Flex Diet Podcast

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References:Adriana Sarah Nica, Adela Caramoci, Mirela Vasilescu, Anca Mirela Ionescu, Denis Paduraru, Virgil Mazilu.  Magnesium supplementation in top athletes - effects and recommendations. Medicina Sportiva (2015), vol. XI, no 1, 2482-2494 Journal of the Romanian Sports Medicine SocietyAikawa JW. Magnesium: its biological significance. Boca Raton, FL: CRC Press, 1981:21–38.Abbasi B, Kimiagar M, Sadeghnijat K, Shirazi MM, Hedayati M, Rashidkhani B. “The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.”  J Res Med Sci. 2012 Dec 17 (12): 1161-9.PubMed PMID: 23853635. Arnaud MJ: Update on the assessment of magnesium status. Br J Nutr 2008;99(suppl 3):S24–S36 Brilla LR, Haley TF. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr 1992;11:326​​​​​​​Chandrasekaran NC, Weir C, Alfraji S, Grice J, Roberts MS, Barnard RT. Effects of magnesium deficiency--more than skin deep. Exp Biol Med (Maywood). 2014 Oct;239(10):1280-91. doi: 10.1177/1535370214537745. Epub 2014 Jun 13.Ebel H, Gunther T. Magnesium metabolism: a review. J Clin Chem Biochem 1980;18:257–70.Emelyanov A, Fedoseev G, Barnes PJ: Re- duced intracellular magnesium concentra- tions in asthmatic patients. Eur Respir J 1999;13:38–40.Fawcett WJ, Haxby EJ, Male DA: Magnesium: physiology and pharmacology. Br J Anaesth 1999;83:302–320.Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press, 1997.Guerrero-Romero F, Rodríguez-Morán M. Relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects. Int J Obes Relat Metab Disord. 2002;26:469–74.Hosty´nek JJ, Hinz RS, Lorence CR, Price M, Guy RH. Metals and the skin. Crit Rev Toxicol 1993;23:171–235Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J 2012;5:i3–i14Kupetsky-Rincon EA1, Uitto J. Magnesium: novel applications in cardiovascular disease--a review of the literature. Ann Nutr Metb. 2012;61(2):102-10.Lansdown AB. Physiological and toxicological changes in the skin resulting from the action and interaction of metal ions. Crit Rev Toxicol1995;25:397–462.Mochizuki M, Akagi K, Inoue K, Shimamura K.[A single dose toxicity study of magnesium sulfate in rats and dogs]. J Toxicol Sci. 1998 May;23 Suppl 1:31-5Navarrete-Cortes A, Ble-Castillo JL, Guerrero-Romero F, Cordova-Uscanga R, Juárez-Rojop IE, Aguilar-Mariscal H, Tovilla-Zarate CA, Lopez-Guevara Mdel R. No effect of magnesium supplementation on metabolic control and insulin sensitivity in type 2 diabetic patients with normomagnesemia. 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ReferencesBartoszewska M, Kamboj M, Patel DR (2010) Vitamin D, muscle function, and exercise performance. Pediatr Clin North Am 57:849-861. doi:10.1016/j.pcl.2010.03.008 Brazier M, Grados F, Kamel S et al (2005) Clinical and laboratory safety of one year's use of a combination calcium + vitamin D tablet in ambulatory elderly women with vitamin D insufficiency: results of a multicenter, randomized, double-blind, placebo-controlled study. Clin Ther 27:1885-1893. doi:10.1016/j.clinthera.2005.12.010 Hoang MT, Defina LF, Willis BL, Leonard DS, Weiner MF, Brown ES. (2011) Association between low serum 25-hydroxyvitamin D and depression in a large sample of healthy adults: the Cooper Center longitudinal study. Mayo Clin Proc. 2011 Nov;86(11):1050-5.Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL (2011) Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 26:2341-2357. doi:10.1002/jbmr.463; 10.1002/jbmr.463 Jones G (2008) Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 88:582S-586S Karaplis AC, Chouha F, Djandji M, Sampalis JS, Hanley DA (2011) Vitamin D status and response to daily 400 IU vitamin D3 and weekly alendronate 70 mg in men and women with osteoporosis. Ann Pharmacother 45:561-568. doi:10.1345/aph.1P439 Kimball SM, Ursell MR, O'Connor P, Vieth R (2007) Safety of vitamin D3 in adults with multiple sclerosis. Am J Clin Nutr 86:645-651 Koutkia P, Chen TC, Holick MF (2001) Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 345:66-67. doi:10.1056/NEJM200107053450114 Lips P, Binkley N, Pfeifer M et al (2010) Once-weekly dose of 8400 IU vitamin D(3) compared with placebo: effects on neuromuscular function and tolerability in older adults with vitamin D insufficiency. Am J Clin Nutr 91:985-991. doi:10.3945/ajcn.2009.28113 Maalouf J, Nabulsi M, Vieth R et al (2008) Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children. J Clin Endocrinol Metab 93:2693-2701. doi:10.1210/jc.2007-2530 Matthews LR, Ahmed Y, Wilson KL, Griggs DD, Danner OK (2012) Worsening severity of vitamin D deficiency is associated with increased length of stay, surgical intensive care unit cost, and mortality rate in surgical intensive care unit patients. Am J Surg . doi:10.1016/j.amjsurg.2011.07.021 Roth DE (2011) Vitamin D supplementation during pregnancy: safety considerations in the design and interpretation of clinical trials. J Perinatol 31:449-459. doi:10.1038/jp.2010.203; 10.1038/jp.2010.203 Vieth R (1999) Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 69:842-856 Vieth R (1999) Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 69:842-856 Wang Y, DeLuca HF (2011) Is the vitamin d receptor found in muscle? Endocrinology 152:354-363. doi:10.1210/en.2010-1109 Wielders JP, Muskiet FA, van de Wiel A (2010) Shedding new light on vitamin D--reassessment of an essential prohormone. Ned Tijdschr Geneeskd 154:A1810 

