Live Long and Master Aging

We are all used to feeling younger than our years and occasionally older than our birth date would suggest.  In effect, we have two ages - chronological and biological. Chronological age simply states the number of years that we have been alive, whereas biological age is a measure of how well our bodies are performing, in relation to the rest of the population.  So how is it determined?  LLAMA host Peter Bowes delved into the science with Elysium Health, which has developed Index, a DNA test that tracks how fast we have been aging, based on our epigenome, which regulates the way genes work.  In this episode, Peter meets Dr. Morgan Levine, an assistant professor of pathology at Yale School of Medicine and an advisor to Elysium Health. They discuss the background to Index, its use of epigenetic clocks to put a number to our biological age, as well as the test's accuracy and implications for healthy living. Recorded: April 21, 2021 | Read a transcript and show notes at the LLAMA podcast website. Topics covered in this interview include:Defining biological age and chronological age. Age as a risk factor for death and diseaseHaving an older parent and developing an interest in aging A lack of consensus over what exactly is meant by aging.How much of aging can be defined as damage to the body, at a cellular level, as we grow older?How do we measure biological age?  Genes, genomes and the epigenome.Developing systems that determine biological age based on epigenetic clocks.Exploring the Index epigenetic, at-home saliva test, to determine biological age.    Privacy concerns related to sharing personal medical information.  Revealing Peter's biological versus chronological age. What does it mean? Interpreting the test results and taking action based on the findings.Does the test reveal information specific to potential medical conditions?How do doctors - primary care physicians - respond to the information gleaned from such tests? The paradigm shift from disease treatment to interventions that delay illness. Lifestyle interventions that promote a long, healthy life.  The reliability of biological age tests. Do repeat tests over a short space of time generate the same results? To what extent do results vary between young and older people? Lifespan and healthspan aspirations. Disclosure: For review purposes, Elysium Health provided Peter Bowes with an Index test kit, free of charge .This episode is brought to you in association with Clinique La Prairie, the award-winning spa-clinic and pioneering health and wellness destination - nestled on the shores of Lake Geneva in Montreux, Switzerland. Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La Prairie offers a holistic approach to living fuller, healthier and longer lives.The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Some of the world's healthiest people spend little or no time pondering their propensity to live a long life.  They just do it. Their lifestyles are a model for longevity. There is much we can learn from these vibrant populations, in countries such as Italy, India, Japan, and (even) parts of the United States.  In this episode of the LLAMA podcast with Peter Bowes, filmmaker Daniel Kennedy discusses his quest to better understand global food and ancient healing traditions. Daniel's documentary series, Healthy Long Life, is an exploratory journey around the globe and considers the discrepancy between lifespan and healthspan; he asks why, for many people, the final years of life are spent in sickness and pain and shares observations about spirituality, mealtime traditions and chronic diseases. Recorded: April 19, 2021 | Read a transcript and show notes at the LLAMA podcast website.Topics covered in this interview include:Filming Healthy, Long Life over four years and Daniel's motivation behind the project Lifespan vs healthspan and what it means for our children and grandchildrenAre chronic diseases pre-determined?  Searching for answers. Deriving inspiration from people with cancer to help others avoid the diseaseMeeting physicians who use plants as medicine, including T. Colin Campbell, the author of the China Project Pinpointing the world's longevity hotspots and learning from ancient healing traditions Fighting illness or promoting health? Plant based diets and the risk of contracting cancerScience, spirituality, food and faith The long lives of Seventh Day Adventists from Loma Linda, CaliforniaThe idea that "genetics may load the gun but it's diet and lifestyle that pull the trigger."The relative benefits of a healthy dietary regime and a life full of physical activity. Is there a French paradox - wine, cheese, butter and good health? Portion size and caloric restriction.This episode is brought to you in association with Clinique La Prairie, the award-winning spa-clinic and pioneering health and wellness destination - nestled on the shores of Lake Geneva in Montreux, Switzerland. Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La Prairie offers a holistic approach to living fuller, healthier and longer lives.The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The science of aging is so infinitely fascinating that Dr. Sandra Kaufmann decided to immerse herself in the field, as a hobby. A pediatric anesthesiologist from Florida, Dr. Kaufmann, is also an athlete who manages to fit swimming, running and rock climbing around her busy hospital schedule.  Determined to enjoy physical activity for as long as possible, she decided to carry out an extensive review of the scientific literature, to better understand our bodies as we grow old.  She focussed on the mechanisms of aging at a cellular level and set out to sort fact from fiction when it comes to the substances or interventions that might help us age more slowly.  