Ron Kastner experienced what he called a "mortality moment" in his late 50s. A new dad, with two young daughters, it was a "profound realization" that he was entering the third act of his life and that to make the most of it, he had to make significant changes. A businessman who drank too much and was challenged by the stresses of the corporate world, Ron embarked on a journey to discover the life he wanted to live. He embraced new practices for health and longevity and discovered that it was possible to be fitter, stronger, more energetic, more grounded and happier than ever before. Now in his mid 70s, he says: "The feeling of being alive is just so visceral and so joyous....the wonder, that is our bodies, is just like a ceaseless source of amazement for me."Ron shares his story in the book, A Life Yet to Live: Finding Health, Vitality and Joy. In this interview he reveals the backstory to his transformation - becoming a father at an older age, significant lifestyle changes, such as exercising regularly, adopting a healthier diet, abstaining from alcohol, and an holistic approach to longevity that encompasses both physical and emotional health. Read a transcript:  LLAMA podcast website-Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. -Hampton FitnessMovement & resistance training have long been associated with living a long, healthy life - along with a balanced diet and good sleep. Which is why we're delighted to be working with Hampton Fitness to provide a 15% discount on essential workout gear. Use code: llamapodcast15 at checkout- PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

By Peter BowesI lost a dear friend last week. In fact the UK, my home country, lost a national treasure.Steve Wright was much more than a DJ on the radio. He was a wonderful communicator, entertainer and soul-mate. He was everyone's pal during more than four decades on the air and was the best at what he did. Millions tuned in to his shows but it was Steve's kindness away from the studio and his friendship over the past 30 years that I will forever cherish.This is a podcast about living as long as possible while enjoying the best life we can. Steve's death, at the age of 69, was sudden and has been hard to come to terms with.This episode is devoted to his memory.Joining me, once again, is Peter Allison. We were friends at school in North East England 50 years ago. Mid-life we lost touch but thanks to social media we now talk regularly and for the past few months have been sharing our thoughts about life, fitness and aging through this podcast.We share a common interest in the science behind human longevity and the lifestyle interventions that could help us live longer and better. We review the latest research, media stories and personal hacks in pursuit of a long healthspan.Peter has also suffered a recent bereavement, with the loss of his mother, just before Christmas. My sincere condolences to Peter and his family.In this conversation we reflect on the loss of loved ones, in the context of this podcast, which at its core, is about living a long, purposeful and fulfilling life. Peter spent much of his life working as a professor of geology in London.  He is an experienced diver and keen to optimize his health and vitality to continue with his physically demanding pastime. Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Coleen T. Murphy, a professor at Princeton University, specializes in genomics and molecular biology and is the author of How We Age: The Science of Longevity. In this wide-ranging interview we discuss the significance of declining cellular repair mechanisms that over time lead to visible signs of aging. Prof. Murphy has a particular interest in reproductive aging and cognitive function during aging, considering the former as an often overlooked aspect that begins midlife. Prof. Murphy also expresses concern about the way longevity science is portrayed and criticizes some researchers for failing accurately to describe the true implications of their work. She says there is a need for honesty and realism from scientists to maintain public trust, especially in the field of aging and longevity where bold claims can often outpace reality. Researchers, she insists, should not over-promise results that science cannot yet deliver. We also address the potential for 'exercise in a pill' while Prof. Murphy argues that without taking care of our planet and its inhabitants, the quest for longevity loses much of its significance.Discounts & Affiliation disclosure: This podcast is supported by sponsorship and affiliate arrangements with a select number of companies. The income helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen- PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Are you annoyed by the use of acronyms in longevity science?  Does conflicting advice about diet and exercise drive you crazy?  No wonder we're confused about the best ways to live longer and healthier, when much of the information we receive is contradictory or overly complicated. Brad Inman, founder of Inman News, has spent much of his career staging world class events, focussing on real estate. But now, at the age of 71, the award winning journalist and businessman is turning his attention to health and longevity.  Motivated by a desire to continue his enjoyable and fulfilling life - along with a frustration about a lack of accessible information - Inman is launching a new event to try to demystify longevity science. The Live Long and Master Aging podcast will join some of the world's leading experts at the two-day summit in Palm Beach, Florida, in March.  In this interview, a co-production with Livelong Media™, we unravel Inman's mission to bring transparency and simplicity to the longevity space. How should we explain complex research findings, so that everyone can benefit from it? And who can we trust? The Livelong Summit will take place at the Palm Beach Convention Center in West Palm Beach, Fl., on March 15th and 16th.  The event is open to everyone, offering in-person access to leading experts, with the goal of challenging and explaining the latest innovations.  Our conversation ventures beyond his personal journey and grapples with the complexities of credible information about aging research.  We explore how Brad's mission, at the heart of the Live Long Summit, could herald an era where longevity science echoes in every household, emboldening people from all walks of life to stay healthy for longer.The Livelong Summit will take place at the Palm Beach Convention Center in West Palm Beach, Fl. , on March 15th and 16th.  The event is open to everyone, offering in-person access to leading experts, with the goal of challenging and explaining the latest innovations.  Tickets must be purchased in advance.   We're pleased to share our promo code - LLAMA - to get a 55% discount off passes for all the summit's talks, panels and breakout sessions.   Enter code LLAMA at checkout. Topic covered in this conversation include:* Brad Inman's personal inspiration - how the spirited lives of his parents inspire a discussion about compressed morbidity—the drive to reduce the span of sickness and stretch our days of vibrant health. * Defying the Grim Reaper* The systemic barricades - those within the medical establishment that stifle clear communication and patient empowerment. * The overuse of acronyms and complex terminology in the medical field.* Why clarity and education are vital for patient care. * The Livelong Summit where speakers are thoroughly vetted and curated for PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Deborah Maragopoulos, a nurse practitioner and self-described intuitive healer, believes health and longevity starts with the hypothalamus region of the brain. In her book, the Hypothalamus Handbook, she bridges the gap between traditional medicine and complementary therapies, revealing how a blend of botanicals, nutraceuticals, and intuition not only works alongside evidence-based medicine but can profoundly impact our health. Deborah, a past president of the California Association of Nurse Practitioners, is the founder of Genesis Health Products, Inc. and creator of the nutraceutical supplement, Genesis Gold®. In this interview, we travel through the body's complex systems, controlled by the hypothalamus, and explore the role this part of the brain plays in every day health and wellbeing.Deborah discusses the power of targeted nutrients and her own botanical formulations, for rebalancing our body's systems. She recounts patient stories, emphasizing the importance of early detection of hypothalamic imbalances that could be the key to longevity and a 'harmonious life.' Check out Genesis Health products, hereWatch the interview at YouTube PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