References :Rucklidge JJ, Kaplan BJ. Broad-spectrum micronutrient formulas for the treatment of psychiatric symptoms: a systematic review. Expert review of neurotherapeutics. 2013;13(1):49-73.Rucklidge J, Johnstone J, Harrison R, Boggis A. Micronutrients reduce stress and anxiety in adults with Attention-Deficit/Hyperactivity Disorder following a 7.1 earthquake. Psychiatry research. 2011;189(2):281-7.Rucklidge JJ, Johnstone J, Kaplan BJ. Nutrient supplementation approaches in the treatment of ADHD. Expert review of neurotherapeutics. 2009;9(4):461-76.Gardner A, Kaplan BJ, Rucklidge JJ, Jonsson BH, Humble MB. The potential of nutritional therapy. Science (New York, NY). 2010;327(5963):268.Rucklidge JJ, Blampied N, Gorman B, Gordon HA, Sole E. Psychological functioning 1 year after a brief intervention using micronutrients to treat stress and anxiety related to the 2011 Christchurch earthquakes: a naturalistic follow-up. Hum Psychopharmacol. 2014;29(3):230-43.Rucklidge JJ, Andridge R, Gorman B, Blampied N, Gordon H, Boggis A. Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses. Hum Psychopharmacol. 2012;27(5):440-54.Rucklidge JJ, Frampton CM, Gorman B, Boggis A. Vitamin-mineral treatment of attention-deficit hyperactivity disorder in adults: double-blind randomised placebo-controlled trial. The British journal of psychiatry : the journal of mental science. 2014;204:306-15.Kathryn A. Darling, Matthew J.F. Eggleston, Hannah Retallick-Brown, and Julia J. Rucklidge. “Mineral-Vitamin Treatment Associated with Remission in Attention-Deficit/Hyperactivity Disorder Symptoms and Related Problems: 1-Year Naturalistic Outcomes of a 10-Week Randomized Placebo-Controlled Trial” Journal of Child and Adolescent Psychopharmacology 25 Jul 2019 doi.org/10.1089/cap.2019.0036Link to even more studies https://www.hardynutritionals.com/studiesDr Traster video https://youtu.be/nYiOG1Re4X4

References:Misunderstood Lactate Dr George Brooks : The Science and Translation of Lactate Shuttle Theory https://www.ncbi.nlm.nih.gov/pubmed/29617642Comprehensive review on lactate metabolism in human health https://www.sciencedirect.com/science/article/abs/pii/S1567724914000816Heart Rate and Lactate During EnduranceTraining Programs in Rowing and its Relation to the Duration of Exercise by Top Elite Rowers   http://www.worldrowing.com/uploads/files/3Chapter4.pdfDr Rhonda Patrick and Dr George Brooks discuss lactate https://youtu.be/lThFQM503EUDr Andy Galpin on Lactate https://youtu.be/imEsdKxtVyUCarrick Human Performance Program  https://carrickinstitute.com/programs/human-performance-program/Exercise Physiology: Human Bioenergetics and Its Applications 4th Edition  https://www.amazon.com/Exercise-Physiology-Human-Bioenergetics-Applications/dp/0072556420Navigating Metabolism 1st Edition https://www.amazon.com/gp/product/1621821293/ref=dbs_a_def_rwt_bibl_vppi_i0

References:Biochemistry, Aerobic Glycolysis https://www.ncbi.nlm.nih.gov/books/NBK470170/In vivo mitochondrial function in aging skeletal muscle: capacity, flux, and patterns of use. https://www.ncbi.nlm.nih.gov/pubmed/27539499Cancer and Exercise: Warburg Hypothesis, Tumour Metabolism and High-Intensity Anaerobic Exercise https://www.ncbi.nlm.nih.gov/pubmed/29910314Sending the Signal: Muscle Glycogen Availability as a Regulator of Training Adaptation https://www.ncbi.nlm.nih.gov/books/NBK543780/

References:Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313038/Ketone Bodies https://www.sciencedirect.com/science/article/pii/B012227055X006635Respiratory quotients lower than 0.70 in ketogenic diets https://www.researchgate.net/publication/15813523_Respiratory_quotients_lower_than_070_in_ketogenic_dietsDecreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration https://www.ncbi.nlm.nih.gov/pubmed/16188909https://journals.lww.com/nsca-scj/Abstract/2017/02000/A_Case_for_and_Against_Ketogenic_Diets_in_Athletes.7.aspx

References:Volek FASTER tudy   https://www.ncbi.nlm.nih.gov/pubmed/26892521Understanding the factors that effect maximal fat oxidation https://www.ncbi.nlm.nih.gov/pubmed/29344008

References:Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease  https://www.ncbi.nlm.nih.gov/pubmed/29697773Metabolic Flexibility in Health and Disease https://www.ncbi.nlm.nih.gov/pubmed/28467922Metabolic Flexibility in Cardiac Tissue https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999753/Loss of Metabolic Flexibility in the Failing Heart https://www.ncbi.nlm.nih.gov/pubmed/29928647

Well, today marks the final episode in our week on this awesome study in Costa Rica. I'll be sharing with you my top finding from the study... and it's a good one. Visit www.flexdiet.com. Finally, understand nutrition on a whole new level. The Flex Diet Certification only opens 4x a year. Get on the waitlist to get notified for the next class.