Lucia Aronica PhD: Can Diet Reset Epigenetic DNA Methylation Clocks?

#005-Today we learn how diet, genetics, and epigenetics interact with each other to impact our health and longevity, and how to use this information to design personalized lifestyle interventions from a true expert in the field.

Dr. Lucia Aronica received her PhD from the University of Vienna and has research experience from the University of Oxford, University of Southern California, and University Federico II of Naples. She is also Lecturer at the Stanford Prevention and Research Center, Genomics Lead at Metagenics Inc., and editor of the peer-reviewed journal Life by MDPI. 

Take away points: 
-We get our genetic information from our ancestors while epigenetic information is from our life experiences
-Epigenetic change can occur via three mechanisms: 1- small RNA, 2-histone modification, and 3-DNA Methylation
-DNA Methylation is currently the best epigenetic modification for detailed epigenetic analysis
-First generation DNA methylation clocks (Horvath et al) were chronological clocks, while second generation clocks (GrimAge, etc) tend to be biological clocks trained on specific conditions/phenotype
-Chronological clocks are useful in forensic applications
-Chronological age can deviate from biological age reflecting varying risk for outcomes
-Athletes showing increased biological age may be related to short term inflammatory genes and cytokines for the adaptive stress response to exercise
-In Ketogenic diets can see down regulation of excitatory brain pathways as possible mechanism for effects in epilepsy population
-Induced pleuripotent stem cells can be produced by transcription factors that reverse epigenetic age
-Biologic DNA methylation clocks are very valuable for lifestyle intervention and longevity research

laronica@stanford.edu 

https://draronica.com/

https://www.youtube.com/user/81luxar

https://continuingstudies.stanford.edu/courses/liberal-arts-and-sciences/longing-for-longevity-from-biology-to-biohacking/20211_BIO-07 

Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, Kraemer HC, King AC. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2007 Mar 7;297(9):969-77. doi: 10.1001/jama.297.9.969. Erratum in: JAMA. 2007 Jul 11;298(2):178. PMID: 17341

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