Health Longevity Secrets

#009-Stress is now known to affect everything from gray hair to epigenetic age among other things in our health.  Dr Stephen Sideroff beautifully outlines the 9 pillars of resiliency that allow us to handle the inevitable chronic stress in our lives.Please join Dr Stephen Sideroff for this masterclass in human stress management through building lasting resilience. Take away points: -Stress can be both positive and negative. Chronic stress tends to be harmful. -Stress can affect telomeres and other markers for aging-Early childhood experiences can strongly influence how we deal with stress as adults 03:38 Steve's early career in brain research06:04 Failure of longterm results in stress management from single workshop08:24 Early childhood experiences and the primitive gestalt effect on stress14:23 Enhancing neuroplasticity18:00 The path: mastering the nine pillars of resilience24:12 Stress effect on telomeres and markers for aging30:15 Concept of eustress for positive stress from Hans Selye37:23 Key pillars of resilience40:45 Relationship with ourselves, others, and something greater41:52  John M. Gottman ratio of positive to negative couples interactions45:03 Stress as sympathetic nervous system activator48:21 Personal lifestyle choiceshttp://drstephensideroff.com/  *** SUBSCRIBE TO ROBERT LUFKIN MD YOUTUBE CHANNEL HERE ***https://www.youtube.com/channel/UC2w2eKHmcRXuGR8RmTgUv3Q*** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/Twitter:https://twitter.com/robertlufkinmdNOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advicLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdSubstack: https://robertlufkinmd.substack.com Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

#008-The physician with arguably the largest clinical experience in prescribing Rapamycin for longevity talks about the challenges and benefits of this fascinating and controversial practice. Dr Alan Green takes us on a deep dive on the use of Rapamycin for longevity.Take away points: -Rapamycin has extended the lifespan of organisms from yeast, worms, flies, and even middle-aged mice.-In a 2014 paper, rapamycin extended the median lifespan 23% in male mice and 26% in female mice. -It is an FDA approved prescription drug with indications for use for the prevention of organ transplant rejection and for the treatment of lymphangioleiomyomatosis.-The drug requires a prescription and should only be used under supervision of a physician-Rapamycin acts by suppressing the master nutrient sensing protein mTOR [mechanistic target of Rapamycin]02:45 Blagosklonny papers (Blagosklonny 2019)05:23 Jane Mannick rapalogue paper (Mannick 2014)08:04 Cardiomyopathy diagnosis : Apical hypertrophic cardiomyopathy09:14 Elevated mTOR as common factor- Inflammation, fibrosis, 12:03 Rapamycin role to decrease mTOR overview common pathway 14:23 mTOR is essentially command and control of the cell for the last 2 billion years15:00 Mitochondrial complex 1 affected by common pathway by rapamycin, caloric restriction, protein restriction, methionine restriction has universal anti-aging effects16:05 Increased mTOR causes increased innate immune system/inflammation 17:28 2009 paper showed increased mouse lifespan not by just decreasing cancer but most other diseases of aging19:15 Osteoarthritis inflammation improved by decreased mTOR and increased autophagy 23:00 Alzheimer disease as a disease of senescent cells26:00 importance of dose timing for Rapamycin27:00 Anti aging effects on mTOR1 and other effects on mTOR232:00 Rapamycin as off patent drug37:00 Dosing considerations and subjective effects40:00 Tracking HOMA-IR  (Homeostatic Model Assessment for Insulin Resistance) score 42:00 Improvement in exercise related to maximum cardiac output45:00 Age associated cardiomyopathy49:00 Untoward effects- Aphthous ulcers and decreased innate immune system. Be on guard for bacterial infections.57:00 Personal lifestyle choiceshttps://rapamycintherapy.com/ Rapamycin Clinical Registryhttps://wwLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdSubstack: https://robertlufkinmd.substack.com Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

#007-Magnetic resonance or MR  imaging is one of the most powerful noninvasive medical testing tools- and when we combine it with with the emerging power of artificial intelligence great things are possible. Today we are looking specifically at applying this technology to the brain  in order to help understand dementia from one of the leaders in the field. Wiro Niessen is a professor at both Erasmus MC, University Medical Center Rotterdam and Delft University of Technology. He is founder and scientific lead of Quantib, an AI company in medical imaging. He received a master's degree in Physics and a PhD in Medical Imaging from Utrecht University.—2012 ImageNET competition revolutionized machine learning with deep convolutional neural networks-Data science approach to medical imaging-How risk factors [Genetic and lifestyle] are associated with outcome-Rotterdam study for population imaging-Increased deep white matter changes associated with increased stroke and dementia-DTI- diffusion tensor imaging allows white matter tracts to be seen- AI can automate processing to save orders of magnitude in processing time-Automated biomarker extraction from 15,000 Brain MRI-Hippocampal volume- associated with risk for later developing Alzheimer disease. -MICCAI Society- Medical Image Computing and Computer Assisted Interventions-ESR- European Society of Radiology-FAIR- Finable, Accessible, Interoperable, Reusable Datahttps://www.erasmusmc.nl/en/research/researchers/niessen-wirohttps://www.quantib.com/about/team/wiro-niessen*** SUBSCRIBE TO ROBERT LUFKIN MD YOUTUBE CHANNEL HERE *** https://www.youtube.com/channel/UC2w2... *** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA *** Web: https://robertlufkinmd.com/ Twitter:https://twitter.com/robertlufkinmd LinkedIn: https://www.linkedin.com/in/robertluf... *** THINGS I ACTUALLY USE FOR MY OWN HEALTH AND LONGEVITY *** [ROBERT LUFKIN MD AMAZON INFLUENCER STOREFRONT] https://www.amazon.com/shop/robertluf... *** GOT A SUGGESTION FOR A SHOW? *** Contact us at: https://robertlufkinmd.com/contact *** SPONSORSHIPS & BRALies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdSubstack: https://robertlufkinmd.substack.com Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