It is that time of the year when we are all acutely aware of the importance of our immune system. But it's about more than catching a winter cold. The health of our natural defense system is crucial to long-term health. Dr. Nicola Vannini is a researcher in the Department of Oncology at the University of Lausanne, in Switzerland.  In this conversation we discuss new research that suggests dietary supplementation with Urolithin A could help boost the immune system. The study (in mice) suggests the compound, which targets mitochondria, is able to reverse the decline in hematopoietic stem cells, which play an essential role in blood health. Could these findings offer hope to older adults as they experience a decline in the efficiency of their immune system?READ THE PAPERInduction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems (Nature Aging)Watch the interview at YouTubeThis interview includes: Recap of urolithin A and its role in promoting metabolic fitness and reducing the accumulation of waste in the cells. Discussion of hematopoietic stem cells and their decline in function with age. Description of Vannini's research on urolithin A and its effects on hematopoietic stem cells in two sets of experiments: ex-vivo and in mice. "Astonishing" results of the experiments, showing that urolithin A treatment improved the function of old hematopoietic stem cells to match that of young stem cells, and enhanced immune response in mice. Potential applications of urolithin A in reversing immunosenescence and improving immune function in elderly individuals and cancer patients who have undergone chemotherapy. Broad impact of urolithin A on various organs and diseases due to its effects on the immune system. Discussion on the role of exercise and nutrition in conjunction with urolithin A supplementation for overall metabolic health. Positive response from the scientific community to Vannini's research and the potential of urolithin A. RELATED EPISODES▸ Dr. Anurag Singh - Chief Medical Officer, Timeline NutritionBoosting strength, stamina and skin health▸ Dr. Davide D'Amico - Research and Development Group Leader, Timeline NutritionHarnessing nature for better human health▸ Dr. Chris Rinsch - co-founder Amazentis (Timeline parent company) Unlocking the power of advanced nutrition▸ Prof. Patrick Aebischer - Chairman & Co-Founder, Amazentis: A novel molecule to promote longevity▸ Dr. Anurag Singh - Chief Medical Officer with AmazentisPomegranates, muscle mass and healthy aging▸ Dr. Navindra Seeram: The rejuvenating power of plants▸ Prof. Johan Auwerz: The exciting potential of human longevity: ▸ Stephanie Blum: Marketing the science of wellbeing Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The podcast explores the role of Urolithin A in improving muscle strength, skin health, and immune system protection. It delves into the research behind Urolithin A and its potential in slowing down aging. The conversation covers the importance of precision nutrition, individual nutrient levels, and the challenges of finding specific probiotics. The episode discusses the progress made with Mitopure, anecdotal evidence in scientific research, and the benefits of a supplement for boosting mitochondrial health. It also introduces a topical product focused on improving skin health through enhanced mitochondrial function.

