raja shares his pioneering approach to restoring mitochondrial health through a unique combination of oral peptide therapy, real-time energetic diagnostics, and personalized metabolic monitoring. At the heart of his method is Karnozin Extra—a proprietary, two-amino-acid peptide with unparalleled bioavailability that resists enzymatic breakdown and acts as a potent antioxidant, anti-inflammatory, and mitochondrial protector. Dr. Raja explains how this supplement has shown remarkable results in both animal studies and human trials, improving energy, mood, pain, and even neural protection in multiple sclerosis patients.The conversation dives deeper into measuring mitochondrial fuel, oxygen, and voltage through advanced wearables and heart rate variability monitoring tools, making biofeedback accessible from home. Dr. Raja also unpacks the synergy between his peptide stack and modalities like hyperbaric oxygen therapy, photobiomodulation, and electroceuticals. His ‘mitochondrial rescue’ approach doesn’t just help sick patients—it's also being used by elite athletes and those focused on anti-aging.Dr. Suresh Raja is a board-certified otolaryngologist and medical innovator with over 25 years of experience in minimally invasive procedures and advanced metabolic therapies. After witnessing a surge in chronic illness, neurodegeneration, and fatigue in increasingly younger patients, Dr. Raja pivoted his career toward mitochondrial medicine, focusing on cellular energy, bioenergetics, and self-healing through novel peptide and wearable technologies.He is the creator of Karnozin Extra, a proprietary oral neuropeptide with exceptional bioavailability that resists enzymatic breakdown and targets mitochondrial dysfunction at the root. As the Chief Metabolism Officer at Mitochondria Rescue and Evolution Hyperbaric Institute, Dr. Raja has integrated real-time biofeedback, heart rate variability testing, and energy diagnostics into personalized care protocols designed to reduce inflammation, restore energy production, and optimize mitochondrial voltage. His mission is simple but profound: make measurable healing accessible, affordable, and transformative—both for patients and the practitioners who care for them.----Dr. Suresh RajaWebsite: https://sureshrajamd.com/----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

Could collagen and mushrooms hold the key to managing inflammation and autoimmune issues? In this episode of Peptides & Longevity, Dr. Melissa Gallagher explores the healing potential of food-based peptides from collagen and medicinal mushrooms and their profound impact on gut health, immune balance, and lymphatic function. She also reveals how natural peptide therapies can be used to manage chronic inflammation, autoimmune conditions, and lymphedema by tapping into the body’s innate detox and regenerative systems.In this episode of Peptides & Longevity, Dr. Melissa Gallagher joins us to share how she combines peptide-based nutrition with functional medicine to help patients overcome chronic illness, inflammation, and immune dysfunction. She explains how multi-sourced collagen peptides—especially when derived from clean bovine, marine, and eggshell sources—can rejuvenate skin, heal wounds, and boost cellular recovery. We also dive into the world of functional mushrooms, highlighting how bioavailable fermentation methods and powerful compounds like polysaccharide peptides work at the genetic level to support immunity and epigenetic health.The conversation also takes a deeper turn into the often-overlooked lymphatic system. Drawing on her clinical experience, Dr. Gallagher shares therapeutic approaches to support lymphatic flow and reduce inflammation, including enzyme therapy, dry brushing, and nutritional protocols. She emphasizes that many chronic illnesses, from autoimmunity to cancer recovery, involve congested lymphatics and digestive dysfunction—and that natural peptide therapy offers a gentle, effective way to reawaken the body’s detox and healing systems. For anyone dealing with complex or lingering health issues, this episode is a powerful invitation to explore a food-first, peptide-powered approach to wellness.Dr. Melissa Gallagher is a board-certified naturopathic physician and certified lymphatic therapist with over a decade of experience in holistic healing, nutritional therapy, and immune support. After overcoming a personal health crisis, she committed to helping others harness the body’s natural healing potential through food-based medicine, peptide therapies, and lymphatic health. Dr. Gallagher specializes in complex cases involving digestive dysfunction, autoimmune disease, chronic inflammation, and lymphedema, using a ‘food first’ approach that emphasizes bioavailable peptides from collagen, mushrooms, and therapeutic enzymes. Her clinical philosophy combines natural therapies with advanced diagnostic insights, empowering patients to take control of their healing and thrive long term.----Dr.Melissa GallagherWebsite: https://organixx.com/YouTube: https://www.youtube.com/c/NaturalHealthResources Instagram: https://www.instagram.com/naturalhealthresources----Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/

In this episode of the Peptides & Longevity Podcast, Dr. George Rice joins us to explore the vital role of mitochondrial health in energy, longevity, and chronic disease. We also dive into how mitochondrial peptides can help reverse aging-related dysfunctions and ignite optimal health from the cellular level up.In this episode of the Peptides & Longevity Podcast, Dr. George Rice joins us to explain why the key to reversing chronic disease and aging might be hidden inside our mitochondria. These tiny energy factories do far more than just fuel our cells—they regulate calcium, cell survival, inflammation, insulin sensitivity, and more. As we age, mitochondrial function declines, leading to everything from fatigue to neurodegeneration. Dr. Rice emphasizes that rather than viewing this dysfunction as inevitable, we now have powerful tools to support and restore mitochondrial health, particularly through mitochondrial-derived peptides like MOTS-c.Dr. Rice also discusses the science and clinical experience behind using MOTS-c and other mitochondrial-targeted peptides to treat patients with conditions like heart failure, autoimmune issues, chronic fatigue, and metabolic disorders. He also unpacks the importance of personalized medicine, epigenetic testing, and functional diagnostics to tailor interventions to the individual. Whether it’s hormone balancing, strategic peptide use, or nutrition that fuels mitochondrial resilience, this episode gives you an inspiring, data-backed approach to not just living longer, but living better.Dr. George Rice is a board-certified physician specializing in functional and precision performance medicine, with a mission to help patients not just survive but thrive.. Dr. Rice holds multiple certifications, including from the Institute for Functional Medicine, the Academy of Preventative and Innovative Medicine, and the Age Management Medical Group. Known for his dynamic, patient-centered approach, he combines advanced diagnostic testing with cutting-edge therapies like peptide treatments, hormone optimization, and epigenetic coaching to help clients reach peak physical performance, youthful vitality, and lasting longevity. His work is guided by the belief that optimal health is achievable at any age—and that the mitochondria are the key to unlocking it.Dr. George RiceWebsite: https://ileraprecisionwellness.com/dr-george-rice--------Integrative PeptidesWebsite: https://integrativepeptides.com/Facebook: https://www.facebook.com/integrativepeptidesofficial/Instagram: https://www.instagram.com/integrativepeptides/----Holtorf Medical GroupWebsite: https://holtorfmed.com/Facebook: https://www.facebook.com/holtorfmed/Instagram: https://www.instagram.com/holtorfmedicalgroup/----Kent Holtorf, MDYouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A----Produced by DrTalks  https://drtalks.com/podcast-service/