Talking Biotech with Dr. Kevin Folta

 The role of Cas9 as an editing/deletion nuclease has been well established, but can it be used to turn genes on?   Dr. Yiping Qi of the University of Maryland has developed a system where Cas9’s specificity is used to recruit gene expression activation factors to plant promoters.  The approach allows activation of sets of genes associated with disease resistance or other useful plant traits.# COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

COVID19 is the spectrum of pathologies caused by the SARS-CoV2 virus.  While the pandemic moves well into its second year, the importance of detection in populations cannot be overstated.  However, testing methods typically include visiting testing centers, and it is hard to find a test that is both rapid and precise.  Dr. Peter Ngyuen is a scientist with the Wyss Institute that has designed wearable sensors to detect specific viruses.  We talk about the amazing synthetic biology technology and how it is now being applied to face masks that can detect the presence of the virus in the breath of someone wearing the mask.  The rapid detection can help guide behavior as well as provide an early detection to potentially seek medical care to minimize long-term health implications.# COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

 Cassava is a staple for one in ten people on earth, grown mostly by small famers tending a few acres. One of the challenges is insect-vectored virus Cassava Brown-Streak Virus that destroys the root.  Scientists from Africa and the Danforth Center in St. Louis MO, USA have collaborated to create a cassava line that is genetically engineered to suppress the virus. The approach is similar to what was done to save the papaya in Hawaii, essentially using a portion of the virus sequence to shut down viral infection. In this week’s podcast Dr. Douglas Miano, Professor at the University of Nairobi, describes the problem and the solution. as well as how the technology may serve farmers in Kenya and the entire African continent.KARLO Website CassavaPlus Website# COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

 He jet-sets around the planet and writes letters to government officials, brandishing academic and military credentials. He speaks with authority as an affiliate of a land-grant university.  His claims rattle audiences and frighten regulators in the Developing World. Dr. Don M. Huber is a Professor Emeritus at Purdue University.  Over the last decade he has taken the point to denigrate agricultural biotechnology and its associated chemistries. Many of his fantastical claims are patently false, such as his discovery of a new life form that was thriving on Roundup herbicide and causing disease in humans, animals and plants. When challenged, he attacks his critics, even resorting to false claims to their employers to silence them.  Still he circles the globe in a Quixotic attempt to end implementation of useful technology. What is the motivation?  Why does it continue? Today’s episode analyzes the claims and outcomes with Rob Wager, retired faculty member of Vancouver Island University in Naniamo, Britsh Columbia. Rob has been a remarkable voice in identifying false information and helping correct it, with expertise in the literature and the personalities that push false information agendas. Follow Rob Wager on Twitter: @RobertWager1 Link to Huber’s talk at Plant Animal Genome Conference 2019 (from PAG website; I’m on Page 10). Link to his complaint letter to my employer  (available via public records request)# COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

 The Genetic Literacy Project is a popular science news website.  A diverse set of articles and viewpoints are presented, with original articles and news aggregated from the internet.  Over the last decade the website as been accused of simply being a “front” for the seed industry, even though there is no such tie to these businesses. Such accusations are levied by websites and NGOs that reject the science presented.  A recent expose’ in the Genetic Literacy Project analyzed the organizations and their funding. It turns out that the organizations that criticize the science have intricate direct links to each other, as well as to law firms that have associations with Scientology. The take home message is that the disinformation these groups present is echoed by the other related “disinformation feedback loops” multiple presentations in the media that appear to be independent, but are all part of a connected and intricate scheme to tarnish the perception of actual scientific information, the scientists that produce it, and the outlets that present it. Jon Entine on Twitter: @JonEntine Genetic Literacy Project Website Genetic Literacy Project on Twitter:  @GeneticLiteracy A link to the original story here. # COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

 Jack Bobo has been studying food, farming and the associated psychology for decades, asking questions about the choices people make around food. His recent book Why Smart People Make Bad Food Choices addresses the psychology of value, risk and food choice.Follow Jack Bobo on Twitter :  @Jack_A_Bobo Futurity website here. # COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

We have two major problems.  Vanilla is mostly produced in a narrow set of unstable economies and the supply chains are especially vulnerable.  There is massive demand for vanilla flavoring.  The other major problem is plastic bottles.  Plastic waste from PET bottles creates a massive environmental hazard, and is purely unsustainable.  What if those bottles could be used as a substrate to produce useful compounds, like vanilla flavoring?  Dr. Joanna Sadler asked that exact question and using the tricks of synthetic biology installed the enzymatic steps to convert PET bottles into vanillin, the central compound of vanilla flavoring. A genetically engineered strain of E. coli efficiently converts trash into treasure, and is a great harbinger for the future of synthetic biology in waste remediation. Follow Dr. Sadler on Twitter:  @JoSadler10 # COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

 Analysis of massive genomic DNA sequence data indicates that gene transfer between similar species actually happened, and did so at a surprising rate.  Today’s podcast with Dr. Luke Dunning of University of Sheffield discusses his recent findings that indicate grasses are sharing genes with each other. It is an interesting discussion about horizontal gene transfer, from its mechanism, to its outcomes, to its effect on genetic variation and evolution.Follow Dr. Dunning on Twitter Dunning Lab website# COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

 One of the major objections to genetic engineering is that a DNA segment is transferred to the crop, and lands in a somewhat random location.  That’s because genetic engineering largely uses Agrobacterium to perform the genetic exchange.  But Agrobacterium came from nature, and there is significant evidence that DNA transfer events have been happening for thousands to millions of years.  Dr. Leon Otten has been studying Agrobacterium for decades, and now is identifying recent evidence that the bacterium has littered the plant world with random DNA insertion events. It is likely that these events had important roles in plant evolution, potentially around agronomically important traits. We discuss this natural phenomenon and how it may change the dialog on genetic engineering and regulation.# COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

 Dr. Dan Wilson is a rising star of science communication. His popular YouTube channel Debunk the Funk provides entertaining and evidence-based dissection of issues around science, vaccination and COVID19.  In this issue of the Talking Biotech Podcast we discuss science communication, his motivations, and the recent dissection of the Disinformation Dozen.  We cover recent vaccine disinformation as well as the role of universities and younger scientists in science communication.Follow Debunk the Funk on YouTube here. Follow Dr. Dan Wilson on Twitter here.# COLABRATalking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/# TALKING BIOTECHTwitter: https://twitter.com/talkingbiotechWebsite: https://www.colabra.app/podcasts/talking-biotech/Instagram: https://www.instagram.com/colabrahqThe Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.