The Next Chapter Peter Allison and Peter Bowes – school friends 50 years ago - discuss science-based lifestyle interventions as they pursue the next chapter.  Peter A. has spent much of his life working as a professor of geology in London.  He is a keen diver and keen to optimize his health and vitality to continue with his physically demanding pastime. Peter B. is a journalist and broadcaster with a longtime interest in the science of healthy aging and the hacks we can employ to live life to the full, for as long as possible.In regular conversations they review the latest data that could help us achieve a longer healthspan.  This episode includes:- A study from the University of Barcelona that found a Mediterranean diet rich in healthy fats was associated with reduced cognitive decline in older adults. A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three-City Cohort StudyMolecular Nutrition Food Research journalPublished: 24 October 2023- The study used biomarkers in blood tests to confirm dietary habits, providing more reliable evidence than self-reported diaries.- Potential systemic bias in self-declarations of exercise and diet habits.- The impact of positive mindset on healthy aging, referencing a study that found those with positive beliefs about aging lived longer and had lower blood pressure.People who think positively about getting older often live longer, healthier lives. Here is how to reconsider your perspective.Published:  20 September, 2023- And finally: The centenarian sisters who embrace modern technology and emphasize the importance of movement.Centenarian sisters celebrate life togetherPublished: 22 November, 2023 PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

As a teenager Chris Mirabile developed a "humble appreciation of life" that turned into a life-long dedication to biohacking and self-experimentation.   He survived a brain tumor at the age of 16 - an experience that piqued his interest in longevity research and eventually to the launch of NOVOS, a nutraceutical company that targets the biological causes of aging to increase longevity.  An appreciation of science and peer-reviewed research has seen Chris emerge as a leading voice in the pursuit of healthy aging and longevity. In this interview we cover:Recovering from a brain tumor - Chris's lightbulb moment.Evolving interest in human longevity - seminal article Cell - Hallmarks of AgingHow an invincible attitude as a teenage morphed into a humbling appreciation of lifeTacking the US Marine Corps benchmark for fitnessNurturing an interest in biohacking through citizen science and self experimentationThe lifestyle interventions to make the biggest impact on healthThe value of strong healthy relationships and social tied to the communityHow our definition of moderation (in everything) is shifting and changingThe value of recovery over pushing too hard to achieve optimum fitnessAdding a billion years of healthy life to humanityHow longevity plays a role in how your lookClarifying the differences between biological and chronological ageRead a transcript:  LLAMA podcast website-Affiliation disclosure: This podcast receives a small commission when you use the code LLAMA for purchases from companies below which support our mission.   It helps to cover production costs and ensures that our interviews, sharing information about human longevity, remain free for all to listen. - PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

To what extent do genetics play a role in our ability to live a long healthy life? It is one of the many questions that doctors at the Swiss medical spa, Clinique La Prairie (CLP), consider when assessing someone's state of health and potential longevity.  The clinic adopts a holistic approach to wellbeing - balancing the impact of inherited predispositions to certain conditions, the role of epigenetics - the environment we live in - along with lifestyle factors that also have a powerful impact. To explore these and other issues, LLAMA's Peter Bowes traveled to Montreux in Switzerland to meet CLP's Medical Director, Dr Adrian Heini.  YouTube | LLAMA website: transcript & show notesThis episode is produced in association with Clinique La Prairie with whom the LLAMA podcast shares a common goal of helping people pursue a long healthspan.  The pioneering health and wellness destination, nestled on the shores of Lake Geneva in Montreux, Switzerland, combines preventative medicine with bespoke lifestyle and nutrition plans, and offers a holistic approach to living fuller, healthier, and longer lives.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.