#006-Epigenetic change is now recognized as the cumulative effect of our life experiences in controlling gene expression. What is less well known is that this epigenetic influence on our gene expression can extend back to our parents’ and even our grandparents’ life experiences. Let's dive into this fascinating topic with todays guest expert.Judith Finlayson is a best-selling author who has written books on a variety of subjects, from personal well-being and women’s history to food and nutrition. Her most recent book ‘You Are What Your Grandparents Ate’ is a revealing take on transgenerational epigenetics and has been translated into German, French, Spanish, Slovenian and Japanese. Key points:-Current understanding - genomic information is transferred but epigenetic information is wiped clean each generation-but not quite so simple. -For example, studies have shown that both the children and grandchildren of women who survived the Dutch famine of 1944-45 were found to have increased glucose intolerance in adulthood.-Other researchers have found that the descendants of Holocaust survivors have lower levels of the hormone cortisol, which helps your body bounce back after trauma.-Mechanisms for transgenerational epigenetics-David Barker- hypothesis-dietary and lifestyle choices she prioritizes to support optimal genetic expression. *** SUBSCRIBE TO ROBERT LUFKIN MD YOUTUBE CHANNEL HERE ***https://www.youtube.com/channel/UC2w2eKHmcRXuGR8RmTgUv3Q*** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/Twitter:https://twitter.com/robertlufkinmdLinkedIn: https://www.linkedin.com/in/robertluf...*** THINGS I ACTUALLY USE FOR MY OWN HEALTH AND LONGEVITY ***[ROBERT LUFKIN MD AMAZON INFLUENCER STOREFRONT]https://www.amazon.com/shop/robertluf...*** GOT A SUGGESTION FOR A SHOW? ***Contact us at: https://robertlufkinmd.com/contact*** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contact NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professioLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdSubstack: https://robertlufkinmd.substack.com Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

#005-Today we learn how diet, genetics, and epigenetics interact with each other to impact our health and longevity, and how to use this information to design personalized lifestyle interventions from a true expert in the field.Dr. Lucia Aronica received her PhD from the University of Vienna and has research experience from the University of Oxford, University of Southern California, and University Federico II of Naples. She is also Lecturer at the Stanford Prevention and Research Center, Genomics Lead at Metagenics Inc., and editor of the peer-reviewed journal Life by MDPI. Take away points: -We get our genetic information from our ancestors while epigenetic information is from our life experiences-Epigenetic change can occur via three mechanisms: 1- small RNA, 2-histone modification, and 3-DNA Methylation-DNA Methylation is currently the best epigenetic modification for detailed epigenetic analysis-First generation DNA methylation clocks (Horvath et al) were chronological clocks, while second generation clocks (GrimAge, etc) tend to be biological clocks trained on specific conditions/phenotype-Chronological clocks are useful in forensic applications-Chronological age can deviate from biological age reflecting varying risk for outcomes-Athletes showing increased biological age may be related to short term inflammatory genes and cytokines for the adaptive stress response to exercise-In Ketogenic diets can see down regulation of excitatory brain pathways as possible mechanism for effects in epilepsy population-Induced pleuripotent stem cells can be produced by transcription factors that reverse epigenetic age-Biologic DNA methylation clocks are very valuable for lifestyle intervention and longevity researchlaronica@stanford.edu https://draronica.com/https://www.youtube.com/user/81luxarhttps://continuingstudies.stanford.edu/courses/liberal-arts-and-sciences/longing-for-longevity-from-biology-to-biohacking/20211_BIO-07 Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, Kraemer HC, King AC. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2007 Mar 7;297(9):969-77. doi: 10.1001/jama.297.9.969. Erratum in: JAMA. 2007 Jul 11;298(2):178. PMID: 17341Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdSubstack: https://robertlufkinmd.substack.com Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

