Neil deGrasse Tyson and Chuck Nice delve into topics like particle entanglement, the behavior of physics on different scales, objects and dimensions, black holes, the flow of time, and answer Patreon member questions.

Neil deGrasse Tyson and co-hosts discuss the physics of 'The Tush Push' and the science in American football. They explore the unstoppable phenomena in the universe and the effectiveness of jumping in football. They also delve into strategies and physics in rugby and American football, and the invention of new moves in sports.

Mycologist Bryn Dentinger joins Neil deGrasse Tyson and Chuck Nice to explore the weird world of mushrooms, including their effects on humans, potential benefits in treating depression and PTSD, cultivation challenges, and the parallels between plant life and the universe.

Physician and global health expert, Peter Hotez, joins Neil deGrasse Tyson and comedian Paul Mecurio to discuss disease prevention, vaccine skepticism, the influence of Fox News on the anti-vaccine movement, challenges of discussing vaccines with skeptical family members, tribal forces at play in society, and the importance of public engagement in combating anti-science movements.

Astrophysicist Charles Liu answers cosmic queries about Hawking Radiation, the speed of light, and the rarity of black holes. They explore time as a multidimensional dimension and discuss the formation of black holes and their ratio to regular stars. The speakers also discuss measuring gravitational constants, a famous Olympic story, clocks in particles, and the use of AI and machine learning in astronomy.

Gaurav Shah, CEO of Rocket Pharma, talks about the science of gene therapy and how it can treat and potentially cure rare diseases. They discuss the use of modified viruses, the significance of rare diseases, advancements in gene therapy, ethical implications, and the importance of people and investors in the field.

Neil deGrasse Tyson and Chuck Nice explore the future of commercial spaceflight with engineer and executive Lauren Lyons. Topics include contamination control and safety measures, the use of cameras and data, consequences of failure in the industry, exciting technologies, fully reusable rockets and refueling stations in space, and opportunities and predictions in commercial spaceflight.

Will Harris, herdsman and author, discusses the future of food production, regenerative agriculture, and greenwashing. Topics include regenerative farming's impact on climate and health, the difference between grass-fed and grain-fed cattle, the negative effects of industrialized farming on rural America, and the benefits of regenerative farming practices. The speakers also discuss the role of nature in farming, avoiding toxins, and building a sustainable future.

George Mashour, anesthesiologist and founder of the Michigan Psychedelic Center, joins Neil deGrasse Tyson and Chuck Nice to discuss the study of consciousness and the potential of psychedelics. They explore altered states, emergence of consciousness in infants, theories of consciousness, replicating the human brain, and the impact of psychedelics on consciousness and mental health treatment.

Neil deGrasse Tyson and Chuck Nice discuss wormholes, their potential applications in transportation, and the unique characteristics of wormholes. They explore the relationship between religious experiences and science, questioning the concept of miracles. The hosts delve into the idea of achieving absolute nothingness, the role of AI in scientific discoveries, and the importance of nurturing curiosity in young scientists.