The result is, The Kaufmann Protocol: Why We Age and How to Stop It, a book in which she sets out seven key tenets to maintaining optimum health. In this LLAMA podcast conversation, with Peter Bowes, Dr Kaufmann  explains everything from the importance of mitochondrial health and the maintenance of metabolic pathways, to her live and let live attitude towards eating a donut a day. In this interview we cover:Setting the bar high to "overcome all aging"The most ornate out-of-control hobby anybody can haveA light-bulb moment having off a cliff. Is it selfish to focus on the science of 'stopping' aging?Becoming a human guinea pig to try to figure out why cells age. Nurturing the seven protocolsDebunking myths - or ideas behind grandma's remedies - about interventions to slow down the aging processJunk food, including a donut a day.  Really? Being an exercise junkieBiohacking: striving to improve what we are, but is the term realistic? Feeling like a teenager at 52This episode is brought to you in association with Clinique La Prairie, the award-winning spa-clinic - and pioneering health and wellness destination - nestled on the shores of Lake Geneva in Montreux, Switzerland. Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La Prairie offers a holistic approach to living fuller, healthier and longer lives.The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Embracing science and a holistic approach to living a healthier life, has been a hallmark of the Swiss spa-clinic, Clinique La Prairie (CLP), for the past ninety years. Known for its signature treatment, cellular therapy, the medical center opened in 1931, under the guidance of  Dr Paul Niehans, an early expert in the field. Today, CLP melds cutting edge technology with a mission to help people optimize their healthspan, though advanced clinical and wellness programs. The LLAMA podcast is teaming up with CLP to discuss the big issues surrounding human longevity. In this episode, Peter Bowes is joined by C.E.O. Simone Gibertoni and Medical Director, Dr. Adrian Heini.  In a wide-ranging conversation they cover the clinic's history, scientific developments, including Epigenetic screening, and the future of wellbeing as a priority in the post-Covid world. Recorded: April 20, 2021 | Read a transcript and show notes at the LLAMA podcast website.Topics covered in this interview include:Clinique La Prairie's 90-year legacyThe history of a medical spa that melds science and luxury relaxation The scientific gatekeepers monitoring the science behind health and wellness programs Using natural tools to curate a holistic approach to living better and longerDevelopments in genetics and epigenetic tests to reveal predispositions to certain conditionsTailored  programs to focus on conditions such as oxidative stress and inflammationPlants, herbs and fatty acid profilesThe lifestyle trails that influence longevityPersonalized healthy living programs and the four pillars for longevityChanging lives and following up to ensure long-term healthWhy there is no "magic pill"Mindfulness, meditation and bespoke physical exercise modifications The eye-opening impact of Covid on the business of wellness and the long term implications for healthcareThe lasting impact of a week's intensive therapies?Implementing  long-term health programs though CLP hubs around the world. The importance of lifestyle changes and work/life balance. Morning routines and daily health. Taking the long view and imagining the wellness conversation for decades to come. “This episode is brought to you in association with Clinique La Prairie, the award-winning spa-clinic - and pioneering health and wellness destination - nestled on the shores of Lake Geneva in Montreux, Switzerland. Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La Prairie offers a holistic approach to living fuller, healthier and longer lives.”The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The art of growing old, gracefully and purposefully, preferably in rude health, is unique to us all. The journey, with its many twists and turns, involves myriad emotions, adventures and challenges. But Kathleen O'Brien says the process has been somewhat hijacked by society's growing disrespect for the elderly. In her book, Reclaim Your Right To Grow Old, the American writer and broadcaster explores the history of attitudes towards aging and suggests that society's fevered quest for longevity is misguided.  In this LLAMA podcast conversation with Peter Bowes, Kathleen argues that the happiness to be found in aging is being undervalued; that the eccentricities of older people should be celebrated and the joy of smelling the roses more often enjoyed. Recorded: April 12, 2021 | Read a transcript and show notes at the LLAMA podcast website.Topics covered in this interview include:Kathleen's voice was once very familiar to Americans  - how come? Approaching the "sad ride on the down slope" and discovering a new way to look at aging. Exploring the history of aging and the attitudes of ancient cultures, especially towards 'elders.'What the location of graveyards tells us about changing attitudes towards older people and deathIs 'keep busy, keep active' necessarily a positive message, as people age. The 'reclaim your right to grow' old philosophyEmbracing the eccentricities aging - being free to be who we want to be. Smell the roses and worry lessDeath anxiety, spirituality and changing attitudes as we ageThis episode is brought to you in association with JUVICELL, the all-in-one longevity supplement that contains 10 key ingredients shown to have a positive impact on healthspan, as validated by scientific studies. To find out more, visit juvicell.comThe Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor. PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

