This Week in Startups

Jason Calacanis
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87 snips
May 23, 2025 • 1h 5min

Apple’s Tariff Trouble, Anthropic’s New Models, and Our Founder Friday Finale | E2130

Unpack the implications of a potential 25% tariff on Apple and how it reflects the political landscape. Discover Anthropic's new Claude models, which are setting new standards in AI and coding performance. Also, witness an exciting showdown in the Founder Fridays competition, where two innovative startups compete for supremacy. Plus, a light-hearted dive into the unexpected world of smart toilets and their role in gut health. It's a fast-paced exploration of startups, technology, and the challenges they face today.
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177 snips
May 22, 2025 • 41min

David Friedberg on AI-First Startups & the Future of Biology, Business & Creativity | AI Basics with Google Cloud

David Friedberg, CEO of Ohalo Genetics and co-host of the All-In Podcast, dives into the revolutionary impact of AI on agriculture and startups. He introduces 'Boosted Breeding' technology that promises to double crop yields. The conversation explores building AI-first companies and the possibilities of genome language models. Friedberg also discusses how AI democratizes creativity, enabling personalized storytelling experiences and paving the way for an 'Age of Abundance' in resources like food and energy.
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149 snips
May 21, 2025 • 1h 5min

Jony Ive Joins OpenAI, Waymo Hits 10M Rides, and How to Launch a Marketplace from Scratch | E2129

Discover the implications of Jony Ive's $6.5 billion deal with OpenAI and the merging of design with AI technology. Dive into Waymo's achievement of 10 million rides and how it stacks against Tesla's robotaxi plans. Delve into the complexities of stablecoin regulation under the GENIUS Act, and learn gritty tactics for launching a marketplace from scratch. The ethical debates surrounding AI-powered smart glasses also take center stage, raising questions about privacy and technology's future.
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71 snips
May 20, 2025 • 1h 4min

Drones, Design, and Digital Espionage | E2128

Parth Mahendru, co-founder of Prantl and expert in non-lethal drone deterrence, discusses revolutionary ultrasonic technology that neutralizes drones without causing harm. The conversation dives into the legal gray areas surrounding drone defense over private property and unpacks the corporate espionage feud between Rippling and Deel. They also explore how startups can leverage world-class design and ethical AI practices to enhance productivity and innovation in an ever-evolving tech landscape.
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163 snips
May 16, 2025 • 1h 4min

Microsoft Layoffs, Immigration Blunders, & Office Hours with Jeremy Redman of Airfive | E2127

Jeremy Redman, founder of Airfive, shares insights on the recent Microsoft layoffs amidst record profits and how it reflects a new tech industry landscape. The discussion dives into the vital role of skilled immigrants in driving innovation and the consequences of tightening immigration policies. Redman also introduces his novel prepaid SaaS model for customer support automation, addressing challenges in traditional pricing strategies. The conversation highlights the evolving dynamics of AI in the startup ecosystem and the importance of adapting revenue models to meet customer needs.
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60 snips
May 15, 2025 • 1h 7min

Chime’s IPO, Databricks’ $1B Acquisition & Dave Rubin’s Media Empire | E2126

Dave Rubin, a prominent political commentator and host of The Rubin Report, dives into the challenges and triumphs of building Locals, an independent creator platform. He shares insights on why he goes phone-free for weeks and the detrimental effects of identity politics on business and sports. The conversation also touches on the fast-evolving landscape of right-wing media and the need for mental health breaks. Rubin advocates for innovative subscription models in the entertainment sector, while exploring generational tensions amidst a polarized cultural landscape.
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192 snips
May 13, 2025 • 52min

Agentic AI Meets Cybersecurity + Solar Robots in the Desert | E2125

Aaron Walls, founder of ZioSec, discusses their pioneering work on cybersecurity for AI agents, emphasizing the importance of proactive testing to preemptively address vulnerabilities. Matt Campbell from Terabase highlights how mobile robotic factories are revolutionizing solar energy deployment, allowing massive solar farms to be built directly in the desert. Together, they explore the synergy between advanced technologies and renewable energy, both critical for a sustainable future.
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59 snips
May 13, 2025 • 1h 31min

Anti-Work Uprising, Copyright Wars & the StreamFog Solution | E2124

In a fiery discussion, the hosts debate the anti-work movement and its implications for the future of labor. They explore the alarming statistics surrounding startup funding, particularly the challenges in moving from seed to Series A. Excitingly, a new AI rights licensing platform is introduced, aiming to protect creators in the evolving copyright landscape. The conversation shifts to the high-profile valuation of Perplexity and discusses the potential impact of geopolitical forces on the tech sector, particularly regarding antitrust issues and the role of big companies.
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80 snips
May 10, 2025 • 1h 13min

OpenAI Scoops Instacart’s CEO, AI in the Courtroom & Off-Road Startups | E2123

OpenAI makes waves by hiring Instacart's former CEO, raising eyebrows in the tech community. The ethical quagmire of using AI avatars in court sparks a heated discussion about the future of legal testimony. Late-stage funding is redefined, proving that a 'Series G' doesn't always mean trouble for startups. Plus, insights from 'The Checklist Manifesto' shed light on the importance of systematic approaches. Lastly, a spotlight on WhereToWheel ignites excitement in the off-road startup scene!
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40 snips
May 8, 2025 • 1h 7min

Zoox Crash Fallout, COATUE’s $1B Open Fund, and Office Hours with FusionAds | E2122

Evan Graj, founder of FusionAds, discusses how AI is reshaping marketing for small businesses by simplifying ad creation. He shares insights on fostering client trust in AI-generated advertisements. The conversation also covers COATUE's new innovative venture fund aimed at democratizing investment access. Additionally, the podcast kicks off with a deep dive into Zoox's recent robo-taxi recall, Uber's impressive earnings, and the vital need for companies to adapt to AI as Fiverr's CEO emphasizes the urgency of embracing automation.

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