#004-Up to 40% of dementia may be prevented through lifestyle changes [Livingston Lancet 2020]. Let's find out the top six ways to reduce dementia risk with lifestyle from todays expert guest.Sarah McEwen, PhD, is a Cognitive Psychologist with 15 years of clinical research experience, specializing in the study of physical activity and cognitive enhancement interventions to investigate biological, behavioral and health-related outcomes in patients suffering from cognitively debilitating disorders. Dr. McEwen graduated with a bachelor’s degree from the University of California, Davis and a PhD in Psychology from Trinity College.Dr. McEwen serves as Section Editor for the peer-reviewed journal NeuroReport, and Associate Editor for the Journal of Alzheimer’s Disease, and has published over 45 peer-reviewed journal articles. Up to 40% of dementia may be prevented through lifestyle changes [Livingston Lancet 2020]. Neuroplasticity - brain can change throughout life-Physical exercise can actually result in hipoocampal growth on MRI in adults. -Diet- Follow the MIND protocol-Sleep-Reduce chronic stress-MBSR Mindfulness Based Stress Reduction     Hippocampal volumes can increase following MSSR [Holzel 2011]https://wakingup.com/ https://palousemindfulness.com/ -Social IsolationGenius Gyms  (https://geniusgyms.com)Pacific Brain Health Center (https://www.pacificneuroscienceinstitute.org/brain-health/) *** SUBSCRIBE TO ROBERT LUFKIN MD YOUTUBE CHANNEL HERE ***https://www.youtube.com/channel/UC2w2eKHmcRXuGR8RmTgUv3Q*** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/Twitter:https://twitter.com/robertlufkinmdLinkedIn: https://www.linkedin.com/in/robertluf...*** THINGS I ACTUALLY USE FOR MY OWN HEALTH AND LONGEVITY ***[ROBERT LUFKIN MD AMAZON INFLUENCER STOREFRONT]https://www.amazon.com/shop/robertluf...*** GOT A SUGGESTION FOR A SHOW? ***Contact us at: https://robertlufkinmd.com/contact*** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contact NOTE: This is not intended to be Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdSubstack: https://robertlufkinmd.substack.com Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

#003-A new MRI company with a technological twist and a revolutionary vision to transform health and longevity by low cost MR screening for cancer and other diseases. Co-founders Raj Attariwala MD and Andrew Lacy MBA JD describe their fascinating journey and the challenges of early detection of disease. Take away points: -Cancer and other disease are 5-7 times more likely to kill you if detected late.- A late diagnosis of a serious health condition often leads to a much worse outcome.-Conditions such as aneurysms, dementia, stroke risk, IBD, colitis, kidney stones do not have very effective screening tests.-Due to cost pressures in the health system, doctors may be discouraged from investigating low probability diagnoses, even if they have serious consequences for the patient. https://www.prenuvo.com/ https://omronhealthcare.com/products/heartguide-wearable-blood-pressure-monitor-bp8000m/*** SUBSCRIBE TO ROBERT LUFKIN MD YOUTUBE CHANNEL HERE ***https://www.youtube.com/channel/UC2w2eKHmcRXuGR8RmTgUv3Q*** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/Twitter:https://twitter.com/robertlufkinmdLinkedIn: https://www.linkedin.com/in/robertluf...*** THINGS I ACTUALLY USE FOR MY OWN HEALTH AND LONGEVITY ***[ROBERT LUFKIN MD AMAZON INFLUENCER STOREFRONT]https://www.amazon.com/shop/robertluf...*** GOT A SUGGESTION FOR A SHOW? ***Contact us at: https://robertlufkinmd.com/contact*** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contact NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here.Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel.To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channelLies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdSubstack: https://robertlufkinmd.substack.com Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

#002 - I was raised on margarine, diet soda, low-fat milk, and I avoided sugary cereals. We followed the guidelines of the USDA and the Food Pyramid. How did we get it so wrong? Find out as we meet an experienced dietician and high performance athlete who is rethinking the conventional wisdom on nutrition.Michelle Hurn is a registered and licensed dietitian with eleven years of experience as a clinical, acute care dietitian, lead dietitian in psychiatric care, and outpatient dietitian.She is the author of The Dietician's Dilemma-What would you do if your health was restored by doing the opposite of everything that you were taught?Michelle is an avid endurance athlete, she has qualified for the Boston Marathon 12 times, and on November 7th 2020, she recently won her first ultra marathon covering 44.63 miles in a 6 hour timed race.Some of the things we cover:What is a dietician and what do they do?What is the state of modern dietetics? What does the ADA still get wrong today?What are your current recommendations?Optimal diet?Fasting?https://thedietitiansdilemma.net/https://www.robertlufkinmd.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdSubstack: https://robertlufkinmd.substack.com Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...

#001 - It is becoming accepted that most major chronic illnesses are linked by common metabolic/longevity mechanisms that can be influenced by the choices we make in our lives. Let’s use evidence based medicine to inform these choices.  This is a quick first episode of the show where we describe the motivation for the program and a brief overview of the types of experts on health and longevity that we will can expect to see. This program is part of my continuing effort to bring quality evidence based health and longevity information to the general public to help inform these choices.  We hope that you enjoy the program. Please join our family and hit subscribe!https://www.robertlufkinmd.com/Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/X: https://x.com/robertlufkinmdYoutube: https://www.youtube.com/robertLufkinmdSubstack: https://robertlufkinmd.substack.com Instagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinThreads: https://www.threads.net/@robertlufkinmdFacebook: ...