There has been "spectacular" progress in recent years in the understanding and treatment of Alzheimer's.  The progressive disease, which is the most common cause of dementia, a late-in-life decline in memory and cognitive ability, afflicts 50 million people around the world. Taking family members and other carers into account, that number increases exponentially.  The condition, for which there is currently no cure,  amounts to a modern day crisis, for all involved. In this episode of the LLAMA podcast, Dr Jason Karlawish, a gerontologist and professor of medicine and medical ethics and senior fellow of the Center for Bioethics at the University of Pennsylvania, says significant gains are being made with therapeutic treatments, but many hurdles remain.  The author of The Problem of Alzheimer's: How Science, Culture and Politics turned a Rare Disease into a Crisis, also argues that Alzheimer's is disease of our identity and a condition that raises fundamental, moral questions about what it means to lead a good life. Recorded: March 30, 2021 | Read a transcript and show notes at the LLAMA podcast website.Topics covered in this interview include:The difference between dementia and Alzheimer's disease.How can dementia be distinguished from the 'normal course of aging?"The work of the Penn Memory Center, with patients and their loved ones. Explaining medicine in the 'real world,' through the stories and experiences of people.Why patients and caregivers are the best teachers. Distinguishing between disease and disability. How stigma haunts the lives of people with dementia. Defining Alzheimers as once a rare disease, now a crisis. The "spectacular progress in science," dealing with Alzheimer's. "Living' with Alzheimer's rather than relying on drugs. Why is the risk of demential declining? The crisis of good quality care for Alzheimer's patients in the U.S.Regular exercise and a heart healthy diet to maintain good brain health.  Red wine too? This episode is brought to you in association with JUVICELL, the all-in-one longevity supplement that contains 10 key ingredients shown to have a positive impact on healthspan, as validated by scientific studies. To find out more, visit juvicell.comThe Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Turning fifty can be a wrenching experience for some people.  Others discover that it is their sixtieth birthday that conjures up disturbing emotions. There is no doubt that big birthdays focus the mind on the aging process and what is often described as a midlife crisis.  But should we fear the passage of time?  Lisa Levine is a life coach and the author of Midlife No crisis, an insightful and entertaining exploration of the years that signpost our lives.  In this LLAMA podcast conversation with Peter Bowes, Lisa explains why we should embrace "transformative" periods, instead of dreading them, and how the advancing years can propel us in a "more fulfilling direction," with excitement and optimism. Recorded: April 5, 2021 | Read a transcript and show notes at the LLAMA podcast website.Topics covered in this interview include:When does mid-life happen and why is it associated with a crisis for some people.Pre-empting a mid-life crisis When the meaning  of life becomes more important that just doing a job. The difference between turning 50 and 60?Leaving Hollywood and the entertainment business for a new calling - something deeper with more meaning. Becoming a life coach and "walking the talk." Dealing with health obstacles and fertility issues and discovering alternative therapies. Do men and women face the same mid-life issues? How our backgrounds and life experiences mold our lives and attitudes toward aging. Discovering the perks on midlife, wisdom and putting space between negative thoughts.The value of friends and community in dealing with the aging process - knowing that you're not alone. Social media - compare and despair. Avoiding the rabbit holes. The privilege that is aging. This episode is brought to you in association with JUVICELL, the all-in-one longevity supplement that contains 10 key ingredients shown to have a positive impact on healthspan, as validated by scientific studies. To find out more, visit juvicell.comThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor. PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Living life to the full, at any age, has been a challenge recently.  To put it mildly.  But if Covid has taught us anything, it is that some of life's simplest pleasures are what make life itself worth living. Therein lies a metaphor for healthy aging.  Physical fitness, social contact and an active mind go a long way towards helping us live longer and better.  They are also central to the ideals of Aging is Cool, a Texas-based company that helps people over fifty stay active and engaged as they age. In this LLAMA episode, Aging is Cool co-founder, Amy Temperley, explains why she rails against a modern-day culture rife with ageism and how she hopes to redefine what it means to grow old. "Old is a feeling and I don't know that you're old until you decide that you're old," she says.  In conversation with Peter Bowes, Amy also reveals how life with Covid has opened her eyes to the everyday activities that bring pleasure and purpose to life. Recorded: March 22, 2021 | Read a transcript and show notes at the LLAMA podcast website.Topics covered in this interview include:Targeting healthy, active aging and coming up with the idea for Aging is CoolRealizing that aging can be positive, celebrating a robust zest for life and it is okay to get older.  Is there a benchmark for becoming oldAnti-aging versus finding a sense of purpose in life. Building a company focussed on mind and body training for older adultsA Mighty Good Time -  a one-stop-shop and mostly virtual resource for adults aged 50+Over fifty - is there a mindset change? Reducing social isolation through involvement in a communityThe value of friendship and forging new relationshipsSocial interaction post Covid and find new joy-inducing pastimes. How making stuff can be fun. Advocacy for the benefits of a healthy, aging population. Breaking out of Covid, socializing more and multi-generational friendships. Morning rituals that include caring for dogs. Finding those things that make life worth living - "embracing the things you love rather than lamenting what you've lost."This episode is brought to you in association with JUVICELL, the all-in-one longevity supplement that contains 10 key ingredients shown to have a positive impact on healthspan, as validated by scientific studies. To find out more, visit juvicell.comThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor. PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Cracking the code behind aging has long since fascinated, frustrated and captivated scientists.  In our quest to live longer and better, a desire to fully understand the mechanisms that explain how and why we grow old, has been central to longevity research. In recent years some significant progress has been made. A clearer picture is emerging of the changes that occur, at a cellular level, that could dictate how our bodies respond to the passing years. In this episode of the LLAMA podcast, Prof. David Walker, a researcher at the University of California, Los Angeles, (UCLA) discusses his work with tiny worms and fruit flies, and explains the significance of myriad age-related issues, such as dysfunctional mitochondria, leaky intestines and inflammation. Recorded: March 2, 2021 | Read a transcript and show notes at the LLAMA podcast website.Disclosure: Prof. Walker is a member of the scientific board of JUVICELL, a sponsor of this LLAMA podcast episode. Topics covered in this interview include:Dr. Walker's academic journey from Belfast to Manchester and Los Angeles. Inspiration through  Jonathan Weiner's Time, Love Memory - a biography of Seymour Benzer, the biologist renowned for his study of genetics through experiments with fruit fly genes.  Working with nematode worms and fruit flies.  Aging - a great scientific mystery.  How our understanding of what is driving aging, at a cellular level, has evolved. Developing novel ways, using genes, to prevent age- related health decline.  Changing awareness of aging as we grow older.Accumulation of dysfunctional mitochondria and how it appears to be an important cellular hallmark of aging. The importance of autophagy for maintaining cellular health.Why do we age at different rates?  The pathophysiology of aging: How do age-related changes that affect organ function, relate to the health and viability of the aging organism?    Leaky intestines in fruit flies and humans . Inflammation and the link to age-onset diseasesGut bacteria and relevance to various diseases and health interventions. Diet and variability of our gut microbiome.High/low  protein diets and the aging gut, based on fruit fly studies.  Does eating less protein enhance longevity? Making better informed decisions about diet and dietary supplementation. Practicing "  common sense" lifestyle goals. Exercise and everyday diet    to counter the effects of aging. Memory loss  as we age and a better understanding of the mechanisms involved based on studies with fruit flies. Lifestyles focussed on living life to the full.This episode is brought to you in association with JUVICELL, the all-in-one longevity supplement that contains 10 key ingredients shown to have a positive impact on healthspan, as validated by sFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Baby boomers make up a significant portion of the world's population.  In the US and the UK the generation born between 1946 and 1964 represents about a fifth of all people and is a hugely influential group.  So what's it like to be a boomer in 2021?  Many are still working, physically active and important contributors to the economy.  Others are retired and enjoying the fruits of their careers, while some are facing up to the challenges of life as a septuagenarian.  "My almost fervent, religious conviction is we can all do better," says Dave Frost, a decorated naval officer,  world-ranked oarsman and Master Fitness Trainer.  Dave was born in 1953. The San Diego-based author of KaBoomer: Thriving and Striving into Your Nineties is the founder of Well Past Forty, a company that promotes wellness and fitness for athletes of all ages and abilities. In this LLAMA podcast interview, with Peter Bowes, he discusses his gregarious approach to life, ambitious athletic goals and plan to "live large" into his tenth decade. Recorded: March 16, 2021 | Read a transcript and show notes at the LLAMA podcast website.Topics covered in this interview include:What is it like to be a baby boomer in 2021?Dave's definition of the "encore" years and what it means to live in the "best act yet" of our lives. Living through the bottom of the happiness curve.Figuring out the daily activities, including motion and purpose, that enhance life. The life-changing impact of 911. Embracing the Loma Linda, low stress, outdoor lifestyle, for longevity. The importance of breathing for everyday health and good sleep. The joy of distance running and how the runner's high can be achieved with alternatives forms of exercise, as we get older. The value of exercise, quiet time, mind-body alignment  and "living large" as we age into our nineties. "We know aging is unavoidable, but we don't have to get old."This episode is brought to you in association with JUVICELL, the all-in-one longevity supplement that contains 10 key ingredients shown to have a positive impact on healthspan, as validated by scientific studies. To find out more, visit juvicell.comThe Live Long and Master Aging podcast shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor. PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts   SpotifySupport the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.